Guillén-Garcia BG, Pérez-Saad H

Idioma: Español
Referencias bibliográficas: 43
Paginas: 64-72
Archivo PDF: 775.14 Kb.

RESUMEN

La hipotermia terapéuticaconsiste en mantener una temperatura corporal específica por un período determinado y está dirigida a reducir las secuelas de laisquemiaen el sistema nervioso.En este trabajo se exponen los mecanismos del daño celular inducido por la isquemia y se describenlos procesos bioquímicos en los que incide el efecto de la hipotermia.Se revisaron 43 artículos indexados en PubMed.Los objetivos de este trabajo se dirigen adescribir los efectos beneficiosos de la hipotermia terapéutica en el contexto de la respiración celular afectada por el evento isquémico, y a describir, desde un punto de vista molecular, el efecto neuroprotector de la hipotermia. La comprensión de los elementos asociados al beneficio de la hipotermia terapéutica permite integrar conocimientos de las ciencias básicas con situaciones clínicas y contribuye a incentivar el aprendizaje significativo en estudiantes de medicina.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Alzaga AG, Cerdan M, Varon J. Therapeutic hypothermia. Resuscitation. 2006;70(3):369-80.

2. Zeiner A, Holzer M, Sterz F, Behringer W, Schorkhuber W, Mullner M, et al. Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. A clinical feasibility trial. Hypothermia After Cardiac Arrest (HACA) Study Group. Stroke. 2000;31(1):86-94.

3. Henderson AR. Cold-man's assiduous remedy. Med Ann Dist Columbia. 1971;40(9):583-8.

4. Patel JK, Parikh PB. Association between therapeutic hypothermia and long-term quality of life in survivors of cardiac arrest: A systematic review. Resuscitation. 2016;103:54-9.

5. Dunkley S, McLeod A. Therapeutic hypothermia in patients following traumatic brain injury: a systematic review. Nurs Crit Care. 2017;22(3):150-60.

6. Sidhu SS, Schulman SP, McEvoy JW. Therapeutic Hypothermia After Cardiac Arrest. Curr Treat Options Cardiovasc Med. 2016;18(5):30.

7. Han Z, Liu X, Luo Y, Ji X. Therapeutic hypothermia for stroke: Where to go? Exp Neurol. 2015;272:67-77.

8. Ji Z, Liu K, Cai L, Peng C, Xin R, Gao Z, et al. Therapeutic effect of tPA in ischemic stroke is enhanced by its combination with normobaric oxygen and hypothermia or ethanol. Brain Res. 2015;1627:31-40.

9. Kuramatsu JB, Kollmar R, Gerner ST, Madzar D, Pisarcikova A, Staykov D, et al. Is Hypothermia Helpful in Severe Subarachnoid Hemorrhage? An Exploratory Study on Macro Vascular Spasm, Delayed Cerebral Infarction and Functional Outcome after Prolonged Hypothermia. Cerebrovasc Dis. 2015;40(5-6):228-35.

10. Castillo L, Bugedo G, Rovegno M. Therapeutic hypothermia as a bridge to transplantation in patients with fulminant hepatic failure. Rev Bras Ter Intensiva. 2015;27(1):72-6.

11. Galvao TF, Silva MT, Marques MC, de Oliveira ND, Pereira MG. Hypothermia for perinatal brain hypoxia-ischemia in different resource settings: a systematic review. J Trop Pediatr. 2013;59(6):453-9.

12. Kali GT, Martinez-Biarge M, Van ZJ, Smith J, Rutherford M. Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy had favourable outcomes at a referral hospital in a middle-income country. Acta Paediatr. 2016;105(7):806-15.

13. Zgavc T, Ceulemans AG, Sarre S, Michotte Y, Hachimi-Idrissi S. Experimental and clinical use of therapeutic hypothermia for ischemic stroke: opportunities and limitations. Stroke Res Treat. 2011;2011:689290.

14. Hemmen TM, Lyden PD. Induced Hypothermia for Acute Stroke. Stroke. 2007;38(2):794-9.

15. Zandt BJ, Stigen T, Ten HB, Netoff T, van Putten MJ. Single neuron dynamics during experimentally induced anoxic depolarization. J Neurophysiol. 2013;110(7):1469-75.

16. Shuaib A, Hussain MS. The past and future of neuroprotection in cerebral ischaemic stroke. Eur Neurol. 2008;59(1-2):4-14.

17. Fisher M. The ischemic penumbra: identification, evolution and treatment concepts. Cerebrovasc Dis. 2004;17 Suppl 1:1- 6.

18. Demyanenko SV, Panchenko SN, Uzdensky AB. Expression of neuronal and signaling proteins in penumbra around a photothrombotic infarction core in rat cerebral cortex. Biochemistry (Mosc ). 2015;80(6):790-9.

