medigraphic.com
ISSN 0016-3813 (Print)

2018, Number 2

<< Back Next >>

Gac Med Mex 2018; 154 (2)

Estudio clínico de 200 pacientes con estomatitis aftosa recurrente

Rodríguez-Archilla A, Raissouni T

Language: Spanish
References: 45
Page: 165-171
PDF size: 201.07 Kb.


ABSTRACT

Introduction: Recurrent aphthous stomatitis (RAS) affects approximately 20% of the general population. Its etiology is still unknown. Objective: To analyze this entity’s clinical features. Method: Data such as age, gender, family history of RAS, age at first episode onset, prodromal symptoms, number, size, morphology and localization of lesions, RAS clinical form, annual rate of recurrence, predisposing factors, symptoms and time for symptoms and lesions disappearance were assessed in 200 patients with RAS. Results: Patients had RAS minor forms. Main clinical characteristics were family history of RAS (89%), first episode at ≥ 10 years of age (69%), prodromal symptoms (66%), one lesion per episode (63%), ‹ 0.5 cm lesions (64%), rounded morphology (55%), localization at the tongue (27%), 3 recurrent episodes per year (36%), stress as predisposing factor (34%), symptom disappearance in 2 days (54%) and healing of lesions in 8 days (40%). Conclusion: Even when RAS is a common disorder of the oral mucosa, there is no curative treatment available. Therapeutic measures seek to reduce the pain and size of lesions, accelerate the time of recovery and decrease the rate of relapses.


REFERENCES

  1. Porter SR, Scully C, Pedersen A. Recurrent aphthous stomatitis. Crit Rev Oral Biol Med. 1998;9(3):306-21.

  2. Ship JA, Chavez EM, Doerr PA, Henson BS, Sarmadi M. Recurrent aphthous stomatitis. Quintessence Int. 2000;31(2):95-112.

  3. Jurge S, Kuffer R, Scully C, Porter SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis. 2006;12(1):1-21.

  4. Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am. 2014;58(2):281-297.

  5. Baccaglini L, Lalla RV, Bruce AJ, Sartori-Valinotti JC, Latortue MC, Carrozzo M, et al. Urban legends: recurrent aphthous stomatitis. Oral Dis. 2011;17(8):755-770.

  6. Chavan M, Jain H, Diwan N, Khedkar S, Shete A, Durkar S. Recurrent aphthous stomatitis: a review. J Oral Pathol Med. 2012;41(8):577-583.

  7. Porter SR, Hegarty A, Kaliakatsou F, Hodgson TA, Scully C. Recurrent aphthous stomatitis. Clin Dermatol. 2000;18(5):569-578.

  8. Albanidou-Farmaki E, Deligiannidis A, Markopoulos AK, Katsares V, Farmakis K, Parapanissiou E. HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance? Int J Immunogenet. 2008;35(6):427-432.

  9. Preeti L, Magesh KT, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15(3):252-256.

  10. Huling LB, Baccaglini L, Choquette L, Feinn RS, Lalla RV. Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis. J Oral Pathol Med. 2012;41(2):149-152.

  11. McRobbie H, Hajek P, Gillison F. The relationship between smoking cessation and mouth ulcers. Nicotine Tob Res. 2004;6(4):655-659.

  12. Landesberg R, Fallon M, Insel R. Alterations of T helper/inducer and T suppressor/inducer cells in patients with recurrent aphthous ulcers. Oral Surg Oral Med Oral Pathol. 1990;69(2):205-208.

  13. Bachtiar EW, Cornain S, Siregar B, Raharjo TW. Decreased CD4+/ CD8+ ratio in major type of recurrent aphthous ulcers: comparing major to minor types of ulcers. Asian Pac J Allergy Immunol. 1998; 16(2-3):75-79.

  14. Scully C, Yap PL, Boyle P. IgE and IgD concentrations in patients with recurrent aphthous stomatitis. Arch Dermatol. 1983;119(1):31-34.

  15. Rodríguez-Archilla A, Urquía M, Gómez-Moreno G, Ceballos A. Anti-DNA antibodies and circulating immune complexes (C1q-IgG) in recurrent aphthous stomatitis. Bull Group Int Rech Sci Stomatol Odontol. 1994;37(1-2):31-35.

  16. Yamamoto T, Yoneda K, Ueta E, Osaki T. Serum cytokines, interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in oral disorders. Oral Surg Oral Med Oral Pathol. 1994;78(6):727-35.

  17. Healy CM, Enobakhare B, Haskard DO, Thornhill MH. Raised levels of circulating VCAM-1 and circulating E-selectin in patients with recurrent oral ulceration. J Oral Pathol Med. 1997;26(1):23-28.

  18. Healy CM, Thornhill MH. Induction of adhesion molecule expression on blood vessels and keratinocytes in recurrent oral ulceration. J Oral Pathol Med. 1999;28(1):5-11.

