2018, Number 4
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Rev Mex Neuroci 2018; 19 (4)
Clinical and electroencephalographic study in infants with risk factors for neurological damage
Rodríguez-Valdés RF, Aguilar-Fabré LL, Rivera-Alés L, Galán-García L, Aguilar-Fabré K, Barrera-Sánchez J, Bosch-Bayard JF
Language: Spanish
References: 38
Page: 25-35
PDF size: 370.24 Kb.
ABSTRACT
Introduction: It’s estimated that between 3-5% of living newborns
have neurology risk. The damage that occurs in perinatal period
cause 55-75% of neurology deficit. Timely detection, follow-up and
intervention permits prevent and/or minimize those aftermaths.
Objectives: To characterizer clinic and electroencephalographic of
a group of children with neurology damage risk factors.
Methods: An early clinic-neurophysiologic evaluation of 87
infants in ages from one month to one year (M 67.53, SD 48.67
days, respectively) was carried out because they showed some
neurology damage risk factor. They were undergoing to digital
electroencephalography studies. The statistical analysis of data was
performed with the Mann-Whitney U test, IC 95% in hypothesis test
(p ‹ 0.05).
Results: Birth risk factors had the highest frequency predominantly
perinatal asphyxia and respiratory distress. The concurrence of 3
or more risk factors was discovered in 66.66% (58/87) of them. A
percentage of 59.09 of EEG performed showed moderate disorders.
There was a significant statistical association between clinical course
of children and presence of seizures, as well as between gestational
age, seizures and 3 or more risk factors.
Conclusions: The early clinical-electroencephalographic
evaluation could be used to guide, modify or suggest therapeutic
strategies and follow-up in infants with neurology damage risk
factors.
REFERENCES
Ferriero D. Neonatal brain injury. N Engl J Med. 2005;351 (19):1985–95.
Clark C, Woodward L. Neonatal cerebral abnormalities and later verbal and visuospatial working memory abilities of children born very preterm. Dev Neuropsychol. 2010;35:622– 42.
Taylor HG, Klein N, Minich NM, Hack M. Middle–school–age outcomes in children with very low birth weight. Child Dev. 2000;71 (6):1495–511. 5.
Peterson B, Anderson AW, Ehrenkranz R, Staib LH, Tageldin M, Colson E, et al. Regional brain volumes and their later neurodevelopmental correlate in term and preterm infants. Pediatrics. 2003; 111 (5):939–48.
Fraello D, Maller–Kesselman J, Vohr B, Katz KH, Kesler S, Schneider K, et al. Consequence of preterm birth in early adolescence: the role of language on auditory short–term memory. J Child Neurol. 2011; 26:738–42.
Hahn JS, Tharp BR. Neonatal and Pediatric Electroencephalography. In: Aminoff MJ (ed).Electrodiagnosis in clinical neurology. New York: Churchill Livingstone1992:93-141.
Laureta E, Mizrahi EM, Moshé SL. Seizures and epilepsies in the preterm and term neonate.In: Shomer DL, da Silva FL (eds.) Niedermeyer´s Electroencephalography: Basic principles, clinical applications, and related fields. Lippincott Williams & Wilkins,2011: 465-479.
Mizrahi EM. Atlas of neonatal electroencephalography. In: Mizrahi EM, Hrachovy RA, Kellaway P (eds.) Philadelphia. Lippincott Williams & Wilkins, 2004.
Poo P, Campistol J, Iriondo M, Recién nacido de riesgo neurológico en el año 2000. Recomendaciones para el seguimiento, incorporación de nuevos instrumentos. Rev Neurol. 2000;31: 645-652.
Alcover-Bloch E, Campistol J, Iriondo-Sanz M. Convulsiones neonatales, experiencia en la unidad. Revista de Neurología. 2004; 38 (9):808-812.
Rey H, Aguilar LE. Seguimiento de neonatos de alto riesgo. En: El recién nacido latinoamericano. Rey H (ed.). Cali: ASPROMEDICA 1986. p. 343-371.
Allen MC. An overview of long-term outcome. En: Witter FR, Keith LG (eds.). Textbook of prematurity. Boston: Little, Brown & Co; 1993. p. 371-383.
Martínez E. Recién nacido de alto riesgo. En: Martínez E, Marttell M, Martínez G, Fayad S, Capurro H, (eds.). Perinatología neonatología. Barranquilla: Ediciones UniNorte; 2000. p. 28-36.
Hill A, Volpe JJ. Hipoxic ischemic cerebral in the newborn. In: Swaiman KF, Ashwal S (eds.). Pediatric neurology. Principles and practice. 3rd ed. St. Louis: Mosby; 1999. p. 191-204.
