2017, Number 2
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Arch Neurocien 2017; 22 (2)
Rosmarinus officinallis improves learning and memory of mouse model of Morris water maze
Barón FTV, Hernández LD, Pérez GML, Delgadillo GHJ, Ríos CC
Language: Spanish
References: 22
Page: 6-12
PDF size: 463.92 Kb.
ABSTRACT
Rosmarinus officinalis known as rosemary oil is used in herbal medicine, recent
studies have found that some alkaloids act as antidepressants and anti-inflammatories
because of their inhibitory activity on acetylcholinesterase and butyrylcholinesterase,
so that rosemary could be a complementary treatment for the disease. Alzheimer's
disease, because this disease is linked to an acetylcholine deficiency.
Objective: to evaluate the effect of rosemary oil on learning through the Morris water
maze.
Material: twenty-four male CD1 mice weighing 20-30g were divided into four groups:
1. saline solution intraperitoneally 2. memantine (10µg/kg) intraperitoneally, 3.
rosemary oil (20µg/kg) inhalation and 4.rosemary oil (120µg/Kg) oral administration.
The time that remained in each quadrant was measured as a way of evaluating
learning, through the recognition of the area.
Results: It was found that the group treated with oral rosemary oil had a learning
similar to that of memantine, a drug used to treat Alzheimer's, in which the group
treated by inhalation was not significant.
Conclusions: The present study showed that mice treated with oral rosemary oil did
exhibit a tendency to improve performance in the Morris water maze compared to
mice treated by inhalation, indicating that improved learning and memory capacity, is
the beginning for complementary treatments in Alzheimer's disease and other types
of dementia using rosemary oil.
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