Navarro-Meza MC, González-Baltazar R, Muñoz-Lozano R, Alcantar-Flores F, Carmona-Navarro DE

Language: Spanish
References: 19
Page: 140-145
PDF size: 564.98 Kb.

ABSTRACT

Introduction. Genotypes of human papillomavirus (HPV) viruses that infect the genital areas can infect the mouth and this entity is known as "oral HPV". The contagious methods described are the sexual route, the contact with contaminated liquids or surgical material, the exposure to vaporization smoke of condylomatous lesions and the immunosuppression. The medical staff has an implicit risk in their daily practice, so the objective of the present study was to diagnose and identify human papillomavirus genotypes in the oral cavity of medical personnel.
Material and Methods. This is a cross-sectional study employing aleatory sampling using substitution with a total amount of 176 physicians from various specialties. Personal data, age, sex, working area, smoking, alcohol consumption and sexual habits were recorded along with an oral cavity inspection and biopsy. HPV genotyping was done to every biopsy using polymerase chain reaction (PCR).
Results. 176 members of the medical staff were evaluated, identifying oral mucsa changes (acetowhite) in 15.9% (n=28). Identified anatomic sites were: tongue in 14.7% (n= 26), uvula 0.5% (n=28) and trigone 0.5% (n=1). Afterwards, patients underwent biopsy with visual inspection of acetowhite positive areas. Inflammation was found in 11.93% (n=21), hyperplasia in 2.27% (n=4) and histopathologic changes compatible with HPV infection in 1.7% (n=3). PCR genotyping of the lesions was positive for HPV-6.
Discussion. HPV oral infections in the population studied is high and with multifactor risks.

REFERENCES

1. 1.Cháirez-Atienzo P, Vega-Memíje ME, Zambrano- Galván G, García-Calderón AG, Maya-García IA, Cuevas-González JC. Presencia del Virus Papiloma H uman o en la Cavidad Oral : Revisión y Actualización de la Literatura. International journal of odontostomatology, 2015;9(2):233-238.

2. 2.Golusinski P. Risk Factors for Oral Infection with Human Papillomavirus. Cancer Res. 2017;206:73- 85.

3. 3.Estrada-Pereira GA, Márquez-Filiu M, González- Heredia E. Infección por papilomavirus humano en pacientes con liquen plano bucal. MEDISAN. 2013;17(5): 784-791.

4. 4.Dayyani F, Etzel CJ, Liu M, Ho CH, Lippman SM, Tsao AS. Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol. 2010;2:15.

5. 5.IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC monographs on the evaluation of carcinogenic risks to humans: IARC monographs, volume 100B. A review of human carcinogens. B. Biological agents. Lyon: International Agency for Research on Cancer; 2012;280- 278.

6. 6.Bouda M, Gorgoulis VG, Kastrinakis NG, Giannoudis A, Tsoli E, Danassi-Afentaki D, et al. "High risk" HPV types are frequently detected in potentially malignant and malignant oral lesions, but notinnormaloralmu c o s a . Mod Pathol. 2000;13:644–653.

7. 7.Kojima A, Maeda H, Sugita Y, Tanaka S, Kameyama Y. Human papillomavirus type 38 infection in oral squamous cell carcinomas. Oral Oncol. 2002;38:591–596.

8. 8.Kim KS, Park SA, Ko KN, Yi S, Cho YJ. Current status of human papillomavirus vaccines. Clin Exp Vaccine Res. 2014;3:168–175.

9. 9.Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008;100:261–269.

10. 10.L.M. Myriam, M. Marcelo, A.M. Luis . Valoración diagnóstica de técnicas moleculares para detección de infección bucal por virus del papiloma humano. Enf Inf Microbiol. 2012;32 (1):25–30.

11. 11.Jimenez C., Correnti M, Salma N, Cavazza M, Perrone M. Detección del virus papiloma humano en entidades clínicas benignas de la cavidad bucal, mediante la reacción en cadena de la polimerasa e hibridación molecular. Acta Odontológica Venezolana. 2001;39 (2);10–15.

12. 12.Gonzalez-Losa MR, Barrera ES, Herrera-Pech V, Conde-Ferráez L, Puerto-Solís M, Ayora-Talavera G. (2015). Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico. Brazilian Journal of Microbiology. 2015;46(1):301-306.

13. 13.Agrawal GP, Joshi PS, Agrawal A. Role of HPV-16 in pathogenesis of oral epithelial dysplasia and oral squamous cell carcinoma and correlation of p16ink4a expression in HPV-16 positive cases: An immunohistochemical study. I. S. R. N. Pathol. 2013;(2013):1-8.

14. 14.Álvarez Aldana A, Sepúlveda Arias JC, Siller López F. Carcinogénesis inducida por el virus del papiloma humano. Investig. Andin. 2012;14(24):438-56.

15. 15.Badaracco G, Venuti A, Di Lonardo A, Scambia G, Mozetti S, Benedetti Pacini P, Mansuco S, Marcante ML. Concurrent HPV infection in oral and genital mucosa. J Oral Pathol Med. 1998;27:130-134

16. 16.Anaya Flores y cols. Nivel de conocimiento de los trabajadores de la salud sobre infecciones nosocomiales y su prevención. Enf Inf Microbiol. 2009;29(1):20-28.

17. 17.Limongi L, Pérez C, Jiménez C. Prevalencia de la infección por virus papiloma humano en la cavidad bucal en pacientes pediátricos. Acta Odontol Venez. 2006;44:277-83.

18. 18.Ha PK, Califano JA. The role of human papillomavirus in oral carcinogenesis. Critical Review sin Oral Biolog y and Medicine. 2004;15(4):188–196.

19. 19.Greer RO, Schroeder KL, Crosby L. Morphologic and immunohistochemical evidence of human papillomavirus capsid antigen in smokeless tobacco keratoses from juveniles and adults. Journal of Oral and Maxillofacial Surgery. 1988;46(11):919–929.