Álvarez RM, Álvarez AAM, Barrantes JM

Language: Spanish
References: 52
Page: 1-22
PDF size: 663.20 Kb.

ABSTRACT

This study was carried out for 13 years in six patients with muscular dystrophy. Two of them associated with neuropathy and four with healthy nerves. The objective of the research is to demonstrate that the use of Neostigmine in the treatment of progressive muscular dystrophy, as competitor, reactivator and facilitator of the glycosylation of alpha distroglycan receptors. The six patients started taking from 3 to 5 tablets of Neostigmine a day. With this treatment an increase in muscle strength was shown in one month. Four of the patients experienced an increase in muscular strength which remained for 13 years in which they had a better quality of life and equal opportunities as a healthy individual. The physiopathology of progressive muscular dystrophy is the genetic block to the glycosylation of alpha dystroglycan receptors that produces muscle weakness. Neostigmine is used as an acetylcholinesterase inhibitor in the treatment of Myasthenia Gravis (indirect action). The direct action is competitor and unblocker of the receiver, this facilitates glycolization, increasing muscle strength.

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