Ballesteros HM, Guirado BO, Rodríguez PA

Language: Spanish
References: 0
Page: 3-11
PDF size: 326.39 Kb.

ABSTRACT

Introduction: high blood pressure is a multifactorial disease; its manifestation depends on genetic, epigenetic and environmental factors that influence each individual.
Objective: to be updated with the most relevant aspects on the role of genes and the environment in the development of arterial hypertension.
Methods: a search in publications database such as Pubmed, EBSCO, Google Scholar and SciELO was carried out; selected articles from prestigious journals were selected, 90% of them correspond to the last 5 years.
Conclusions: arterial hypertension is a disease characterized by pathophysiological mechanisms and with hundreds of genes involved in which underlie a series of alterations that differentiate and define them in different groups. To differentiate individuals who only have in common the criterion of having blood pressure readings higher than 140/90 mmHg, was very difficult. The development of researches related to the knowledge of genes involved, their polymorphisms or their epigenetic modifications, and especially, their phenotypic expression, with the identification of the predominant physiopathological mechanism in the elevation of blood pressure, contribute to a more individualized treatment of the disease with a better pharmacological and non-pharmacological approach.