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2002, Number 6

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Gac Med Mex 2002; 138 (6)

Pancreatic Β-cell neogenesis and regeneration.

Haro-Hernández R, Méndez JD

Language: Spanish
References: 73
Page: 557-564
PDF size: 52.46 Kb.


ABSTRACT

Objective: To review the literature on Β-cell neogenesis and regeneration, with special interest in substances that regulate such processes. Design: Representative papers were selected through a computer MEDLINE search from 1990 to 2000. Results: Several studies showed that once islets of Langerhans developed from small pancreatic ducts, this process did not continue in normal adult individuals. However, it has been published that new Β-cell formation can occur in vivo in certain experimental models through neogenesis, in which gene pax 4 is extremely important. On the other hand, substances that stimulate the regenerative process of Β-cells include glucose, several hormones and certain growth factors. Conclusions: Substances that stimulate the regenerative process commonly express this effect in elevated, non-physiologic concentrations; thus, their possible therapeutic importance is not yet clear. Nevertheless, the Reg protein, present in regenerative pancreas and implied in neogenesis process, has actual possibilities of becoming therapeutically important.


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