Flores-García A, Ruiz-Bernés S, Aguiar-García P, Benítez-Guerrero V, Valle-Solís MO, Molina-Noyola LD, Torres-Bugarín O

Language: Spanish
References: 18
Page: 56-61
PDF size: 253.50 Kb.

ABSTRACT

Cervical cáncer is the fourth most common cáncer in women worldwide, with an estimated of 528,000 new cases and 266, 000 deaths in 2012. The aim of the present study was to evaluate the genomic instability in women with risk factors by means of buccal micronucleus (MN) cytome assay. Material and methods: A case-control study. The frequencies of nuclear abnormalities —including MN, binucleates (BN), nuclear buds (NBUDs), condensed chromatin (CC), karyorrhexis (KR) and karyolysis (KL)— were evaluated in exfoliated buccal mucosa cells collected from 18 Mexican women with cervical cancer risk factors and 10 women without risk factors (control group). The results showed that frequencies of MNi, BN, NL, CC+KR y KL were significantly increased compared with the control group. Conclusion: Application of the buccal MN-cytome assay for the study of genomic instability in women with cervical cancer risk factors showed that both genotoxic and cytotoxic effects can be evaluated in this study group.

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