2007, Number 1
<< Back
Bol Col Mex Urol 2007; 22 (1)
Abordaje toracoabdominal en carcinoma renal de células claras con trombo en vena cava supradiafragmático. Reporte de un caso
Neri PE, Chavarría MJJ, Errejón DA
Language: Spanish
References: 36
Page: 42-46
PDF size: 321.95 Kb.
ABSTRACT
Introduction: Renal cell carcinoma is responsible for 3% of all malignant processes in the adults. A singular
characteristic is the commitment of venous system that generally is pronounced in tumoral thrombus form within
renal or inferior cava vein present in near 4 to 15% of the cases. Thoraco-abdominal access for surgical removal
of the kidney along with tumoral thrombus is a recommended treatment modality to facilitate the surgical exhibition.
A singular characteristic is the commitment of venous system that generally is pronounced in tumoral thrombus
form within renal or inferior cava vein present in near 4 to 15% of the cases.
We present the case: of a patient
with renal cells carcinoma with superior cava vein thrombus that was treated in multidisciplinary form. Left
radical nephrectomy was made in addition to thrombectomy by means of thoraco-abdominal mid incision and
support of extracorporeal circulation pump, with a surgical time of 8 hours, transoperatory bleeding of 1,200 cc,
needing transfusion of two globular packages and support of four days in coronary cares, withdrawing from the
hospital seven days postsurgery. Hystopathologic report was clear cells renal carcinoma with invasion to
renal capsule, renal vein wall with tumoral infiltration, three lymphatic ganglia with tumoral activity. Left
suprarrenal gland free of tumor (pT4 N2 M0 EC IV). To seven months of the surgery the patient is with ECOG 0
and without evidence of tumoral activity. The boarding is individualized according to the surgeon’s experience,
exhibition and favorable vascular control. Thoraco-abdominal access has favored proximal control and exhibition
of thrombus in level 3. The mid sternotomy with early control of the inferior intrapericardial cava vein has been
recommended in thrombus of level 3 as well as the utility of cardiopulmonary bypass.
Conclusions: Considered
three years survival is 71%, free disease period 42%, mortality 22% in patients without synchronous metastasis evidence
demonstrates that the affectation of renal or inferior cava vein alone, in absence of ganglionary metastasis or at a
distance it does not affect of adverse form the prognostic.
REFERENCES
Parekh D, Cookson M, et al. Renal cell carcinoma with renal vein and inferior vena caval involvement: clinicopathological features, surgical techniques and outcomes. J Urol 2005; 73: 1897-1902.
Marshall FF, Dietrick DD, Baumgartner WA, Reitz BA. Surgical management of renal cell carcinoma with intracaval neoplastic extension above the hepatic veins. J Urol 1988; 139: 1166.
Staehler G, Brkovic D. The role of radical surgery for renal cell carcinoma with extension into the vena cava. J Urol 2000; 63(6): 1671 -5.
Kaplan S, Ekici S, Dogan R, Demircin M, Ozen H, Pasaoglu I. Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus. Am J Surg 2002; 183: 292.
Montie JE, el Ammar R, Pontes JE, Medendorp SV, Novick AC, Streem SB, et al. Renal cell carcinoma with inferior vena cava tumor thrombi. Surg Gynecol Obstet 1991; 173: 107.
Belis JA, Levinson ME, Pae WE Jr. Complete radical nephrectomy and vena caval thrombectomy during circulatory arrest. J Urol 2000; 163: 434.
Skinner DG, Pfister RF, Colvin R. Extension of renal cell carcinoma into the vena cava: the rationale for aggressive surgical management. J Urol 1972; 107: 711.
Zisman A, Wieder JA, Pantuck AJ, Chao DH, Dorey F, Said JW, Gitlitz BJ, de Kernion JB, Figlin RA, Belldegrun AS. Renal cell carcinoma with tumor thrombus extension: Biology, Role of Nephrectomy and Response to Immunotherapy. J Urol 2003; 169(3): 909-16.
Zisman A, Pantuck AJ, Chao DH, Wieder JA, Dorey F, Said JW, de Kernion JB, Figlin R, Belldegrun AS. [S] Renal cell carcinoma with tumor thrombus: Is cytoreductive nephrectomy for advanced disease associated with an increased complication rate? J Urol 2002; 168(3): 962-7.
10.Skinner DG, Pritchett TR, Lieskovsky G, Boyd SD, Stiles QR. Vena caval involvement by renal cell carcinoma. Surgical resection provides meaningful long-term survival. Ann Surg 1989; 210: 387.
11.Naitoh J, Kaplan A, Dorey F, Figlin R, Belldegrun A. Metastatic renal cell carcinoma with concurren! inferior vena caval invasion: long-term survival after combination therapy with radical nephrectomy, vena caval thrombectomy and postoperative immunotherapy. J Urol 1999; 162(1): 46-50.
12.Flanigan RC, Mickisch G, Sylvester R, Tangen C, Van Poppel H, Crawford ED. Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol 2004; 171(3): 1071-6.
13.Gettman MT, Boelter CW, Cheville JC, Zincke H, Bryant SC, Blute ML. Charlson co-morbidity Index as a predictor of outcome after surgery for renal cell carcinoma with renal vein, vena cava or right atrium extension. J Urol 2003; 169(4): 1282-6.
