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2002, Number 5

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Gac Med Mex 2002; 138 (5)

Mecanismos celulares y bioquímicos involucrados en la fisiopatogenia de la púrpura trombocitopénica autoinmune.

Domínguez-García MV, Rodríguez-Moyado H

Language: Spanish
References: 123
Page: 461-472
PDF size: 69.62 Kb.


ABSTRACT

Autoimmune thrombocytopenic purpura (ATP) is a bleeding disorder caused by excessive destruction of antibody-coated platelets. It is known that platelet destruction takes place in macrophages of reticulo-endotelial system, but immunological mechanisms involved in such destruction are unknown. The objective of this article is to review the literature concerning pathogenesis of ATP: to have controlled experimental conditions some animal laboratory models have been used. The (NZW X BXSB) F1 mice have been studied as autoimmune disease model and Harrington mouse as an immune purpura model. Studies in humans suggest that there are some differences in pathogenesis of acute or chronic ATP, particularly in reactive T cells. For example, in chronic form there are high levels of The (CD4+) activity concomitant with low levels of T supressor (CD8+) activity, while in acute form there is no dominance of any particular T cell activity or CD4+ is even decreased. Mytogen lymphocyte proliferation is increased in chronic ATP but decreased in acute form.


REFERENCES

  1. George JN. Thrombocytopenia due to enhanced platelet destruction by immunologic mechanisms. In: Williams Hematology, Fifth edition (E. Beutler, M Lichtman, B Coller and T Kipps eds) 1995 Pp 1315-1355. McGraw-Hill, New York.

  2. Frederiksen H, Schmidt K. The incidence of idiopathic purpura in adults increase with age. Blood 1999;94:909-913.

  3. Wendell FR. Treatment of chronic immune thrombocytopenia. Clin Hematol 1983;12:267-284.

  4. Pizzuto J, Ambriz R. Therapeutic experience on 934 adults with ITP: multicentric trial of the cooperative Latin American Group in hemostasis and thrombosis. Blood 1984;64:1179-1183.

  5. Schwartz RS. Autoimmunity and autoimmune diseases. In: Fundamental Immunology. Paul W E. Ed) Raven Press LTD. 3a Edición New York 1993 PP 1075.

  6. Sandier SG. The spleen and splenectomy in immune (idiopathic) thrombocytopenic purpura. Semin Hematol 2000;37 (suppl 1):10-12.

  7. Chadburn J. The spleen: anatomy and anatomical function. Semin Hematol 2000;37(suppl 1):13-21.

  8. George JN, Mayez A, El-Harake, Gary ER. Chronic idiophatic thrombocytopenic purpura. N Engl J Med 1994;331:1207-1211.

  9. van Leeuven EF, van der Ven JTHM, Engelfriet CP, van dem Borne. Specificity of autoantibodies in autoimmune thrombocytopenia. Blood 1982;59:23-26.

  10. Beardsley DS, Spiegel JE, Jacobs MM, Handin Rl, Lux IV SE. Platelet membrane glycoprotein contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. J Clin lnvest 1984;74:1701-1707.

  11. Tsubakio T, Tani P, Woods VL Jr, Mcmillan R. Autoantibodies against platelet GPllb/IIla in chronic ITP react with different epitopes. Br J Haematol 1987;67:345-348.

  12. McMilIan R, Tani P, Millard F, Berchtold L, Renshaw L, Woods VL. Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP. Blood 1987;70:1040-1045.

  13. Kekomaki R, Dawson B, McFarland J, Kunicki TJ. Localization of human platelet autoantigens to the cysteine-rich region of glycoprotein lIla. J Clin lnvest 1991;88:847-854.

  14. Fujisawa K, Tani P, O’Toole TE, Ginsberg MH, McMillan R. Different specificities of platelet-associated and plasma autoantibodies to platelet gpllb-IIIa in patients with chronic immune thrombocytopenic purpura. Blood 1992;79:1441-1446.

  15. Fujisawa K, Tani P, McMilIan R. Platelet-associated antibody to glycoprotein IIb/lIla from chronic immune thrombocytopenic purpura patients often binds to divalent cation-dependent antigens. Blood 1993;81:1284-1289.

  16. Berchtold P, McMiIlan R, Tani P, Sommerville-Nielsen S, Blanchette KS. Autoantibodies against platelet membrane glycoproteins in children with acute and chronic immune thrombocytopenic purpura. Blood 1989;74:1600-1602.

