Hernández JJ, Gallegos B, Pérez CME, Pérez CE, Pina S, Hernández CP

Language: Spanish
References: 33
Page: 55-64
PDF size: 424.09 Kb.

ABSTRACT

Platelets are essential components in clot formation mainly at sites of vascular damage, but also in the development of thrombi, in the absence of vascular damage. It has been suggested that platelets from diabetic patients are hyperactive and contribute to the occurrence of severe complications of the disease, such as acute myocardial infarction and stroke. Hyperglycemia is only one factor in DM associated with platelet hyperactivity, however, the mechanisms that induce these effects are not completely understood. This review will address the mechanisms that relate hyperglycemia with increased platelet activation, as well as and the role of glycosylation on the platelet activation.

REFERENCES

1. Santilli F, Simeone P, Liani R, Davi G (2015) Platelets and diabetes mellitus. Prostaglandins Other Lipid Mediat 120:28-39.

2. Makino A, Dai A, Han Y, Youssef KD, Wang W, Donthamsetty R, Scott BT, Wang H, Dillmann WH (2015) O-GlcNAcase overexpression reverses coronary endothelial cell dysfunction in type 1 diabetic mice. Am J Physiol Cell Physiol 309:C593-9.

3. Blair P, Flaumenhaft R (2009) Platelet alpha granules: basic biology and clinical correlates. Blood Rev 23:177-89.

4. Semple W, Italiano JE, Freedman J (2011) Platelets and the immune continuum. Nat Rev Immunol 11:264–74.

5. Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC (2009) Platelet functions beyond hemostasis. J Thromb Haemost 7:1759–66.

6. Li Z, Delaney MK, O´Brien KA, Du X (2010) Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol 30:2341-9.

7. Estevez B, Du X (2017) New concepts and mechanisms of platelet activation signaling. Physiology (Bethesda) 32:162-177.

8. Kubisz P, Stanciakova L, Stasko J, Galajda P, Mokan M (2015) Endothelial and platelet markers in diabetes mellitus type 2. World J Diabetes 6:423-31.

9. Lippi G, Salvagno GL, Nouvenne A, Meschi T, Borghi L, Targher G (2015) The mean platelet volume is significantly associated with higher glycated hemoglobin in a large population of unselected outpatients. Prim Care Diabetes 9:226-30.

10. Verdoia M, Schaffer A, Barbieri L, Cassetti E, Nardin M, Bellomo G, Marino P, Sinigaglia F, De Luca G; Novara Artherosclerosis Study (NAS) group (2014) Diabetes, glucose control and mean platelet volume: a single-centre cohort study. Diabetes Res Clin Pract 104:288-94.

11. Keating FK, Sobel BE, Schneider DJ (2003) Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus. Am J Cardiol 92:1362-5.

12. Sudic D, Razmara M, Forslund M, Ji Q, Hjemdahl P, Li N (2006) High glucose levels enhance platelet activation: involvement of multiple mechanisms. Br J Haematol 133:315-22.

13. Gresele P, Guglielmini G, De Angelis M, Ciferri S, Ciofetta M, Falcinelli E, Lalli C, Ciabattoni G, Davì G, Bolli GB (2003) Acute, short-term hyperglycemia enhances shear stress-induced platelet activation in patient with type II diabetes mellitus. J Am Coll Cardiol 41:1013- 20.

14. Liu D, Maier A, Scholze A, Rauch U, Boltzen U, Zhao Z, Zhu Z, Tepel M (2008) High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway. Arterioscler Thromb Vasc Biol 28:746-51.

15. Yamagishi SI, Edelstein D, Du XL, Brownlee M (2001) Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction. Diabetes 50:1491-4.

16. Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Long-term untretated streptozotocin-diabetes leads to increased e x p r e s s i o n a n d e l e va t e d a c t i v i t y o f prostaglandin H2 synthase in blood platelets. Platelets 27:203-11.

17. Carnevale R, Iuliano L, Nocella C, Bartimoccia S, Trape S, Russo R, Gentile MC, Cangemi R, Loffredo L, Pignatelli P, Violi F; IPINET Group (2013) Relationship between platelet and urinary 8-Iso-PGF2α levels in subjects with different degrees of NOX2 regulation. J Am Heart Assoc 2:e000198.

18. Minuz P, Andrioli G, Degan M, Gaino S, Ortolani R, Tommasoli R, Zuliani V, Lechi A, Lechi C (1998) The F2-isoprostane 8 -epiprostaglandin F2α increases platelet adhesion and reduces the antiadhesive and antiaggregatory effects of NO. Arterioscler Thromb Vasc Biol 18:1248-56.

19. Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J (2011) Glucose and collagen regulate human platelet activity trough aldose reductase induction of thromboxane. J Clin Invest 121:4462-76.

20. Massucco P, Mattielo L, Russo I, Traversa M, Doronzo G, Anfossi G, Trovati M (2005) High glucose rapidly activates the nitric oxide/ cyclic nucleotide pathway in human platelets via an osmotic mechanism. Thromb Haemost 93:517-26.

21. Duan X, Zhan Q, Song B, Zeng S, Zhou J, Long Y (2014) Detection of platelet microRNA expression in patients with diabetes mellitus with or without ischemic stroke. J Diabetes Complications 28:705-10.

22. Yang S, Zhao J, Chen Y, Lei M (2016) Biomarkers associated with ischemic stroke in diabetes mellitus patients. Cardiovasc Toxicol 16:213-22.

23. Fejes Z, Póliska S, Czimmerer Z, Káplár M, Penyige A, Gál Szabó G, Beke Debreceni I, Kunapuli SP, Kappelmayer J, Nagy B Jr (2017) Hyperglycaemia suppresses micro RNA expression in platelets to increases P2RY12 and SELP levels in type 2 diabetes mellitus. Thromb Haemost 117:529-42.

24. Undas A, Wiek I, Stepien E, Zmudka K, Tracz W (2008) Hyperglycemia is associated with enhanced thrombin formation, platelet activation, and fibrin clot resistance to lysis in patients with acute coronary syndrome. Diabetes Care 31:1590-5.

25. Wang Y, Jobe SM, Ding X, Choo H, Archer DR, Mi R, Ju T, Cummings RD (2012) Platelet biogenesis and functions require correct protein O-glycosylation. Proc Natl Acad Sci USA 109:16143-8.

26. Bond MR, Hanover JA (2015) A little sugar goes a long way: the cell biology of O-GlcNAc. J Cell Biol 208:869-80.

27. Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, Poitout V (2012) Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol- 3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homebox-1. Proc Natl Acad Sci USA 109:2376-81.

28. Alejandro EU, Bozadjieva N, Kumusoglu D, Abdulhamid S, Levine H, Haataja L, Vadrevu S, Satin LS, Arvan P, Bernal-Mizrachi E (2015) Disruption of O-linked N-acetylglucosamine signaling induces ER stress and β cell failure. Cell Rep 13:2527-38.

29. D´Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G (2004) Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells. FASEB J 18:959-61.

30. Beleznai T, Bagi Z (2012) Activation of hexosamine pathway impairs nitric oxide (NO)-dependent arteriolar dilations by increased protein O-GlcNAcylation. Vasc Pharmacol 56: 115–21.

31. Federici M, Menghini R, Mauriello A, Hribal ML, Ferrelli F, Lauro D, Sbraccia P, Spagnoli LG, Sesti G, Lauro R (2002) Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells. Circulation 106:466-72.

32. Crawford GL, Hart GW, Whiteheart SW (2008) Murine platelets are not regulated by O-linked beta-N-acetylglucosamine. Arch Biochem Biophys 474:220-4.

33. Ferreira IA, Eybrechts KL, Mocking AI, Kroner C, Akkerman JW (2004) IRS-1 mediates inhibition of Ca2+ mobilization by insulin via the inhibitory G-protein Gi. J Biol Chem 279:3254-64.