2017, Number S1
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Rev Cubana Pediatr 2017; 89 (S1)
Burden of hospital admissions and population for the community-acquired pneumonias in children aged less tan 5 years
Borroto GSM, Linares-Pérez N, Toledo-Romaní ME, Mirabal SM, Reyes SA, Abreu SG, Molina ÁN, Tamayo RCM, González FN, Ramos-Carpente LT
Language: Spanish
References: 28
Page: 107-118
PDF size: 169.36 Kb.
ABSTRACT
Introduction: community-acquired pneumonia is the fundamental cause of death in
children aged less than 5 years.
Objective: to estimate the burden of hospital admissions and population for
community-acquired pneumonia in hospitalized children aged less than 5 years from
2009 to 2015.
Methods: a mixed ecological descriptive study was conducted by using data from six
hospitals of the Sentinel Network of Surveillance and Evaluation of Vaccines in the
Pneumococcal Project of Cuba. The study population included all the hospitalized
patients younger than 5 years with diagnosis of X ray-confirmed community-acquired
pneumonia. Ratios of general hospitalization and intensive care unit hospitalization for
community-acquired pneumonia were calculated in breast-fed and pre-school children
per year of study, and the incidence rate of hospitalization was estimated by using the
reference population of every participating hospital and the confidence interval of 95
%. For every age group, the ratios reported in 2009 and 2015 for each indicator and
the reductions among the age groups were compared with a test of ratio comparison.
Results: in the study period, 9.6 % of the total number of hospitalizations in children
aged less than 5 years were bacterial pneumonia cases; 13.9 % went to the 1-4
years-old children. There was a reduction of 64.5 % for the infant group under one
year of age (p< 0.0001) and of 74.1 % (p< 0,0001) for the 1-4 year group. The
accrued incidence rate of hospitalizations for the community-acquired pneumonia in
the first group was 4 549 x 105 pop (95 % CI= 4 452-4 647) and for the second
group was 1 368 x 105 pop (95 % CI= 1 340-1 395).
Conclusions: these results represent a step forward in order to demonstrate the
need of pneumonia surveillance and its usefulness for measurement of the impact of a
Cuban pneumococcal vaccine.
REFERENCES
Walker CL, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, et al. Global burden of childhood pneumonia and diarrhea. Lancet. 2013;381:1405-16.
OMS. Neumonía [homepage en Internet]; Nota descriptiva, noviembre de 2016 [citado 14 de Marzo de 2016]. Disponible en: http://www.who.int/mediacentre/factsheets/fs331/es/
Nair H, Simões EA, Rudan I, Gessner BD, Azziz-Baumgartner E, Zhang JSF, et al. Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. The Lancet. 2013;381:1380-90.
Niederman MS, Krilov LR. Acute lower respiratory infections in developing countries. The Lancet. 2013;381(20):1341-2.
World Health Organization. Programme for the control of acute respiratory infections. Acute respiratory infections in children: case management in small hospitals in developing countries [homepage en Internet]; 1990 [citado 20 de Agosto de 2016]. Disponible en: http://apps.who.int/iris/bitstream/10665/61873/1/WHO_ARI_90.5.pdf
Cherian T, Mulholland EK, Carlin JB, Ostensen H, Amin R, Campo M, et al. Standardized interpretation of pediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies. Bull World Health Organ. 2005;83:353-9.
Cuba. Ministerio de Salud Pública (Minsap). Grupo Nacional de Pediatría, Grupo Nacional de Infectología, Comisión Nacional de Infecciones Respiratorias Agudas y Sociedad Cubana de Pediatría. Consenso Nacional para el Diagnóstico y Tratamiento de la Neumonía Adquirida en la Comunidad en Pediatría. La Habana; 2013.
Smith KR, Samet JM, Romieu I, Bruce N. Indoor air pollution in developing countries and acute lower respiratory infections in children. Thorax. 2000;55(6):518- 32.
Mizgerd JP. Acute lower respiratory tract infection. New England Journal of Medicine. 2008;358(7):716-27.
Dickinson F, Rodríguez M, Toraño G. Pneumococcal meningitis in Cuban children and adolescents: A fifteen years follow up. Pediatrics Research International Journal [serie en Internet]. 2015 [citado 28 de Agosto de 2016]; 2015. Article ID 596251, DOI: 10.5171/2015. Disponible en: http://www.ibimapublishing.com/journals/PRIJ/PRIJ.html
Pérez A, Dickinson F, Rodriguez M. Community acquired bacterial meningitis in Cuba: a follow up of a decade. BMC Infectious Diseases. 2010;10:130.
