2018, Number 07
<< Back Next >>
Ginecol Obstet Mex 2018; 86 (07)
Vulvar cancer. Impact of surgical treatment: experience with 151 patients
Torres-Lobatón A, Vázquez-Tinajero A, Jiménez-Arroyo EP, Barra-Martínez R, Oliva-Posada JC, Morgan-Ortiz F
Language: Spanish
References: 18
Page: 423-433
PDF size: 324.88 Kb.
ABSTRACT
Objective: The present study is a review of our experience of the surgical options
for vulvar cancer using The International Federation of Gynecology and Obstetrics
(FIGO) classification.
Materials and Methods: Retrospective analysis of records of patients diagnosed
with vulvar carcinoma operated with or without coadyuvance in the Oncology service
of the General Hospital of Mexico in a span of 34 years. For the statistical analysis, the
Epi Info version 7.2 program was used.
Results: Patients were divided into groups, those with pre-invasion or minimal
invasion disease were resolved with local excision or simple vulvectomy 24 (16%).
Patients with invasive cancer were treated with conservative surgery with or without
unilateral lymph node dissection 16 (15%); radical vulvectomy with inguino femoral
lymphadenectomy 94 (62%) (47 block surgeries and 47 with separate incision); ultraradical
surgery 11 (7%) (6 abdomino-perineal resections and 5 pelvic exenterations).
127 patients had follow - up and 62 of them had a disease-free survival rate of 30
months (48.8%). The overall survival in pre-invasion or minimal invasion disease were
91.3% (21/23), in stage IB-II 75.5% (37/49), in stage III 31.7% (13/41) (p=0.00007)
and in stage IVA 21.4% ( 3/14 ).
Conclusions: Although a more individualized and less radical treatment is suggested,
in this series only 14.5% of patients, could be resolved with conservative
surgery. In addition, the lymph node status was the most important prognostic factor
for survival.
REFERENCES
Bailey Claire, Luesley David. Squamous vulvar cancer an update. The Obstetrician & Gynecologist 2013;15:227-31
Alkatout I, Shubert M, Garbrecht N, Weigel TM, Jonat W, Mundhenke Ch, et al. Vulvar cancer: epidemiology, clinical presentation, and management options. Int J Women´s Health. 2015;7:305-313.
Hacker FN, Eifel JP, van der Velden J. Cancer of the vulva FIGO Cancer Report 2012. Int J Gynecol Obstet. 2012 119S2:S90-S96.
Facts and Figures. Estimated Number of New Cancer Cases and Deaths by Sex, US, 2018. National Cancer Institute. 2018. p.4.
Fernández CSB, Leon AG, Herrera TMC, et al. Perfil Epidemiológico de losTumores Malignos en México. Dirección General de Epidemiología ( SINAI/SINAVE/DGE/Salud ). México D.F: Secretaría de Salud; 2011.p.46-122.
Torres LA, Amoretti C, Morgan OF. Cáncer Ginecológico: Evolución de suFrecuencia relativa en una Institución de alta especialidad. Gac. Mex. Oncol. 2014;13:222-228.
Lee J, Kim HS, Kim G, Yu M, Park ChD, Yoon HJ et al. Treatment outcome in patients with vulvar cancer: comparison of concurrent radiotherapy to postoperative radiotherapy. Radiat OncolJ. 2012;30:20-26.
Baicchi G, Rocha MR. Vulvar cancer Surgery. Curr Opin Obstet Gynecol. 2014;26:9-17
Hacker FN, Blomfield P. Surgical Techniques for Vulvar Cancer. In: Ali Ayhan, Nicholas Reed, Murat Gultekin, Polat Dursun, Editors: Textbook of Gynaecological Oncology Gunes Publishing 2nd edition ESGO, 2011.p.541-551.
Vulvar Cancer. Principles ofSurgery and Overview. NCCN Guidelines Version 1.2018. B.1-4 and MS.2-10.
BrammenL, Staudenherz A, Poloterauer S, Dolliner P, Grim Ch Reinthaller A, et al. Sentinel Lymph node detection in vulvar cancer patients: A 20 years analysis. Hell J Nud Med 2014;17: 184-189.
Hensley L. Martee. Vulvar Cancer. In: Gynecologic CancersASCO- SEP. 2016. Vol. 4 Chap 11. p.351
Torres LA, Mendoza TA, Palacios CA. Tratamiento quirúrgico del cáncer de la vulva. Experiencia con 43 casos. Ginecol Obstet Méx. 1983;319:287-296.
Salazar B I, Salazar CEJ, López AA, Villavicencio VV, Coronel MJ, Candelaria HM et al. Manejo quirúrgico inicial del carcinoma epidermoide vulvar. Gac Med Mex.2016;152:297- 303.
Icheletti L, Preti M. Surgery ofvulvar cancer.Best Practice & Research Clin Obstet and Gynaecol. 2014;28:1074- 1087.
Rao Y,Chin Re-I, Hui C, Mutch DG, Powell MA, Schwarz JK, et al. Improved survival with definitive chemoradiation compared to definitive radiation alone in squamous cell carcinoma of the vulva: A review of The National Cancer Database. Gynecol Oncol 2017;146:572-579.
Kaban A, Kaban I, Afsar S. Surgical management of squamous cell vulvar cancer without clitoris uretra o anus involvement. Gynecol Oncol Reports.2017;20:41-46.
O´Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R . Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical. Chemotherapy and radiotherapy alternatives. an international collaborative RCT destined for true “too difficult to do”. Gynecol Oncol.2017;144:438-447.