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Revista Médica Sinergia

2019, Number 01

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Revista Médica Sinergia 2019; 4 (01)

Microbiota and vaginal dysbiosis

Mora ASÁ

Language: Spanish
References: 35
Page: 3-13
PDF size: 270.42 Kb.


ABSTRACT

The human body is colonized by a large number of microbes which are collectively called human microbiota. The relationship between them and human health has been a great study in recent years.
At the vaginal level, the presence of these microorganisms has been correlated with the maintenance of a dynamic vaginal ecosystem and proper to prevent colonization and infection by opportunistic pathogens.
The stable vaginal pH of women in the reproductive stage is maintained thanks to estrogen, glycogen and lactobacilli, due to its lactic acid product.
Said lactobacilli favor the immune response and combat the colonization of the periureteral epithelium by uropathogens.
This vaginal ecosystem can be altered by various intrinsic mechanisms of the host or by external factors such as the intake of antibiotics, intravaginal practices, food or snuff.
The importance of maintaining a stable vaginal ecosystem lies in avoiding vaginal infections and their possible complications.


REFERENCES

  1. Wang B, Yao M, Lv L, Ling Z, Li L. The Human Microbiota in Health and Disease. Engineering. 2017 02;3(1):71-82. https://doi.org/10.1016/j.eng.2017.01.008

  2. Stoyancheva G, Marzotto M, Dellaglio F, Torriani S. Bacteriocin production and gene sequencing analysis from vaginal Lactobacillus strains. Archives of Microbiology. 2014 06 12;196(9):645-653. https://doi.org/10.1007/s00203-014-1003-1

  3. Amabebe E, Anumba DOC. The Vaginal Microenvironment: The Physiologic Role of Lactobacilli. Frontiers in Medicine. 2018 06 13;5. https://doi.org/10.3389/fmed.2018.00181

  4. Gartner L, Hiatt J. Texto Atlas de Histología. 3 ed.. McGraw-Hill; 2008.

  5. Mossop H, Linhares IM, Bongiovanni AM, Ledger WJ, Witkin SS. Influence of Lactic Acid on Endogenous and Viral RNA-Induced Immune Mediator Production by Vaginal Epithelial Cells. Obstetrics & Gynecology. 2011 Oct;118(4):840-846. https://doi.org/10.1097/aog.0b013e31822da9e9

  6. Martín R, Soberón N, Vázquez F, Suárez JE. La microbiota vaginal: composición, papel protector, patología asociada y perspectivas terapéuticas. Enfermedades Infecciosas y Microbiología Clínica. 2008 03;26(3):160-167. https://doi.org/10.1157/13116753

  7. Lewis FMT, Bernstein KT, Aral SO. Vaginal Microbiome and Its Relationship to Behavior, Sexual Health, and Sexually Transmitted Diseases. Obstetrics & Gynecology. 2017 04;129(4):643-654. https://doi.org/10.1097/aog.0000000000001932

  8. Witkin SS, Mendes-Soares H, Linhares IM, Jayaram A, Ledger WJ, Forney LJ. Influence of Vaginal Bacteria and D- and L-Lactic Acid Isomers on Vaginal Extracellular Matrix Metalloproteinase Inducer: Implications for Protection against Upper Genital Tract Infections. mBio. 2013 08 06;4(4). https://doi.org/10.1128/mbio.00460-13

  9. Smith SB, Ravel J. The vaginal microbiota, host defence and reproductive physiology. The Journal of Physiology. 2016 05 05;595(2):451-463. https://doi.org/10.1113/jp271694

  10. Nagy E, FROMan G, MARDH P. Fibronectin binding of Lactobacillus species isolated from women with and without bacterial vaginosis. Journal of Medical Microbiology. 1992 07 01;37(1):38-42. https://doi.org/10.1099/00222615-37-1-38

  11. Boris S, Suárez JE, Vázquez F, Barbés C. Adherence of Human Vaginal Lactobacilli to Vaginal Epithelial Cells and Interaction with Uropathogens. Infection and Immunity. 1998;66(5):1985- 1989.

  12. Mas M. Fisiología de la respuesta sexual femenina: actualización. Revista Internacional de Andrología. 2007 01;5(1):11-21. https://doi.org/10.1016/s1698-031x(07)74029-3

  13. Boskey E, Cone R, Whaley K, Moench T. Origins of vaginal acidity: high d/l lactate ratio is consistent with bacteria being the primary source. Human Reproduction. 2001 09;16(9):1809- 1813. https://doi.org/10.1093/humrep/16.9.1809

  14. T j G O’H DE R J T y x antimicrobial factor produced by vaginal microbiota. Microbiome. 2018 02 06;6(1). https://doi.org/10.1186/s40168-018-0418-3

  15. Strus M, Brzychczy-WÅ M, Gosiewski T, Kochan P, Heczko PB. The in vitro effect of hydrogen peroxide on vaginal microbial communities. FEMS Immunology & Medical Microbiology. 2006 Oct;48(1):56-63. https://doi.org/10.1111/j.1574-695x.2006.00120.x

  16. Borgogna JC, Yeoman CJ. The Application of Molecular Methods Towards an Understanding of the Role of the Vagina Microbiome in Health Disease. Methods in Microbiology. 2017 Jan;44:37-65. https://doi.org/10.1016/bs.mim.2017.08.003

