Benítez HA, Garcés YR, Hernández P

Language: Spanish
References: 0
Page: 143-152
PDF size: 198.30 Kb.

ABSTRACT

Introduction: Spinal cord injury is a devastating condition caused by spinal cord injury with high morbidity and mortality, and for which there is no effective treatment available through conventional treatments. At present, some neurorregenerative strategies have been proposed, among them the implantation of stem cells. This procedure has created new expectations in the search for an effective treatment for this type of injury.
Objective: To evaluate the feasibility and safety of implantation in the injured spinal cord of autologous stem cells derived from the bone marrow.
Methods: Autologous stem cells from the bone marrow were implanted at open-air into the site of the lesion, combined or not with systemically administration of the neurostimulant cytokines (granulocyte colony-stimulating factor and recombinant erythropoietin).
Results: Twenty-five adult patients with chronic complete spinal cord injury were included. The most frequent mechanism of production was the traffic accident. After treatment, many significant evolutionary changes in the sensory and motor evolution, were observed in the patients treated with stem cells combined with the neurostimulant cytokines.
Conclusions: The feasibility and safety of the cellular implant and its association with neurostimulant cytokines were demonstrated, since there were no major complications.