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ISSN 1729-6935 (Electronic)
16 de abril

2017, Number 264

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16 de abril 2017; 56 (264)

Hypothermia as therapeutic alternative

Guillén-Garcia BG, Pérez-Saad H

Language: Spanish
References: 43
Page: 64-72
PDF size: 775.14 Kb.


ABSTRACT

Therapeutic hypothermia is defined as a reduction of core body temperature for a certain period of time and it is aimed at reducing the injuries associated with arterial blood deficit in the nervous system.This work contains the mechanisms of cellular damage induced by ischemia and also the biochemical pathways targeted by hypothermia effects. 43 articles indexed in PubMed were reviewed. The objectives of this work are directed to describe the beneficial effects of therapeutic hypothermia in the context of cellular respiration affected by the ischemic event, and also describe, from a molecular point of view, the neuroprotective effect of hypothermia. Understanding the elements associated with the benefit of therapeutic hypothermia can integrate knowledge of basic sciences with clinical situations and therefore contributes to encourage meaningful learning in medical students.


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