2005, Number 3
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Cir Plast 2005; 15 (3)
Hypocholesterolemia and clinical outcome in severely burned patients
Papadópulos CAA, Gutiérrez SE, Duffy VBE, Fernández SG, Portal CC, Pérez PF
Language: Spanish
References: 29
Page: 140-144
PDF size: 65.74 Kb.
ABSTRACT
The clinical implications of hypolipidemia were studied. Low blood concentration of lipids and lipoproteins has been related to a poor prognosis in a variety of critical illnesses. The purpose of this study was to determine the relationship between hypolipidemia and the clinical outcome in severely burned patients. Twenty four patients with second and third degree burns involving more than 30% of total body surface (TBS) and airway involvement that required mechanical assisted ventilation admitted between March 2003 and December 2004 were included. Serum lipids (cholesterol and triglycerides) were determined 24 hours after the time of injury. The following criteria were evaluated: death, subsequent infection, length of stay, and magnitude of organ dysfunction (APACHE II score). Mean total body surface involvement (TBS) was 53.6 ± 21.5, and mean APACHE II score was 28.6 ± 6.0. Cholesterol serum concentration was low: 91.6 ± 41.19 mg/dL. Mortality was 50% (twelve patients) and the mean cholesterol serum concentration in this group was 73.7 ± 34.7 mg/dL. Patients who survived had a mean cholesterol serum concentration significantly higher, p = 0.003 (109.6 ± 40.5 mg/dL), than those who died. In the case of triglycerides concentrations: 124.7 ± 67 mg/dL in the group of patients who died and 195.2 ± 77 in the group of patients who survived, reaching a statistically significant difference of p = 0.02. Mean values of TBS and APACHE II were significantly higher in the group of patients who died, p = 0.03 and p = 0.001 respectively. We concluded that severely burned patients have lipid alterations. Hypolipidemia in critically burned patients correlates with a higher mortality risk.
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