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2018, Number 3

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Gac Med Mex 2018; 154 (3)

Factors associated with five-year survival in children with cerebral astrocytoma

Sevilla-Castillo RA, Andrade-Sarmiento LA

Language: Spanish
References: 18
Page: 283-286
PDF size: 145.89 Kb.


ABSTRACT

Introduction: The second cause of children’s death is cancer, with leukemia and central nervous system tumors being the most common, among which astrocytomas account for 40%. Objective: To find out the factors associated with 5-year survival in children with cerebral astrocytoma. Method: Case-control study nested in a retrospective cohort of patients diagnosed with cerebral astrocytoma who received treatment from December 2006 to January 2010. Descriptive statistics and the chi-square test were carried out; the Kaplan-Meier method was used to assess survival. Results: Twenty-one patients diagnosed with cerebral astrocytoma were included; survival was 76% at 5 years; with pilocytic astrocytoma being the most common (61%); mean age was 7 years, and male gender was predominant; age at death ranged from 8 to 12 years (p = 0.022), with 80% of deceased patients having infratentorial localization (OR = 17.3; 95% CI = 1-622; p = 0.01). There was no treatment-attributable survival difference. Conclusions: Five-year survival was 76%; the limiting risk factor is tumor infratentorial localization.


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