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ISSN 2992-8559 (Electronic)
ISSN 1405-0625 (Print)

2017, Number 3

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Cir Plast 2017; 27 (3)

Botulinum toxin type A is associated with an increase in angiogenesis of wounds in an experimental murine model

Carrillo-Córdova JR, Martínez-Wagner R, Trolle-Silva AM, Bracho-Olvera H, Carrillo-Córdova DM, Carrillo-Córdova LD

Language: Spanish
References: 24
Page: 107-112
PDF size: 264.87 Kb.


ABSTRACT

Healing is a natural process that restores tissue integrity after injury. Botulinum toxin type A (BTT-A) has shown to increase angiogenesis in flap models. The aim of this research was to study the effect of BTT-A during wound healing. We studied 19 mice distributed in four groups depending on the day they were sacrificed (six on day 3, four on day 6, five on day 9, and four on day 12). Two wounds were made on the back of the mice. In one wound BTT-A (2.5 IU) was infiltrated while 0.9% saline solution was infiltrated the other wound; both infiltrations were in the subcutaneous cellular tissue. An evaluation of angiogenesis was performed on each group. Statistical analysis was performed using Student’s t-test and the results were established as significant with p ≤ 0.05. Angiogenesis was greater in the experimental area. On day 3 the wound with botulinum toxin had less angiogenesis (5.1 versus 13.5 [CI: 4.7-11.9] p = 0.001), on day 6 and 9, no significant differences were found between both groups; finally, on day 12, in the wound with botulinum toxin a greater amount of angiogenesis was identified (8.6 versus 4.9 [CI: -5.3 - -2.09] p = 0.002). Botulinum toxin type A modulates the healing process of wounds by increasing the formation of blood vessels throughout the process.


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