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Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara y del OPD Hospitales Civiles de Guadalajara

2005, Number s1

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Inv Salud 2005; 7 (s1)

Genetic Susceptibility to Cirrhosis

Parra RI, Martínez LE, Ruiz MB, Panduro CA

Language: Spanish
References: 54
Page: 48-54
PDF size: 260.83 Kb.


ABSTRACT

Obesity and diabetes are common our population and are frequently associated with nonalcoholic fatty liver disease (NAFLD), which includes nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Nonalcoholic fatty liver is usually considered bening, but nonalcoholic steatohepatitis is recognized as a precursor to more severe liver disease and sometimes evolves to cryptogenic cirrhosis or also known as liver disease of undefined etiology. Cryptogenic cirrhosis constitutes 3-30% of all cases of cirrhosis. It is typically diagnosed after an exhaustive evaluation including serologic diagnostic to exclude identifiable etiologies and usually after a liver biopsy. The major risk factors for cryptogenic cirrhosis are nonalcoholic steatohepatitis (NASH), obesity, diabetes and hyperlipidemia. Genetic factors could explain the progression of steatosis to cirrhosis. Polymorphisms in genes encoding cytokines, leptin, keratins, iron metabolism proteins, can explain susceptibility to the development of cirrhosis.


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