2017, Number 3
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Sal Jal 2017; 4 (3)
El cáncer de próstata y un virus oncolítico como alternativa de tratamiento
Gutiérrez-Ortega RC, Sánchez-Soto JE, Gaona-Bernal J, Absalón-Constantino AE, Herrera-Rodríguez SE
Language: Spanish
References: 30
Page: 192-200
PDF size: 602.38 Kb.
ABSTRACT
Prostate cancer is the most common type of cancer found
in males. More than 65% of prostate cancer cases are
diagnosed in men over the age of 65, been this disease
among the leading causes of death. Although this disease
can be prevented or detected in early stages through
annual exams such as: prostate specifi c antigen study, rectal
examination and ultrasound. At date, the treatment for this
type of cancer continues to be invasive and with multiple
adverse eff ects such as: fatigue, hair loss, nausea, loss of
appetite and consequently body weight. In recent years,
research into cancer treatment has focused on making
it more specific, sensitive and eff ective that has fewer
adverse eff ects. In these sense, viruses have been used as an
alternative to treat some types of cancer. In which oncolytic
virotherapy based in virus has the characteristic by the
specifi cally infection of tumor cell naturally or because of
the adaptation of the virus to propagate in human tumor
cells. In addition, these oncolytic viruses can be modified
by genetic engineering to improve their oncolytic capacity
and/or its selectivity for some cellular target. Th is review
focus on the Newcastle virus disease and its potential in
oncolytic virotherapy for treatment of prostate cancer,
and to mention some genetic modifi cations that have
been made to increase, monitor and evaluate its oncolytic
activity.
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