14.Vaidya A, Ciancio G, Soloway M. Surgical techniques for treating a renal neoplasm invading the inferior vena cava. J Urol 2003; 169(2): 435-44.
15.Neves RJ, Zincke H. Surgical treatment of renal cancer with vena cava extension. Br J Urol 1987; 59: 390.
16.Fraser ET, Coakley FV, Meng MV, Yeh BM, Joe BN, Qayyum A. Computed tomography and magnetic resonance imaging of inferior vena caval thrombus associated with metastasis to the kidney. J Comp Assis Tom 2004; 28(1): 131-3.
17.Oto A, Herts BR, Remer EM, Novick AC. Inferior vena cava tumor thrombus in renal cell carcinoma: staging by MR imaging and impact on surgical treatment. AJR Am J Roentgenol 1998; 171: 1619.
18.Fitzgerald JM, Tripathy U, Svensson LG, Libertino JA. Radical nephrectomy with vena caval thrombectomy using a minimal access approach for cardiopulmonary bypass. J Urol 1998; 159(4): 1292-3.
19.Hatcher PA, Anderson EE, Paulson DF, Carson CC, Robertson JE. Surgical management and prognosis of renal cell carcinoma invading the vena cava. J Urol 1991; 145: 20.
20.Baumgartner F, Scott R, Zane R, Gelman J, Rajfer J, Ages B, et al. Modified venous bypass technique for resection of renal and adrenal carcinomas with involvement of the inferior vena cava. Eur J Surg 1996; 162: 59.
21.Kobayashi K, Sato T, Sunaoshi K, Takahashi A, Tamakawa M. Spontaneous regression of primary renal cell carcinoma with inferior vena caval tumor thrombus. J Urol 2002; 167(1): 242-3.
22.Bissada NK, Yakout HH, Babanouri, A, Elsalamony T, Fahmy W, Gunham M, et al. Long-term experience with management of renal cell carcinoma involving the inferior vena cava. Urology 2003; 61: 89.
23.Messing EM, Manola J, Wilding G, Propert K, Fleischmann J, Crawford ED, Pontes JE, Hahn R, Trump D. Phase III study of inferior alfa-NL as adjuvant treatment for resectable renal cell carcinoma: An eastern cooperative oncology group/ intergroup trial. J Clin Oncol 2003; 21(7): 1214-22.
24.Sosa RE, Muecke EC, Vaughan ED Jr, McCarron JP Jr. Renal cell carcinoma extending into the inferior vena cava: the prognostic significance of the level of vena caval involvement. J Urol 1984; 132: 1097.
25.Libertino JA, Zinman L, Watkins E Jr. Long-term results of resection of renal cell cancer with extension into inferior vena cava. J Urol 1987; 137: 21.
26.Vaidya A, Ciancio G, Soloway M. Trans-abdominal approach to resection of vena caval thrombus from a renal cell carcinoma. Surgical pitfalls and their management. BJU International 2004; Supplement. 93(Supplement 4): 29.
27.Swierzewski DJ, Swierzewski MJ, Libertino JA. Radical nephrectomy in patients with renal cell carcinoma with venous, vena caval, and atrial extension. Am J Surg 1994; 168: 205.
28.Ciancio G, Vaidya A, Savoie M, Soloway M. Management of renal cell carcinoma with level III thrombus in the inferior vena cava. J Urol 2002; 168(4, Parí 1 of 2): 1374-7.
29.Aslam SS, Teh J, Nargund VH, Lumley JSP, Hendry WF, Reznek RH. Assessment of tumor invasion of the vena caval wall in renal cell carcinoma cases by magnetic resonance imaging. J Urol 2002; 167(3): 1271-5.
30.Glazer AA, Novick AC. Long-term follow up after surgical treatment for renal cell carcinoma extending into the right atrium. J fro/1996; 155: 448.
31.Rodríguez JL, López JM, Proctor MC, Conley JLM, Gerndt SJ, Marx MV, Taheri PA, Greenfield LJ. Early placement of prophylactic vena caval filters in injured patients at high risk for pulmonary embolism. Journal of Trauma-lnjury Infection & Cntical Care 1996; 40(5): 797-804.
32.Fergany AF, GilI IS, Schweizer DK, Kaouk JH, Elfettouh HA, Cherullo EE, Meraney AM, Sung GT. Laparoscopic radical nephrectomy with level II vena caval thrombectomy: Survival porcine study. J Urol 2002; 168(6): 2629-31.
33.Sundaram ChP, Rehman J, Landman J, Oh J. Hand assisted laparoscopic radical nephrectomy for renal cell carcinoma with inferior vena caval thrombus. J Urol 2002; 168(1): 176-9.
34.Sigman DB, Hasnain JU, del Pizzo JJ, Sklar GN. Real-time transesophageal echocardiography for intraoperative surveillance of patients with renal cell carcinoma and vena caval extension undergoing radical nephrectomy. J Urol 1999; 161(1): 36-8.
35.Seo IY, Ono Y, Yoshikawa Y, Saika T, Yoshino Y, Katsuno S, Araki H, Ohshima S. Early experience of laparoscopic radical nephrectomy for T3b renal cell carcinoma. Int J Urol 2004; 11(9): 778-81.
36.Curti BD. Renal cell carcinoma. JAMA 2004; 292(1): 97-100.