Mendoza M, Eblen-Zajjur A

Language: Spanish
References: 57
Page: 23-38
PDF size: 757.80 Kb.

ABSTRACT

The normal aging leads to a decrease in brain volume, gray matter cortical thinning and altered signal intensity on MRI. Efforts are needed to describe what normal brain aging is and which parameter to use. The aim was to use central tendency and dispersion values of T2-FLAIR-MRI signal intensity profiles from frontal, parietal, occipital and cingulate cortices and correlate them with age and gender. Images from a total of 88 healthy subjects (22-80 years old, 58 females, 30 males) were evaluated with 1.5T MRI FLAIR sequences obtaining mean and coefficient of variation (CV) signal intensities values from linear profiles of frontal, parietal, occipital and cingulate cortices. Correlation and regression analysis were performed between age and gender. FLAIR signal mean was negatively while CV was positively related to age for frontal, parietal and occipital cortex. Cingulate cortex did not show significant changes. These changes were more intense for females and for left hemisphere. Normal aging impacts inversely mean and CV values from cortical FLAIR MRI image. The regression equations obtained could be used to detect abnormal age-related cortical changes.

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