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ISSN 1561-3046 (Electronic)

2018, Number 1

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Rev Cub Med Mil 2018; 47 (1)

Progression free survival in patients with meningioma which got Nimotuzumab vaccine

Figueredo AH, Rivero TJR, Matos MA, Bode MA

Language: Spanish
References: 17
Page: 23-32
PDF size: 301.75 Kb.


ABSTRACT

Introduction: in recent years the biology of brain meningiomas has begun to be better understood. Active immunotherapy against epidermal growth factor is an emerging concept, in which it is proposed to manipulate the immune response of the individual, to generate specific antibodies against epidermal growth factor, capable of blocking the ligand / receptor binding and therefore signaling through the latter. The epidermal growth factor receptor is overexpressed in this type of tumor.
Objective: to estimate the progression free survival and its relation with some selected socio-demographic and therapeutic variables.
Methods: a descriptive, cross-sectional study was conducted in 25 patients with meningiomas, treated with a humanized monoclonal antibody (mAb h-R3) (Nimotuzumab), in the Provincial Clinical-Surgical Teaching Hospital "Saturnino Lora" of Santiago de Cuba, from December 1, 2013 to November 30, 2015.
Results: the group of patients included in the study (n= 25), was characterized by the predominance of females (60 %), age 50 and over (68 %), white skin (48 %) and Karnofsky scale of 100 points (84 %). The mean progression-free time was 17 ± 8.6 months.
Conclusions: the main characteristics of progression-free survival of meningiomas were identified in patients vaccinated with mAb h-R3 and the progression-free time reached almost of a year and a half.


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