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Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara y del OPD Hospitales Civiles de Guadalajara

2005, Number s1

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Inv Salud 2005; 7 (s1)

Nonalcoholic Steatohepatitis

Martínez LE, Domínguez RJA, Hernández NZH, Panduro CA

Language: Spanish
References: 67
Page: 40-47
PDF size: 223.05 Kb.


ABSTRACT

In 1980, Ludwing and colleagues described patients who lacked a history of alcohol consumption but had findings on liver biopsy that could not be distinguished from those patients with alcoholic hepatitis. Since then, “nonalcoholic steatohepatitis” (NASH) was coined. Diagnostic criteria for NASH proposed by Powell in 1990 included a liver biopsy specimen that shows macrovesicular fatty degeneration with inflamation, without evidence of negligible alcohol consumption and absence of previous infection with hepatitis B o C virus. The true prevalence of NASH in the general populations is unknow, but it has been reported that 1.2 to 9% of patients undergoing liver biopsy; additionally it is believed that NASH prevalence would incidence it asymptomatic patients would be studied. The anormality frecuently observed in the subjets is elevated plasma liver enzyme level. NASH has been described most frequently in females and it has been asociated metabolic diseases, such as insulin resistance, obesity, DM2, hyperlipidemias. Pathogenesis of NASH is not clear, but some authors have hypothesized mechanimics that involve free fatty acid metabolism.


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