2018, Number 1
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Arch Neurocien 2018; 23 (1)
Macroscopic lesions observed in thalamic nuclei after Status Epilepticus by pilocarpine
López-Hernández E, Gallegos-Santiago M, Solís H
Language: Spanish
References: 20
Page: 16-22
PDF size: 515.02 Kb.
ABSTRACT
Background: the Status Epilepticus (SE) is an acute event and constitutes a neurological
emergency that requires rapid and effective treatment in order to avoid neuronal damage.
It is common that after a period of SE there are structural and functional alterations in neural
networks that culminate with the appearance of spontaneous seizures. Within the structures that
are affected is the limbic system and in particular the amygdala of the temporal lobe and the
hippocampus. Another structure that is affected after the SE is the thalamus that is considered
modulator of seizures, and is involved in the pathophysiology of seizures type absences.
Objective: to study that thalamic nuclei are affected after inducing SE by the administration of
pilocarpine in rats subjected to different times of duration of the SE.
Material and methods: Assess the thalamic nuclei with presence of
hemorrhagic foci macroscopic,
after 1, 2, 3 and 4 hs PosSE.
Results: the five thalamic nuclei that had
hemorrhagic foci regardless of the duration of the SE were
the posterior, the reticular, the ventrolateral, the ventroposterolateral and the ventroposteromedial.
We also observed that the animals showed motor deficit that was correlated with the duration
of the SE, that is to say, the motor defict was higher in the animals that had more hours of SE.
Discussion and conclusion: the observed
hemorrhagic foci may correspond to microbleeds due to
the rupture of small blood vessels, which possibly condition the motor deficit and several changes
in the neural network.
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