Ovies CG, Martínez SCA, Lardoext FR, Monteagudo PG

Language: Spanish
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ABSTRACT

Introduction: it is known that women with polycystic ovary syndrome have a higher risk of developing cardiometabolic complications, but there is also evidence that their relatives are more prone to those too.
Objective: to identify the frequency of components of the metabolic syndrome in relatives of women with polycystic ovary syndrome.
Methods: a cross-sectional, descriptive study was conducted in the National Institute of Endocrinology from 2012 to 2014, which included 25 women with polycystic ovary syndrome and 36 of their relatives (cases); and 50 women without polycystic ovary syndrome and 65 of their relatives (controls). The relatives were inquired about a history of hypertension, diabetes mellitus, dyslipidemia; and blood pressure, weight and height were measured. An oral glucose tolerance test was carried out for measuring glycaemia and insulinaemia (excepting those suffering from diabetes mellitus), and cholesterol and triglycerides. Frequencies were determined and chi2 was used for comparisons.
Results: 76.0 % of women with polycystic ovary syndrome reported a relative with diabetes mellitus, 80.0 % a relative with arterial hypertension, and 20.0 % a relative with a lipid disorder. In healthy women, 28.0 % of them had a family member with diabetes mellitus, 36.0 % a relative with arterial hypertension, and 12.0 % a relative with dyslipidemia. According to the oral glucose tolerance´s test, impaired glucose in fasting was diagnosed in 16.7 % of the relatives of women with polycystic ovary syndrome, and in 12.3 % of the relatives of healthy women. There were 19.4 % of the relatives of the cases with impaired glucose tolerance, and 3.1 % of the controls. There were 5.6 % of the relatives of the women with polycystic ovary syndrome with diabetes mellitus and 1.5 % of those of the healthy ones. In 47.2 % of the relatives of women with polycystic ovary syndrome and 21.5 % of those of healthy women, hypertriglyceridemia was detected.
Conclusions: the frequency of metabolic syndrome components in family members of women with polycystic ovary syndrome is higher when compared to the relatives of women who do not have it.