  17. Bradley F, Birse K, Hasselrot K, Noël-Romas L, Introini A, Wefer H, Seifert M, Engstrand L, Tjernlund A, Broliden K, Burgener AD. The vaginal microbiome amplifies sex hormoneassociated cyclic changes in cervicovaginal inflammation and epithelial barrier disruption. American Journal of Reproductive Immunology. 2018 04 30;80(1):e12863. https://doi.org/10.1111/aji.12863

  18. Muhleisen AL, Herbst-Kralovetz MM. Menopause and the vaginal microbiome. Maturitas. 2016 09;91:42-50. https://doi.org/10.1016/j.maturitas.2016.05.015

  19. Brotman R, Gajer P, Holm J, Robinson C, Ma B, Humphrys M, Tuddenham S, Ravel J, Ghanem K. Hormonal contraception is associated with stability and lactobacillus-dominance of the vaginal microbiota in a two-year observational study. American Journal of Obstetrics and Gynecology. 2016 Dec;215(6):S828-S829. https://doi.org/10.1016/j.ajog.2016.09.031

  20. Fashemi B, Delaney ML, Onderdonk AB, Fichorova RN. Effects of feminine hygiene products on the vaginal mucosal biome. Microbial Ecology in Health & Disease. 2013 02 25;24(0). https://doi.org/10.3402/mehd.v24i0.19703

  21. Amabebe E, Anumba DOC. Psychosocial Stress, Cortisol Levels, and Maintenance of Vaginal Health. Frontiers in Endocrinology. 2018 09 24;9. https://doi.org/10.3389/fendo.2018.00568

  22. Hickey R, Abdo Z, Zhou X, Nemeth K, Hansmann M, Osborn T, Wang F, Forney L. Effects of tampons and menses on the composition and diversity of vaginal microbial communities over time. BJOG: An International Journal of Obstetrics & Gynaecology. 2013 02 11;120(6):695-706. https://doi.org/10.1111/1471-0528.12151

  23. Miller EA, Beasley DE, Dunn RR, Archie EA. Lactobacilli Dominance and Vaginal pH: Why Is the Human Vaginal Microbiome Unique?. Frontiers in Microbiology. 2016 Dec 08;7. https://doi.org/10.3389/fmicb.2016.01936

  24. Brotman RM, He X, Gajer P, Fadrosh D, Sharma E, Mongodin EF, Ravel J, Glover ED, Rath JM. Association between cigarette smoking and the vaginal microbiota: a pilot study. BMC Infectious Diseases. 2014 08 28;14(1). https://doi.org/10.1186/1471-2334-14-471

  25. Romero R, Dey SK, Fisher SJ. Preterm labor: One syndrome, many causes. Science. 2014 08 14;345(6198):760-765. https://doi.org/10.1126/science.1251816

  26. Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: a systematic review. American Journal of Obstetrics and Gynecology. 2013 Dec;209(6):505-523. https://doi.org/10.1016/j.ajog.2013.05.006

  27. Neggers YH, Nansel TR, Andrews WW, Schwebke JR, Yu K, Goldenberg RL, Klebanoff MA. Dietary Intake of Selected Nutrients Affects Bacterial Vaginosis in Women. The Journal of Nutrition. 2007 09 01;137(9):2128-2133. https://doi.org/10.1093/jn/137.9.2128

  28. Simon C. Introduction: Do microbes in the female reproductive function matter?. Fertility and Sterility. 2018 08;110(3):325-326. https://doi.org/10.1016/j.fertnstert.2018.06.041

  29. Amabebe E, Anumba DOC. Psychosocial Stress, Cortisol Levels, and Maintenance of Vaginal Health. Frontiers in Endocrinology. 2018 09 24;9. https://doi.org/10.3389/fendo.2018.00568

  30. Hickey R, Abdo Z, Zhou X, Nemeth K, Hansmann M, Osborn T, Wang F, Forney L. Effects of tampons and menses on the composition and diversity of vaginal microbial communities over time. BJOG: An International Journal of Obstetrics & Gynaecology. 2013 02 11;120(6):695-706. https://doi.org/10.1111/1471-0528.12151

  31. Brotman RM, He X, Gajer P, Fadrosh D, Sharma E, Mongodin EF, Ravel J, Glover ED, Rath JM. Association between cigarette smoking and the vaginal microbiota: a pilot study. BMC Infectious Diseases. 2014 08 28;14(1). https://doi.org/10.1186/1471-2334-14-471

  32. Neggers YH, Nansel TR, Andrews WW, Schwebke JR, Yu K, Goldenberg RL, Klebanoff MA. Dietary Intake of Selected Nutrients Affects Bacterial Vaginosis in Women. The Journal of Nutrition. 2007 09 01;137(9):2128-2133. https://doi.org/10.1093/jn/137.9.2128

  33. Miller EA, Beasley DE, Dunn RR, Archie EA. Lactobacilli Dominance and Vaginal pH: Why Is the Human Vaginal Microbiome Unique?. Frontiers in Microbiology. 2016 Dec 08;7. https://doi.org/10.3389/fmicb.2016.01936

  34. Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: a systematic review. American Journal of Obstetrics and Gynecology. 2013 Dec;209(6):505-523. https://doi.org/10.1016/j.ajog.2013.05.006

  35. Romero R, Dey SK, Fisher SJ. Preterm labor: One syndrome, many causes. Science. 2014 08 14;345(6198):760-765. https://doi.org/10.1126/science.1251816




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