Ortiz-Ibarra FJ, Reyna-Figueroa J, Aldana-Cuevas RE, Lara-Sánchez J

Language: Spanish
References: 16
Page: 249-255
PDF size: 79.48 Kb.

ABSTRACT

Introduction. A great variety of cytokines are produced locally in the central nervous system in response to microbial infection, and their levels have been used as a diagnostic parameter of infection. Objectives: to determine the concentrations of interleukin-6 (IL-6) in cerebrospinal fluid (CSF) of newborns with bacterial meningitis and the effectiveness of the determination as a diagnostic tool.
Material and methods. This was a prospective study from December 2002 to July 2003, in the Instituto Nacional de Perinatologia (INPer), in which the concentrations of IL-6 in the CSF were measurered in newborns with a clinical diagnosis of sepsis.
Results. Fourteen out of 58 newborns attended during the study period had bacterial meningitis.The mean IL-6 concentration in the meningitis group was 9 994 pg/mL vs 15.4 pg/mL in the control group (P‹0.05). Sensitivity was (92%), the specificity (100%); the positive predictive value and area under the ROC curve support that IL-6 concentration of ›50 pg/mL in CSF are the cut-off level of neonatal bacterial meningitis.
The concentrations of IL-6 in the CSF were greater, demonstrating itself that concentrations of IL-6 equal or greater to 50 pg/mL have a sensitivity of 92% and a specificity of 100%, for the diagnosis of bacterial meningitis.
Conclusions. The determination of the concentration of IL-6 in CSF could be a useful tool in the meningitis diagnosis; however CSF conventional analysis and culture are still the gold standard.

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