  19. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg. 2008;46(3):198-206.

  20. Scully C. Clinical practice. Aphthous ulceration. N Engl J Med. 2006;355(2):165-172.

  21. Taylor J, Glenny AM, Walsh T, Brocklehurst P, Riley P, Gorodkin R, et al. Interventions for the management of oral ulcers in Behçet’s disease. Cochrane Database Syst Rev. 2014;(9):CD011018.

  22. Maloney WJ, Raymond G, Hershkowitz D, Rochlen G. Oral and dental manifestations of celiac disease. N Y State Dent J. 2014;80(4):45-48.

  23. Burton MJ, Pollard AJ, Ramsden JD, Chong LY, Venekamp RP. Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). Cochrane Database Syst Rev. 2014;(9):CD008669.

  24. Chattopadhyay A, Chatterjee S. Risk indicators for recurrent aphthous ulcers among adults in the US. Community Dent Oral Epidemiol. 2007;35(2):152-159.

  25. Safadi RA. Prevalence of recurrent aphthous ulceration in Jordanian dental patients. BMC Oral Health. 2009;9:31.

  26. Brailo V, Boras VV, Cekić-Arambasin A. Rekurentne aftozne ulceracije: Analiza predisponirajucih cimbenika u 68 bolesnika. Liječ Vjesn. 2007;129:4-7.

  27. Oh SH, Han EC, Lee JH, Bang D. Comparison of the clinical features of recurrent aphthous stomatitis and Behçet’s disease. Clin Exp Dermatol. 2009;34(6) e208-e212.

  28. López-Jornet P, Camacho-Alonso F, Martos N. Hematological study of patients with aphthous stomatitis. Int J Dermatol. 2014;53(2):159-163.

  29. Gavic L, Cigic L, Biocina-Lukenda D, Gruden V, Gruden Pokupec JS. The role of anxiety, depression, and psychological stress on the clinical status of recurrent aphthous stomatitis and oral lichen planus. J Oral Pathol Med. 2014;43(6):410-417.

  30. Bratel J, Hakeberg M. Anamnestic findings from patients with recurrent aphthous stomatitis. Swed Dent J. 2014;38(3):143-149.

  31. McCullough MJ, Abdel-Hafeth S, Scully C. Recurrent aphthous stomatitis revisited; clinical features, associations, and new association with infant feeding practices? J Oral Pathol Med. 2007;36(10):615-620.

  32. Casiglia JM. Recurrent aphthous stomatitis: etiology, diagnosis and treatment. Gen Dent. 2002;50(2):157-166.

  33. Majorana A, Bardellini E, Flocchini P, Amadori F, Conti G, Campus G. Oral mucosal lesions in children from 0 to 12 years old: ten years’ experience. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(1):e13-e18.

  34. Slebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Arch Immunol Ther Exp (Warsz). 2014;62(3):205-215.

  35. Murray LN, Amedee RG. Recurrent aphthous stomatitis. J La State Med Soc. 2000;152(1):10-14.

  36. Piantanida EW, Samlaska CP. Recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82(5):472.

  37. Rees TD, Binnie WH. Recurrent aphthous stomatitis. Dermatol Clin. 1996;14(2):243-256.

  38. Bagán JV, Sanchis JM, Milián MA, Peñarrocha M, Silvestre FJ. Recurrent aphthous stomatitis. A study of the clinical characteristics of lesions in 93 cases. J Oral Pathol Med. 1991;20(8):395-397.

  39. Zain RB. Oral recurrent aphthous ulcers/stomatitis: prevalence in Malaysia and an epidemiological update. J Oral Sci. 2000;42(1):15-19.

  40. Axéll T, Henricsson V. The occurrence of recurrent aphthous ulcers in an adult Swedish population. Acta Odontol Scand. 1985;43(2):121-125.

  41. Lotufo MA, Lemos CA, Shimizu MT, Cabral R, Birman EG. Clinical evaluation of the topical use of propolis in recurrent minor aphthous ulceration. Cienc Odontol Bras. 2005;8(3):6-9.

  42. Ogura M, Yamamoto T, Morita M, Watanabe T. A case-control study on food intake of patients with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(1):45-49.

  43. Nolan A, Lamey PJ, Milligan KA, Forsyth A. Recurrent aphthous ulceration and food sensitivity. J Oral Pathol Med. 1991;20(10):473-475.

  44. Koybasi S, Parlak AH, Serin E, Yilmaz F, Serin D. Recurrent aphthous stomatitis: investigation of possible etiologic factors. Am J Otolaryngol. 2006;27(4):229-232.

  45. McCartan BE, Sullivan A. The association of menstrual cycle, pregnancy, and menopause with recurrent oral aphthous stomatitis: a review and critique. Obstet Gynecol. 1992;80(3 Pt 1):455-458.




2020     |     www.medigraphic.com