  17. Harrington WJ, Minnich V, Hollingsworth JW, Moore CV. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 1951;38:45-49.

  18. Shulman NR, Jordan JV Jr. Platelet immunology. In: Hemostasis and Thrombosis. 2nd ed. Edited by Colman R.W. J.B. Lippincott Co. Philadelphia.1987; PP 493-509.

  19. Mollison PL, Engelfried R, Contreras M. lmmunology of leucocytes, platelets and plasma components, in “Blood transfusion in clinical medicine”. Ninth edition. Blackwell Scientific Publications. 1993;PP 617-632.

  20. Berchtold P, Wenger M. Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment. Blood 1993;81:1246-1250.

  21. Kelton J, Gibbons S. Autoimmune platelet destruction: ITP. Semin Thromb Hemost 1982;8:83-104

  22. Karpatkin S. Autoimmune thrombocytopenic purpura. Semin Hematol 1985;22:260-288.

  23. Waters AH. Autoimmune thrombocytopenia: Clinical aspects. Semin Hematol 1992;29:18-25.

  24. Oksenhendler E, Bierling P, Chevret S, Deffraissy JF, Laurian Y, Clauvel JP. Splenectomy is safe and effective in human immunodeficiency virus-related immune thrombocytopenia. Blood 1993;82:29-32.

  25. Aster RH, George JN. Thrombocytopenia due to enhanced platelet destruction by immunologic mechanisms. In: Williams Hematology. Williams J, Beutier E, Lichtchman, Coller (Eds) McGraww-Hill Inc. 5a. Edición New York PP 1995, Pp 1370-1384.

  26. George JN. Platelet IgG: measurement, interpretation and clinical significance. In: Progress in Hemostasis and Thrombosis. Coller BS (Ed) Saunders WB. Edición Philadelphia 1991 PP 97-126.

  27. Karpatkin S. Autoimmune (idiopathic) thrombocytopenic purpura. Lancet 1997;349:1531-1536.

  28. George JN , Woolf SH, Raskob GE, Wasser JS Medort LM, Ballem PJ, et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 1996;88:340

  29. Lichtin A. The ITP practice guideline: what, why and for whom? Blood 1996;88:1-2.

  30. Andersen JC. Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy. N Engl J Med 1994;330:1560-1564.

  31. Giovanni E, Messora C, Longo G, Bertesi M. Long-term salvage treatment by cyclosporin in refractory autoimmune haematological disorders. Br J Haematol 1996;93:341-344.

  32. Ambríz R, Muñoz R, Pizzuto J, Quintanar E, Morales M, Avilés A. Low-dose autologous in vitro opsonized erythrocytes. Arch lntern Med 1987;147:105-108.

  33. Letsky EA, Greaves M. Guidelines on the investigation and management of thrombocytopenia in pregnancy and neonatal autoimmune thrombocytopenia. Br J Haematol 1996;95:21-26.

  34. Bussel JB. Splenectomy-sparing strategies for the treatment and long-term maintenance of chronic idiopathic immune thrombocytopenic purpura. Semin Hematol 2000;37(suppl 1):1-4.

  35. Bennett CL, Weinberg PD, Goloub RM, Bussel JB. The potential for treatment of idiopathic thrombocytopenic purpura with anti-D to prevent splenectomy: a predictive cost analysis. Semin Hematol 2000;37(suppl 1):26-30.

  36. George JN. Treatment options for chronic idiopathic (immune) thrombocytopenic purpura. Semin Hematol 2000;37(suppl 1):31-34.

  37. Tarantino MD. Treatment options for chronic immune (idiopathic) thrombocytopenic purpura in cbildren. Semin Hematol 2000;37(suppl 1):35-41.

  38. Scaradavou A. Splenectomy-sparing, long-term maintenance with anti-D for chronic immune (idiopathic) thrombocytopenic purpura: the New York Hospital experience. Semin Hematol 2000;37(suppl 1):42-44.

  39. Waintraub SE, Brody JI. Use of anti-D in immune thrombocytopenic purpura as a means to prevent splenectomy: case reports from two university hospital medical centers. Semin Hematol 2000;37(suppl 1):45-49.

  40. Ishihara T, Akizuki S, Yamamani S, Yamashita Y, Yokota T, Okusono Y, Takahashi M, Kamei T, Uchino F, Matsumoto N. Foamy cells in spleens and in granulomas induced by murine platelets, commercialized phospholipids, and erythrocyte membrane. Histological and ultrastructural studies. Acta Pathol Jpn 1983;33:943-958.

