medigraphic.com

2018, Number 2

<< Back Next >>

Rev Educ Bioquimica 2018; 37 (2)

Funciones no-canónicas de los canales de potasio activados por voltaje

Delgado RM, Rodríguez MAA

Language: Spanish
References: 32
Page: 41-47
PDF size: 678.78 Kb.


ABSTRACT

Voltage gated potassium (Kv) channels are proteins that form potassium (K+) selective pores in cell membranes. They open or close in response to changes in the transmembrane potential and are essential for repolarizing action potentials, and thus for the functioning of excitable tissue. In addition to these well-known functions, it has recently been proposed that some Kv channels can influence cellular events in ways that do not depend on their function as ion channels. This review present examples of the non-canonical functions of Kv channels.


REFERENCES

  1. González C, Baez-Nieto D, Valencia I, Oyarzún I, Rojas P, Naranjo D, Latorre R (2012) K(+) channels: function-structural overview. Compr Physiol 2:2087-2149.

  2. Pongs O, Leicher T, Berger M, Roeper J, Bähring R, Wray D, Giese KP, Silva AJ, Storm JF (1999) Functional and molecular aspects of voltage-gated K+ channel beta subunits. Ann N Y Acad Sci 868:344-355.

  3. Hille B (2001) Ion Channels of Excitable Membranes, 3rd ed. Editor: Sinauer, Sunderland, Mass.

  4. Feinshreiber L, Chikvashvili D, Michaelevski I, Lotan I (2009) Syntaxin modulates Kv1.1 through dual action on channel surface expression and conductance. Biochemistry 48:4109-4114.

  5. Szabò I, Zoratti M, Gulbins E (2010) Contribution of voltage-gated potassium channels to the regulation of apoptosis. FEBS Lett 584:2049-2056.

  6. Huang X, Jan LY (2014) Targeting potassium channels in cancer. J Cell Biol 206:151-162.

  7. Kaczmarek LK (2006) Non-conducting functions of voltage-gated ion channels. Nat Rev Neurosci 7:761-771.

  8. Urrego D, Tomczak AP, Zahed F, Stühmer W, Pardo LA (2014) Potassium channels in cell cycle and cell proliferation. Philos Trans R Soc Lond B Biol Sci 369:20130094.

  9. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD (1984) Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature 307:465-468.

  10. Pardo LA, Sühmer W (2008) Eag1 as a cancer target. Expert Opin Ther Targets 12:837-843.

  11. Haitin Y, Carlson AE, Zagotta WN (2013) The structural mechanism of KCNH-channel regulation by the eag domain. Nature 501:444-448.

  12. Hegle AP, Marble DD, Wilson GF (2006) A voltage-driven switch for ion-independent signaling by ether-à-go-go K+ channels. Proc Natl Acad Sci U S A 103:2886-2891.

  13. Cidad P, Jiménez-Pérez L, García-Arribas D, Miguel-Velado E, Tajada S, Ruiz-McDavitt C, López-López JR, Pérez-García MT (2012) Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism. Arterioscler Thromb Vasc Biol 32:1299-1307.

  14. Glassmeier G, Hempel K, Wulfsen I, Bauer CK, Schumacher U, Schwarz JR (2012) Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells. Pflugers Arch 463:365-376.

  15. Lee JH, Park JW, Byun JK, Kim HK, Ryu PD, Lee SY, Kim DY (2015) Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells. Oncotarget 6:8132-8143.

  16. Jahn R (2004) Principles of exocytosis and membrane fusion. Ann N Y Acad Sci 1014:170- 178.

  17. Feinshreiber L, Singer-Lahat D, Ashery U, Lotan I (2009) Voltage-gated potassium channel as a facilitator of exocytosis. Ann N Y Acad Sci 1152:87-92.

  18. Leung YM, Kang Y, Gao X, Xia F, Xie H, Sheu L, Tsuk S, Lotan I, Tsushima RG, Gaisano HY (2003) Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking. J Biol Chem 278:17532- 17538.

  19. Leung YM, Kang Y, Xia F, Sheu L, Gao X, Xie H, Tsushima RG, Gaisano HY (2005) Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels. Biochem J 387:195-202.

  20. Singer-Lahat D, Sheinin A, Chikvashvili D, Tsuk S, Greitzer D, Friedrich R, Feinshreiber L, Ashery U, Benveniste M, Levitan ES, Lotan I (2007) K+ cannel facilitation of exocytosis by dynamic interaction with syntaxin. J Neurosci 27:1651-1658.

  21. Singer-Lahat D, Chikvashvili D, Lotan I (2008) Direct interaction of endogenous Kv channels with syntaxin enhances exocytosis by neuroendocrine cells. PLoS One 3:e1381.

  22. Feinshreiber L, Singer-Lahat D, Friedrich R, Matti U, Sheinin A, Yizhar O,Nachman R, Chikvashvili D, Rettig J, Ashery U, Lotan I (2010) Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells. J Cell Sci 123:1940-1947.

  23. Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE (2012) The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function. Diabetologia 55:1709-1720.

  24. Deutsch E, Weigel AV, Akin EJ, Fox P, Hansen G, Haberkorn CJ, Loftus R, Krapf D, Tamkun MM (2012) Kv2.1 cell surface clusters are insertion platforms for ion cannel delivery to the plasma membrane. Mol Biol Cell 23:2917- 2929.

  25. Fox PD, Haberkorn CJ, Weigel AV, Higgins JL, Akin EJ, Kennedy MJ, Krapf D, Tamkun MM (2013) Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubs. Mol Biol Cell 24:2703-2713.

  26. Fox PD, Haberkorn CJ, Akin EJ, Seel PJ, Krapf D, Tamkun MM (2015) Induction of stable ER-plasma-membrane junctions by Kv2.1 potassium channels. J Cell Sci 128:2096- 2105.

  27. O’Connell KM, Tamkun MM (2005) Targeting of voltage-gated potassium channel isoforms to distinct cell surface microdomains. J Cell Sci 118:2155-2166.

  28. Sarmiere PD, Weigle CM, Tamkun MM (2008) The Kv2.1 K+ channel targets to the axon initial segment of hippocampal and cortical neurons in culture and in situ. BMC Neurosci 9:112.

  29. O’Connell KM, Loftus R, Tamkun MM (2010) Localization-dependent activity of the Kv2.1 delayed-rectifier K+ channel. Proc Natl Acad Sci U S A 107:12351-12356.

  30. Dominguez R (2009) Actin filament nucleation and elongation factors--structure-function relationships. Crit Rev Biochem Mol Biol 44:351-366.

  31. Bezanilla M, Gladfelter AS, Kovar DR, Lee WL (2015) Cytoskeletal dynamics: a view from the membrane. J Cell Biol 209:329-337.

  32. Zhang Y, Zhang XF, Fleming MR, Amiri A, El- Hassar L, Surguchev AA, Hyland C,Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL,Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK (2016) Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell 165:434-448.




2020     |     www.medigraphic.com