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2006, Number 1

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Rev Mex Patol Clin Med Lab 2006; 53 (1)

Cytomegalovirus and renal transplant: A dangerous combination

Barba EJR

Language: Spanish
References: 33
Page: 52-61
PDF size: 88.04 Kb.


ABSTRACT

Cytomegalovirus (CMV) belongs to the Herpesviridae family with ubiquity, host latency, and cytotoxic effect as its major characteristics. Cytomegalovirus is the most common infection among immunosuppressed patients, commonly presenting as a wide range of clinical manifestations. Among transplant recipients, the infection is usually diagnosed in the first 4 months after starting immunosuppression; it is associated with high morbidity and mortality rates. Depending on the serologic status of the donor/recipient pair at the time of the transplantation and the type of immunosuppression, 60 to 100% of the renal transplant recipients develop active cytomegalovirus infection, in 35% causes symptomatic disease (fever, leucopenia, epigastric pain, arthralgia, hepatitis, diarrhea, oral ulcers, encephalitis, pneumonitis, thrombocytopenia, atypical lymphocytosis and deranged liver function) and death in 2%.


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