2017, Number 3
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Rev Hematol Mex 2017; 18 (3)
Invasive rhinosinusal mucormycosis after hematopoietic stem cell transplantation in a myelodysplastic syndrome patient
Gastélum-Cano JM, Motolinia-Muñoz Y, Marín-Corte JC, Ortega-Amaya ER, Gordillo-Martínez AM, Ruiz-Argüelles GJ
Language: English
References: 13
Page: 134-138
PDF size: 291.67 Kb.
ABSTRACT
Mucormycosis is a pathologic entity, caused for molds belonging to
mucorales order; among risk factors are hematological malignancies,
hematopoietic stem cell transplantation (HSCT) and treatment with
corticosteroids. This article reports the case of a 56-year-old male
patient, Mexican mestizo, with type 2 diabetes mellitus (T2DM)
and class 2 obesity (BMI 37.38). As a result of pancytopenia, the
bone marrow studies disclosed myeloid hyperplasia and features of
myelodysplasia. An outpatient allogeneic hematopoietic stem cell
transplantation (Allo-HSCT) was performed on January 14th, 2015.
After engrafting successfully, on day + 250 pancytopenia due to graft
loss ensued. Then, a second outpatient allo-HSCT was made, achieving
100% chimerism. During the aplastic phase, patient developed a
rhinosinusal lesion in which the causal agent was identified as Mucor
sp. It is important to consider HSCT secondary mucormycosis as a risk
factor in hematological malignancies patients.
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