  41. Ishihara T, Akizuki S, Yokota T, Takahashi M, Uchino F, Matsumoto N. Foamy cells associated with platelet phagocytosis. Am J Pathol 1984;114:104-111.

  42. Corash L, Chen H.Y, Levin J, Baker G, Lu H, Mok Y. Regulation of thrombopoiesis: effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume. Blood 1987; 70:177-185.

  43. Stenberg PE, Levin J. Ultrastructural analysis of acute immune thrombocytopenia in mice: dissociation between alterations in megakaryocytes and platelets. J Cell Physiol 1989; 141:160-169.

  44. Oyaizu N, Yasumizn R, Miyama-Inaba M, Nomura S, Yoshida H, Miyawaki S, Shibata Y, Mitsuoka S, Yasunaga K, Moni S, Good R, Ikehara S. (NZW x BXSB) Fi Mouse: a new animal model for idiophatic thrombocytopenia purpura. J Exp Med 1988; 167: 2017-2022.

  45. Hang L, Izui MS, Dixon FJ. (NZW x BXSB) Fi hybrid: a model of acute lupus and coronary vascular disease with myocardial infarction. J Exp Med 1981;154:216-221.

  46. Mizutani H, Furubayash¡ T, Kuriu A, Take II, Tmiyama Y, Yoshida H, Nakamura Y, Inaba M, Kurata Y, Yonezawa T, Tarui S, Ikehara S. Analyses of thrombocytopenia in idiopathic thrombocytopenic purpura-prone mice by platelet transfer experiments between (NZW x BXSB)F1 and normal mice. Blood 1990;75:109-1812.

  47. Nlizutani H, Furubayashi T, Kashiwagi II, Honda S, Kurata Y, Yonezawa T, Tarui S, Ikehara S. Effects of splenectomy on immune thrombocytopenic purpura in (NZW x BXSB) F1 mice: analyses of platelet kinetics and anti-platelet antibody production. Thromb Haemost 1992; 67:563-566.

  48. Mizutani H, Furubayashi T, Imai Y, Kashiwagi H, Honda S, Kurata Y, Yonezawa T, Tarui S, Ikehara S. Mechanisms of corticosteroid action in immune thrombocytopenic purpura (ITP) experimental studies using ITP-prone mice, (NZW x BXSB) F1. Blood 1992;79:942-947.

  49. Nemoto K, Mae T, Saiga K, Matsumura E, Koike T. Autoimmune-prone (NZW x BXSB) F1 mice escape severe thrombocytopenia after tratment with deoxispergualin, an immunosupressant. Br J Haematol 1995;91:691-696.

  50. Mizutani H, Engelman RW, Kurata Y, Ikehara S, Good RA. Energy restriction prevents and reverses immune thrombocytopenic purpura (ITP) and increases life span of ITP-prone (NZW x BXSB) Fi mice. J Nutr 1994;124:2016-2023.

  51. Adachi Y, Inaba M, Inaba K, Nagata N, Kobayashi Y, Ikehara S. Functional analyses of B cells in (NZW x BXSB) Fi mice. Blood 1993;82:837-844.

  52. McKenzie SE, Taylor SM, Reilly MP, Surrey S, Schwartz E. immune-mediated thrombocytopenia is more severe in human FegRila transgenic mice than in wild type mice. Blood 1997;90(suppl 1):465.

  53. Campbel D, Beardsley DS, Tang C, Ertem M, Rockwell S, Kelley M. The “Harrington mouse”: an animal model for human immune thrombocytopenia. Blood 1997;90 (suppl 1):460.

  54. Louwes H, Zeinali Lathori OA, Vellenga E, de Wolf JT. Platelet kinetic studies in patients with idiopathic thrombocytopenic purpura. Am J Med 1999;106:430-434.

  55. Semple JW, Lazarus AH, Freedman J. The cellular immunology associated with autoimmune thrombocytopenic purpura: an update. Transfus Sci 1998;19:245-251.

  56. Semple JW, Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood 1991;78:2619-2625.

  57. Semple JW, Freedman J. Cellular immune mechanisms in chronic autoimmune thrombocytopenic purpura (ATP). Autoimmunity 1992;13:311-319.

  58. Furubayashi T, Mizutani H, Take H, Honda S, Torniyama Y, Katagiri S, Tamaid T, Tsubakio T, Kurata Y, