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ISSN 0016-3813 (Impreso)

2002, Número 6

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Gac Med Mex 2002; 138 (6)


Neogénesis y regeneración de las células Β pancreáticas

Haro-Hernández R, Méndez JD

Idioma: Español
Referencias bibliográficas: 73
Paginas: 557-564
Archivo PDF: 52.46 Kb.


RESUMEN

Objetivo: Revisar la literatura biomédica acerca de la neogénesis y regeneración de las células Β pancreáticas con énfasis en la regulación de estos procesos. Diseño: Se localizaron los artículos más relevantes sobre el tema mediante una búsqueda en la base de datos MEDLINE que comprendió de 1990 a 2000. Resultados: Los datos reportados en la literatura demuestran que la diferenciación de los islotes de Langerhans a partir de conductos pancreáticos pequeños durante la formación del páncreas, en condiciones normales no continúa. Sin embargo, se ha determinado que en ciertos modelos experimentales in vivo la formación de nuevas células Β puede ocurrir por neogénesis, para esto es muy importante la expresión del gen Pax 4. El proceso de regeneración de células Β es inducido por varias sustancias, entre ellas glucosa, varias hormonas y ciertos factores de crecimiento. Conclusiones: Los mejores resultados observados con las sustancias que estimulan el proceso de regeneración de las células Β se han obtenido empleando concentraciones que rebasan los niveles fisiológicos, por lo que su posible importancia terapéutica no es muy clara. Sin embargo, existen posibilidades reales de que la proteína Reg pudiera, en el futuro, tener aplicación clínica.


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