Alvarado NA, Hernández UMA

Language: Spanish
References: 43
Page: 166-170
PDF size: 254.44 Kb.

ABSTRACT

CD1 molecules are classified in two groups: CD1a, CD1b, CD1c molecules are included in group 1, and CD1d is in group 2, they interact with T and NKT cells, respectively. The difference between CD1 and MHC molecules is that CD1 presents lipid and glycolipid mycobacterial antigens. The CD1 molecules are located in intracellular compartments of APCs. There is controversy about the processing of lipidic antigens which influence the presentation and recognition by T cells through TCR. In spite of several studies in experimental models, the mechanisms to recognize the self and nonself glycolipids during mycobacterial infections have not been described yet. This review shows the importance of the antigen presentation by CD1 molecules and its relevance in the immune response against intracellular patogens such as mycobacteria.

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