medigraphic.com
Organo Oficial de la Sociedad Mexicana de Urología

2018, Number 3

<< Back Next >>

Rev Mex Urol 2018; 78 (3)

Clinical presentation and oncologic results of kidney cancer at a hospital in Northern Mexico

Uscanga-Yépez J, Martínez-González A, Segovia-Sandoval K, Barrera-Juárez E, Gonzalez-Oyervides R

Language: Spanish
References: 23
Page: 176-182
PDF size: 291.39 Kb.


ABSTRACT

Objective: To report our experience with the surgical treatment and histopathologic characteristics of patients with renal cell carcinoma at a hospital in Northern Mexico.
Materials and Methods: A descriptive, cross-sectional study was conducted through the review of the case records of patients operated on for kidney tumor. Radical or partial nephrectomy was decided upon, according to the nephrometry score from contrastenhanced abdominal tomography and the criterion of the surgeon. The comorbidities evaluated were: high blood pressure, type 2 diabetes mellitus, gross hematuria, flank pain, and increased volume in the hypochondrium. Glomerular filtration rate was registered before surgery and 15 days after the procedure and was calculated using the Modification of Diet in Renal Disease (MDRD) formula. Variables were analyzed using measures of central tendency and survival was assessed through the Kaplan- Meier curves.
Results: Eighty-nine cases were registered. Symptoms presented in 74% the most common of which were hematuria and flank pain. Radical nephrectomy predominated, and the mean pathologic tumor size was 6.7 cm. A total of 84% of the cases had stage T1b to T4 disease. Estimated 5-year cancer-specific survival for all stages was 90% and recurrence-free survival for organ-confined stages was 83.1%. The type of surgery had no statistical influence on postoperative kidney function (p = 0.33).
Conclusion: The histopathologic characteristics, treatment, and survival in patients with kidney cancer were similar to those reported in other countries.


REFERENCES

  1. Ljungberg B, Bensalah K, Canfield S, Dabestani S, et al. EAU Guidelines on Renal Cell Carcinoma: 2014 Update. Eur J. 2015;67:913-924.

  2. Patard JJ. Incidental renal tumouinrs. Curr Opin Urol. 2009;19(5):454-458. doi:10.1097/MOU.0b013e32832f0ccd.

  3. Adibi M, Karam JA, Wood CG. Reporting geographic and temporal trends in renal cell carcinoma: Why is this important? Eur Urol. 2015;67(3):531-532. doi:10.1016/j. eururo.2014.10.030.

  4. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin 2017;67(1):7-30. doi:10.3322/caac.21387.

  5. Thompson RH, Hill J, Babayev Y, Cronin A, et al. Risk of metastatic renal cell carcinoma according to tumor size. J Urol 2010;182(1):41-45. doi:10.1016/j.juro.2009.02.128.RISK.

  6. Lorente D, Trilla E, Meseguer A, Planas J, et al. Revisión sistemática de los factores pronósticos del carcinoma renal. Actas Urol Esp 2017;41(4)215-25.

  7. Eggener SE, Yossepowitch O, Pettus JA, et al. Renal cell carcinoma recurrence after nephrectomy for localized disease: predicting survival from time of recurrence. J Clin Oncol 2006;24:3101-3106.

  8. Luciani LG, Cestari R, Tallarigo C. Incidental renal cell carcinoma-age and stage characterization and clinical implications: study of 1092 patients (1982-1997). Urology. 2000;56(1):58-65.

  9. DeCastro GJ, McKiernan JM. Epidemiology, clinical staging, and presentation of renal cell carcinoma. Urol Clin North Am 2008;35(4):581-592. doi:10.1016/j.ucl.2008.07.005.

  10. National Cancer Institute. Cancer Stat Fact: Kidney and Renal Pelvis Cancer. [en línea]. Dirección URL .

  11. Levey AS, Coresh J, Greene T, Stevens LA, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006;145(4):247-254. doi:10.7326/0003-4819-145-4-200608150-00004.

  12. Suarez-Sarmiento A, Yao X, Hofmann JN, Syed JS, et al. Ethnic disparities in renal cell carcinoma: An analysis of Hispanic patients in a single-payer healthcare system. Int J Urol 2017;24(10):765-770. doi:10.1111/iju.13424.

  13. Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol 2010;7:245.

  14. Colt JS, Schwartz K, Graubard BI, Davis F, R, et al. Hypertension and risk of renal cell carcinoma among white and black Americans. Epidemiol 2011;22:797.

  15. Purdue MP, Moore LE, Merino MJ, Boffetta P, et al. An investigation of risk factors for renal cell carcinoma by histologic subtype in two case-control studies. Int J Cancer 2013;132:2640.

  16. Hollingsworth JM, Miller DC, Daignault S, Hollenbeck BK. Rising incidence of small renal masses: A need to reassess treatment effect. J Natl Cancer Inst. 2006;98(18):1331- 1334. doi:10.1093/jnci/djj362.

  17. Sand KE, Hjelle KM, Rogde ÅJ, Gudbrandsđottir G, Bostad L, Beisland C. Incidentally detected renal cell carcinomas are highly associated with comorbidity and mortality unrelated to renal cell carcinoma. Scand J Urol 2013;47(6):462-471. doi:10.3109/21681805.2013.777364.

  18. Smaldone MC, Corcoran AT, Uzzo RG. Active surveillance of small renal masses. Nat Rev Urol 2013;10(5):266-274. doi:10.1038/nrurol.2013.62.

  19. Abouassaly R, Lane BR, Novick AC. Active surveillance of renal masses in elderly patients. J Urol 2008;180:505-509. doi:10.1016/j.juro.2008.04.033.

  20. Levinson AW, Su LM, Agarwal D, Sroka M, et al. Long-term oncological and overall outcomes of percutaneous radio frequency ablation in high risk surgical patients with a solitary small renal mass. J Urol. 2008;180(2):499-504. doi:10.1016/j.juro.2008.04.031.

  21. MacLennan S, Imamura M, Lapitan MC, Omar MI, et al. Systematic review of oncological outcomes following surgical management of localised renal cancer. Eur Urol 2012;61:972-993. doi:10.1016/j.eururo.2012.02.039.

  22. Zhang C, Li X, Hao H, Yu W, He Z, Zhou L. The correlation between size of renal cell carcinoma and its histopathological characteristics: A single center study of 1867 renal cell carcinoma cases. BJU Int 2012;110(11 B):481-485. doi:10.1111/j.1464-410X.2012.11173.x.

  23. Sun M, Shariat SF, Cheng C, Ficarra V, Murai M, Oudard S, et al. Prognostic factors and predictive models in renal cell carcinoma: A contemporary review. Eur Urol 2011;60(4):644-661. doi:10.1016/j.eururo.2011.06.041.




2020     |     www.medigraphic.com