19. Woodruff TM, Thundyil J, Tang SC, Sobey CG, Taylor SM, Arumugam TV. Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener. 2011;6(1):11-29.

20. Dirnagl U. Pathobiology of injury after stroke: the neurovascular unit and beyond. Ann N Y Acad Sci. 2012;1268:21-5.

21. Posada-Duque RA, Barreto GE, Cardona-Gomez GP. Protection after stroke: cellular effectors of neurovascular unit integrity. Front Cell Neurosci. 2014;8:231.

22. Godinez-Rubi M, Rojas-Mayorquin AE, Ortuno-Sahagun D. Nitric oxide donors as neuroprotective agents after an ischemic stroke-related inflammatory reaction. Oxid Med Cell Longev. 2013;2013:297357.

23. Lo EH, Dalkara T, Moskowitz MA. Mechanisms, Challenges and Opportunities in Stroke. Nature Reviews Neuroscience. 2003;4:399-415.

24. Sims NR, Muyderman H. Mitochondria, oxidative metabolism and cell death in stroke. Biochim Biophys Acta. 2010;1802(1):80-91.

25. Green AR, Shuaib A. Therapeutic strategies for the treatment of stroke. Drug Discov Today. 2006;11(15-16):681-93.

26. Cavallucci V, D'Amelio M. Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases. Curr Pharm Des. 2011;17(3):215-29.

27. Cho S, Liu D, Gonzales C, Zaleska MM, Wood A. Temporal assessment of caspase activation in experimental models of focal and global ischemia. Brain Research. 2003;982:146-55.

28. Zhao H, Shimohata T, Wang JQ, Sun G, Schaal DW, Sapolsky RM, et al. Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J Neurosci. 2005;25(42):9794-806.

29. Macrez R, Ali C, Toutirais O, Le MB, Defer G, Dirnagl U, et al. Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol. 2011;10(5):471-80.

30. Xiong XY, Liu L, Yang QW. Functions and Mechanisms of Microglia/Macrophages in Neuroinflammation and Neurogenesis during Stroke. Prog Neurobiol. 2016 May 7.

31. Al-Bahrani A, Taha S, Shaath H, Bakhiet M. TNF-alpha and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents. Curr Neurovasc Res. 2007;4(1):31-7.

32. Castillo J, Rodríguez I. Biochemical Changes and Inflammatory Response as Markers for Brain Ischaemia: Molecular Markers of Diagnostic Utility and Prognosis in Human Clinical Practice. Cerebrovascular Diseases. 2004;17(suppl 1):7-18.

33. van der Worp HB, Macleod MR, Bath PM, Demotes J, Durand- Zaleski I, Gebhardt B, et al. EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke. Int J Stroke. 2014;9(5):642-5.

34. Wang H, Wang B, Normoyle KP, Jackson K, Spitler K, Sharrock MF, et al. Brain temperature and its fundamental properties: a review for clinical neuroscientists. Front Neurosci. 2014;8:307.

35. Yenari MA, Han HS. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci. 2012;13(4):267-78.

36. Varon J, Marik PE, Einav S. Therapeutic hypothermia: a stateof- the-art emergency medicine perspective. Am J Emerg Med. 2012;30(5):800-10.

37. Soto-Ruiz KM, Varon J. Resuscitation great. George W. Crile: a visionary mind in resuscitation. Resuscitation. 2009;80(1):6-8.

38. Zgavc T, De GD, Ceulemans AG, Stoop W, Hachimi-Idrissi S, Michotte Y, et al. Mild hypothermia reduces activated caspase-3 up to 1 week after a focal cerebral ischemia induced by endothelin-1 in rats. Brain Res. 2013;1501:81-8.

39. Zhao H, Yenari MA, Cheng D, Sapolsky RM, Steinberg GK. Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia. J Cereb Blood Flow Metab. 2005;25(9):1119-29.

40. Jia G, Wang Q, Wang R, Deng D, Xue L, Shao N, et al. Tubeimoside-1 induces glioma apoptosis through regulation of Bax/Bcl-2 and the ROS/Cytochrome C/Caspase-3 pathway. Onco Targets Ther. 2015;8:303-11.

41. Bi Y, Huan Y, Cai W, Wang X, Liang Z, Liu Z, et al. Mild hypothermia in combination with minimally invasive evacuation of hematoma reduces inflammatory damage in patients via the nuclear factor-kappaB pathway. Exp Ther Med. 2014;8(6):1717-22.

42. Bisschops L, van der Hoeven JG, Mollnes TE, Hoedemaekers C. Seventy-two hours of mild hypothermia after cardiac arrest is associated with a lowered inflammatory response during rewarming in a prospective observational study. Crit Care. 2014;18(5):546.

43. Dietrich WD, Bramlett HM. The evidence for hypothermia as a neuroprotectant in traumatic brain injury. Neurotherapeutics. 2010;7(1):43-50.