2018, Number 1
<< Back Next >>
Med Int Mex 2018; 34 (1)
Clinical and sociodemographic characteristics of patients with diabetes mellitus type 1 in a University Hospital of Colombia
Palmezano-Díaz JM, Figueroa-Pineda CL, Rodríguez R, Plazas-Rey L, Corredor-Guzmán K, Pradilla-Suárez LP, Cristancho-Vásquez SM, Coha-Díaz JP
Language: Spanish
References: 31
Page: 46-56
PDF size: 319.22 Kb.
ABSTRACT
Background: Diabetes mellitus type 1 is an autoimmune disease caused by the interaction of multiple environmental and genetic factors leading to the autoimmune destruction of pancreatic B cells producers of insulin. The incidence and prevalence of diabetes mellitus type 1 vary considerably all around the world.
Objective: To establish the clinical and socio-demographic characteristics of diabetes mellitus type 1.
Material and Method: A descriptive, cross-sectional and retrospective study that included patients with diabetes type 1 who entered to a university hospital of Colombia from 2012 to 2016. Then, a statistical analysis was done according to variables.
Results: Intrahospitalary prevalence of diabetes mellitus type 1 was of 19 cases for each 100,000 patients older tan 13 years. It was more frequent in women with 61.3%; the mean age at diagnosis was of 14.89 years. Diagnosis was established in a clinical manner without autoimmunity studies, they were patients with not-controlled disease with a mean HbA1c of 11.5%; the frequent complications were: diabetic cetoacidosis with 46.6%, as well as hypoglycemia. The most frequently prescribed insulin in these patients was glargine, glulisine and regular insulin.
Conclusions: The findings suggest that some characteristics of diabetes mellitus 1 could be similar and some different to that reported in other studies; however, some possible investigations may be considered taking these results as basement.
REFERENCES
Zullo A, Sommese L, Nicoletti G, Donatelli F, et al. Epigenetics and type 1 diabetes: mechanisms and translational applications. J Laboratory Clin Med 2017;185:85-93.
Duvnjak L, Blaslov K, Vučić M, Knežević J. Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes. Diabetes Res Clin Pract 2016;121:119-126.
Tomer Y, Dolan LM, Kahaly G, Divers J, et al. Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. J Autoimmun 2015;60:32-39.
Watad A, Azrielant S, Bragazzi NL, Sharif K, et al. Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity. J Autoimmun 2017;1-18.
Fang C, Huang Y, Pei Y, Zhang HH, et al. Genome-wide gene expression profiling reveals that CD274 is up-regulated new-onset type 1 diabetes mellitus. Acta Diabetol 2017. doi:10.1007/s00592-017-1005-y
Huxley RR, Peters SAE, Mishra GD, Woodward M. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and metaanalysis. Lancet Diabetes Endocrinol 2015;3:198-206.
Kahaly GJ, Hansen MP. Type 1 diabetes associated autoimmunity. Autoimmunity Rev 2016;15:644-648.
Ziegler AG, Danne T, Dunger DB, Berner R, et al. Primary prevention of beta-cell autoimmunity and type 1 diabetes e The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives. Mol Metab 2016;5(4):255-262.
Atkinson M. The pathogenesis and natural history of type 1 diabetes. Cold Spring Harb Perspect Med 2012;2(11).
Insel RA, Dunne JL, Atkinson MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 2015;38:1964-1974.
Awadalla NJ, Hegazy AA, Abd M, Elhady M. Environmental factors associated with type 1 diabetes development: A case control study in Egypt. Int J Environ Res Public Health 2017;14(6)615.
Dabelea D, Mayer-Davis EJ, Saydah S, et al.; SEARCH for Diabetes in Youth Study. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 2014;311:1778-1786.
Pinhas-Hamiel O, Hamiel U, Levy-Shraga Y. Eating disorders in adolescents with type 1 diabetes: challenges in diagnosis and treatment. World J Diabetes 2015;6:517-526.
Martyn-Nemeth P, Quinn L, Hacker E, Park H, Kujath AS. Diabetes distress may adversely affect the eating styles of women with type 1 diabetes. Acta Diabetol 2014;51:683-686.
Aschner P. Epidemiología de la diabetes en Colombia. Av Diabetol 2010;26:95-100.
Mendioroz L, Sanz I. Enfermedades autoinmunes sistémicas en atención primaria FMC 2016;23(9):513-527.
Kakleas K, Soldatou A, Karachaliou F, Karavanaki K. Associated autoimmunity in children and adolescents with type 1 3 diabetes mellitus (T1DM). Autoimmunity Reviews 2015;14(9):781-797.
Corwell B, et al. Current diagnosis and treatment of hyperglycemic emergencies. Emerg Med Clin North Am 2014;32(2):437-52.
Maletkovic J, Drexler A. Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Endocrinol Metab Clin North Am 2013;42(4):677-95.
Powers MA, Bardsley J, Cypress M, et al. Diabetes self-management education and support in type 2 diabetes: a joint position statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics. Diabetes Care 2015;38:1372-1382.
Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, et al. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 2000;23:1516-26.
Pollak CF, Vásquez AT. Diabetes autoinmune (latente) del adulto. Rev Med Chile 2012;140:1476-1481.
Mayer EJ, Lawrence JM, Dabelea D, Divers J, et al. Incidence trends of type 1 and type 2 diabetes among youths, 2002- 2012. N Engl J Med 2017;376(15):1419-1429.
Ahmad MA, Hempe JM, Velasco C, Gomez R, Vargas A, Chalew S. Differences in red blood cell indices do not explain racial disparity in hemoglobin A1c in children with type 1 diabetes. J Pediatrics 2016;176:197-199.
Alonso GT, Pyle L, Frohnert. Change in hemoglobin A1c one year following the 2014 American Diabetes Association guideline update. Diabetes Research and Clinical Practice 2017;129:169-172.
Ryan EA, Holland J, Stroulia E, Bazelli B, et al. Improved A1C levels in type 1 diabetes with smartphone app use. Can J Diabetes 2017;41(1):33-40.
Standards of Medical Care in Diabetes 2017. Diabetes Care 2017;40(Suppl. 1):S4-S5.
Chen YL, Qiao YC, Song XN, Ling W, et al. Emotional exhaustion-induced latent autoimmune diabetes in adults in a young lady: A CARE-compliant case report. Medicine (Baltimore) 2017;96:20.
Guisado P, Cano M, Carrasco M, Corres J, Matei AM, González O. Clinical features, mortality, hospital admission, and length of stay of a cohort of adult patients with diabetic ketoacidosis attending the emergency room of a tertiary hospital in Spain. Endocrinol Nutr 2015;62(6):277-284.
Gómez N, García MG, Fonseca I, Gómez CO, Gómez IA, Villalobos L. Cetoacidosis diabética en ninos: experiencia hospitalaria. Estudio retrospectivo de 15 años. Bol Med Hosp Infant Mex 2015;72(5):313-317.
Fayfman M, Pasquel FJ, Umpierrez GE. Management of hyperglycemic crises: Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Med Clin North Am 2017;101(3):587-606.