medigraphic.com
Órgano Oficial del Hospital Angeles Health System

2018, Number 4

<< Back Next >>

Acta Med 2018; 16 (4)

Chemical pneumonitis secondary to accidental inhalation of heptane

Navarro RFP, Carrillo RSC, Ochoa SH, Ortega CMJ

Language: Spanish
References: 15
Page: 353-356
PDF size: 168.05 Kb.


ABSTRACT

Smoke, warmth or chemicals, when inhalated, may cause injury to the respiratory tract. An hypersensibility reaction is caused by antigens on the lung parenchyma. The symptomatology presents itself hours or even days after the antigen exposure and the radiologic manifestations include acute pulmonary edema, interstitial fibrosis, diffused bilateral ground-glass, opacities, especially in subacute forms. The mainstay in treatment is the avoidance of the causative antigen, supportive therapies, costioesteroid therapy and bronchodilators. The prognosis is good: 90% of the patients are able to fully recover, the other 10%, presents acute respiratory failure, larynx injury or acute pulmonary edema. We present the case of a man, 39 years old, with accidental exposure to a product made of heptane; this man was admitted to Intensive Care Unit and was treated with corticosteroids, invasive mechanical ventilation, for 96 hours, with appropriate response to the treatment.


REFERENCES

  1. Woodson CL. Diagnosis and treatment of inhalation injury. In: Herndon DN (ed). Total burn care. 4 ed, 2009.

  2. Beauchamp RO, Bus JS, Popp JA. A critical review of the literature on hydrogen sulfide toxicity. CRC Crit Rev Toxicol.1984; 13: 25-97.

  3. Miller K, Chang A. Acute inhalation injury. Emerg Med Clin North Am. 2003; 21: 533-557.

  4. Agency for toxic substances and disease registry. Available at: http://www.atsdr.cdc.gov/.

  5. Toxicity Hydrocarbons. Available at: www.emedicine.com/emerg/topic873.htm#.

  6. Burns MJ, Dickson EW, Sivilotti ML, Hocker M, Porcaro WA. Enhanced mortality from perfl uorocarbon administration in a rat model of kerosene aspiration. J Toxicol Clin Toxicol. 1999; 37: 855-859.

  7. Widner LR, Goodwin SR, Berman LS, Banner MJ, Freid EB, McKee TW. Artificial surfactant for therapy in hydrocarbon-induced lung injury in sheep. Crit Care Med. 1996; 24: 1524-1529.

  8. Kurtzman TL, Otsuka KN, Wahl RA. Inhalant abuse by adolescents. J Adolesc Health. 2001; 28: 170-180.

  9. Williams JF, Storck M. Inhalant abuse. Pediatrics. 2007; 119: 1009-1017.

  10. Bowen SE, Batis JC, Paez-Martinez N, Cruz SL. The last decade of solvent research in animal models of abuse: mechanistic and behavioral studies. Neurotoxicol Teratol. 2006; 28: 636-647.

  11. Howard MO, Bowen SE, Garland EL, Perron BE, Vaughn MG. Inhalant use and inhalant use disorders in the United States. Addict Sci Clin Pract. 2011; 6: 18-31.

  12. Shusterman D. Upper and lower airway sequelae of irritant inhalations. Clin Pulm Med. 1999; 6: 18-31.

  13. MacIver MB. Abused inhalants enhance GABA-mediated synaptic inhibition. Neuropsychopharmacol. 2009; 34: 2296-2304.

  14. Gorguner M, Aslan S, Inandi T, Cakir Z. Reactive airways dysfunction syndrome in housewives due to a bleach-hydrochloric acid mixture. Inhal Toxicol. 2004; 16: 87-91.

  15. Myers JL, Colby TV. Pathological manifestation of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diff use panbronchiolitis. Clin Chest Med. 1993; 14: 611-622.




2020     |     www.medigraphic.com