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2017, Number 2

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Rev Educ Bioquimica 2017; 36 (2)

Las nanopartículas de plata: mecanismos de entrada, toxicidad y estrés oxidativo

Coutiño EMR, Ávila LL, Arroyo HO

Language: Spanish
References: 85
Page: 39-54
PDF size: 543.02 Kb.


ABSTRACT

In the last few decades, the study and application of colloids and nanoparticles (NPs) has spread notably in industry and particularly in medicine, developing the era of nanotechnology, with great relevance for its bioavailability and microbial effects. However, the inherent properties of NPs, especially those made from metals such as silver (AgNPs), have implications for the health of populations, which is evidenced when analyzing them from the perspective of their characteristics, among them, the Size, pathways of exposure, mechanisms of entry and, mainly, their effects on electron transport due to its affinity with ubiquinone, as well as the induction of oxidative stress, and its toxic effects (necrotic and apoptotic) and immunotoxic. Particularly, analyzing on the one hand the role of the main target of AgNPs, ubiquinone, in inducing oxidative stress markers such as hemo-oxygenase 1 and 8 isoprostanes, molecules involved with almost all chronic-degenerative diseases, And on the other the role of reducing ions on disulfide bonds and the destabilization of proteins.


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