Watanabe K, Miyazaki S, Hara K, Hakamada S: Behavioral state cycles, background EEGs and prognosis of newborns with perinatal hypoxia. Electroenceph Clin Neurophysiol. 1980; 49:618-625.
Flores-Compadre JL, Cruz F, Orozco G, Vélez A. Hipoxia perinatal y su impacto en el neurodesarrollo. Rev. Chil Neuropsicol. 2013; 8:26-31.
Nagdyman N, Kömen W, Ko H-K, Müller C, Obladen M: Early biochemical indicators of hypoxicischemic encephalopathy after birth asphyxia. Pediatr Res. 49:502-506, 2001.
Azzopardi D. Clinical managment of the baby with hypoxic ischaemic encephalopathy. Early Human Development. 2010; 86: 345-350. doi: 10.1016/j.earlhumdev.2010.05.008
Delfino A, Weinberger M, Delucchi G, Campo S, Bargeeño M, Filgueira L. et al. Seguimiento de recién nacidos con asfixia perinatal. Archivos de Pediatría de Uruguay. 2010; 81: 73-77.
James A, Cherian S. Pathophysiology of perinatal hypoxia-ischaema. Paediatrics and Child Health. 2010; 20: 351-355.
Martínez-Biarge M, Diez-Sebastian J, Rutherford M, Cowan F. Outcomes after central grey matter injury in term perinatal hypoxic ischemic encephalopathy. Early Human Development 2010; 86: 675-682. doi: 10.1016/j.earlhumdev.2010.08.013.
Swaiman KF, Russman BS. Cerebral Palsy. In: Swaiman KF, Ashwal S (eds.). Pediatric neurology. Principles and practice. 3rd ed. St. Louis: Mosby; 1999. p. 312-324.
Manganaro R, Mami C, Gemelli M. The validity of the Apgar Scores in the assessment of asphyxia at birth. Eur J Obstet Gynecol Reprod Biol. 1994;54:99-102.
Nelson KB, Ellemberg JH. Apgar score as a predictor of chronic neurologic disability. Pediatrics. 1981;68:36- 44.
González de Dios J, Moya M, Vioque J. Factores de riesgo predictivos de secuelas neurológiccas en recién nacidos a término con asfixia perinatal. Rev neurol. 2001; 32:210-216.
Campistol J. Convulsiones y síndromes epilépticos del recién nacido. Formas de presentación, protocolo de estudio y tratamiento. Rev Neurol. 2000; 31 (7):624-631.
Sheth RD, Hobbs GR, Mullett M. Neonatal Seizures: incidence, onset and etiology by gestional age. J. Perinatol. 1999;19: 40-3.
Allen MC. The high Risk infant. The child with developmental disabilities. Pediatr Clin North Am. 1993; 40: 479-490.
Sarnat H, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976; 33: 696-705.
Bastidas JA. Asfixia perinatal. In Manual de protocolos en neonatología. Starck C, Montes HF (eds.) Cali: Fundación Cirena; 1996p. 275-282.
Campistol J, De Jaro P, Póo P, Kraurel J, Fernández Álvarez E. Convulsiones neonatales. Formas de presentación y evolución. Rev Neurol. 1994; 22: 171-175.
Lombroso CT. Neonatal sizures: a clinician´s overview. Brain Dev. 1996; 18:1-28.
Protocolos Diagnóstico Terapéuticos de la AEP: Neonatología. Asociación Española de Pediatría. 2008 www.aeped.es/protocolos/
Jiménez R, Figueras J, Cañadell D, Botet F, Cruz M. Factores pronósticos en la encefalopatía hipóxico isquémicas del recién nacido a término. An Esp Pediatr. 1989;31:189-195.
Andre M, Debruille C, Vert P, Grunenwald O. Souffrance foetale aiguë et déficiences mentales. Etude prospective. Arch Fr Pediatr. 1981; 38: 323-329.
Rakshasbhuvankar A, Paul S, Nagarajan L, Ghosh S, Rao S. Amplitude-integrated EEG for detection of neonatal seizures: a systematic review. Seizure 2015; DOI of original article: http://dx.doi.org/10.1016/j. seizure.2015.09.014
Perrone S, Bracci R, Buoncore G. New biomarkers oof fetal-neonatal hypoxic stress. Acta Pediatr Suppl. 2002;91 (438):135-8.
Salinas Álvarez ML, Peñaloza Ochoa L. Frecuencia de desviaciones del neurodesarrollo a los 18 meses de edad en pacientes con alto riesgo neurológico que acuden a estimulación temprana. Bol Med Infant Mex. 2007; 64: 214-220.