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Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara y del OPD Hospitales Civiles de Guadalajara

2005, Número s1

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Inv Salud 2005; 7 (s1)


Mecanismos moleculares de la regulación transcripcional de colágena α1(I) por las células estelares hepáticas

Hernández NZH, Martínez LE, Domínguez RJA

Idioma: Español
Referencias bibliográficas: 38
Paginas: 33-39
Archivo PDF: 261.68 Kb.


RESUMEN

Las células estelares hepáticas (CEH), se localizan en el interior del espacio de Disse del sinusoide hepático. En estado de reposo, producen las proteínas de tejido conectivo que forman el estroma hepático y es el principal depósito de vitamina A. Sin embargo, ante un estímulo nocivo, sufre un proceso de cambio fenotípico conocido como activación. Las células activadas se caracterizan por el incremento de la expresión de la colágena tipo I, lo que en estado crónico lleva a la fibrosis o cirrosis del hígado. Actualmente, se sabe que la activación de estas células depende de un grupo de citocinas (PDGF-BB, TGF-β1,TNF-α) producidas por las células de kuppfer o incluso por las mismas CEH, que a su vez, activan a un grupo de factores transcripcionales que se unen al promotor de las colágenas alfa 1(I) y 2(I) y regulan la expresión del gen.


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