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2018, Number 3

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Dermatología Cosmética, Médica y Quirúrgica 2018; 16 (3)

Immunology of Alopecia Areata. Lost of the Immune Orivilege (Part I)

Sánchez ÁI, González HWC, Ponce ORM

Language: Spanish
References: 64
Page: 229-236
PDF size: 264.50 Kb.


ABSTRACT

The hair follicle is considered an immunological model not completely elucidated. From the clinical models to the now a days molecular advances, we continue without completely understanding the immunological machinery. The anatomical characteristics, the low to null expression on MHC-II and the microenvironment provided by hormones, neuropeptides and immunomodulatory cytokines enhance this immunological privileged environment. This lost goes further than the balance between innate and acquired immunity. The auto reactivity against own and unknown antigens, the induction against melanic antigens, the inhibition of immune control and the intestinal microbiome status are novel key pieces of this puzzle.


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