Cuba. Ministerio de Salud Pública (Minsap). Guía práctica para el sistema de vigilancia de las neumonías y meningitis bacterianas en menores de 5 años en Cuba. La Habana; 2006.
OPS. Informe Regional de SIREVA II, 2013: datos por país y por grupos de edad sobre las características de los aislamientos de Streptococcus pneumoniae, Haemophilus influenzae y Neisseria meningitidis en procesos invasores. Washington, D.C.: OPS; actualizado septiembre 12 de 2016:130-8.
Dotres CP, Puga R, Ricardo Y, Brono CR, Paredes B, Echemendía V, et al. Safety and preliminary immunogenicity of Cuban pneumococcal conjugate vaccine candidate in healthy children: A randomized phase I clinical trial. Vaccine. 2014;32(41):5266-70.
González N, Paredes B, Pérez S, Mirabal M, Rivero I, González C, et al. Safety and immunogenicity of Cuban antipneumococcal conjugate vaccine PCV7-TT in healthy adults. MEDICC Review. 2015;17(4):32-7.
Toraño G, Llanes R, Pías L, Abreu M, Valcárcel M. Serotipos de Streptococcus pneumoniae en Cuba y progresión de la resistencia a la penicilina. Rev Cubana Med Trop. 2010;62(2):157-60.
Johnson HL, Deloria-Knoll M, Levine OS, Stoszek SK, Freimanis Hance L, Reithinger R, et al. Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project. PLoS Medicine. 2010;7(10):1251.
O'Brien KL, Wolfson LJ, Watt JP, Henkle E, Deloria-Knoll M, McCall N, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. The Lancet. 2009;374(9693):893-902.
Oficina Nacional de Estadística e Información. Estadísticas de población de Cuba 2000-2015. República de Cuba. La Habana; 2015.
Arguedas A, Abdelnour A, Soley C, Jiménez E, Jiménez L, Porat N, et al. Vigilancia epidemiológica prospectiva de la enfermedad neumocócica invasora y de la neumonía en niños de San José, Costa Rica. Acta Méd Costarric, 2012;54(4):252-61.
Lagos R, Muñoz, A, Espinoza A, Dowes A, Ruttimann R, Colindres R, et al. Costos médicos directos de enfermedades neumocócicas invasoras y neumonías con diagnóstico radiológico en niños chilenos. Pan Am J Public Health. 2009;26(2):101- 11.
Griffin MR, Zhu Y, Moore M, Whitney CG, Grijalva C. U.S. Hospitalizations for Pneumonia after a Decade of Pneumococcal Vaccination. N Engl J Med. 2013;369:155-63.
Foy HM, Cooney MK, Allan I, Kenny GE. Rates of pneumonia during influenza epidemics in Seattle, 1964 to 1975. JAMA. 1979;241:253-8.
Murphy TF, Henderson FW, Clyde WA Jr, Collier AM, Denny FW. Pneumonia: an eleven-year study in a pediatric practice. Am J Epidemiol. 1981;113:12-2.
McConnochie KM, Hall CB, Barker WH. Lower respiratory tract illness in the first two years of life: epidemiologic patterns and costs in a suburban pediatric practice. Am J Public Health. 1988;78:34-9.
Toraño G, Pías L, Abreu M, Rodríguez M, Dickinson F, Valcárcel M. Serotipos y resistencia antimicrobiana de aislamientos meníngeos de Streptococcus pneumoniae. Cuba, 2007-2012. Vacci Monitor. 2014;23(3):117-23.
European Respiratory Society. Acute lower respiratory infections. In: European Lung White Book [homepage en Internet]; ERS 2016 [citado 20 de Octubre de 2016]. Disponible en: http://www.erswhitebook.org/chapters/acute-lower-respiratoryinfections
Backhaus E, Berg S, Andersson R, Ockborn G, Malmström P, Dahl M, et al. Epidemiology of invasive pneumococcal infections: manifestations, incidence and case fatality rate correlated to age, gender and risk factors. BMC Infectious Diseases. 2016;16:367.