Amor VAM, Fernández ML, Díaz ACA, Ruiz MV, Lavaut SK, Marsán SV, Machín GS, Garrote SH

Language: Spanish
References: 0
Page: 95-101
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ABSTRACT

The acute leukemias are an heterogenous group of malignant hemopathies diseases characterized by excessive proliferation of an inmature cellular clon. Depending of the myeloid or lymphoid origin of such clon, the acute leukemia could be classified in myeloid or lymphoid respectivement. However, there are cases of acute leukemias with mixed phenotype where immunologic markers of more than on elineage are present. In the patient of this report was founded a mixed immunopheno type pattern by flow cytometry and the entity was classified as acute hybrid lymphoid B/mieloid leukemia. Basedon theinicial diagnostic of acute lymphoid leukemia, the molecular study discovered the presence of E2A-PBX1 fusion gen. That molecular anomaly is formed as consequence of a traslocation between the1 and 19 chromosomes. The patient, a child of 20 months, died 12 days afte rthe first clynic symptoms begining. E2A-PBX1 fusion gen is associated to unfavorable outcome, mainly because the severe damage at the central nervous system as in fact it occurred. Until it was possible review, no any similar report was founded about a case of acute hybrid lymphoidB/myeloid leukemia positive to the E2A-PBX1 fusion gen.