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Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara y del OPD Hospitales Civiles de Guadalajara

2005, Number s1

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Inv Salud 2005; 7 (s1)

Molecular mechanisms of the transcripcional regulation of collagen á1(I) by hepatic stellate cells

Hernández NZH, Martínez LE, Domínguez RJA

Language: Spanish
References: 38
Page: 33-39
PDF size: 261.68 Kb.


ABSTRACT

Hepatic stellate cells (HSC) are localized in Disse space of the hepatic sinusoid. Normally, The quiescent HSC produce the connective tissue proteins of the hepatic stroma and it is the principal storage of vitamin A. However, after a noxious stimulus the HSC is able to modify its phenotype and it is known as HSC activation. This activation is characterized by the increased expression of collagen type I that eventually lead to fibrosis or cirrhosis. The cell activation, directly depend of the next cytokines: PDGF-BB, TGF-β1 and TNF-α. The cytokines are produced by Kuppfer cells and HSC. They act trough the activation of several transcription factor proteins localized inside of HSC, that bind at the promoter level and regulate the gene expression of α-collagen 1(I) and α-collagen 2(I).


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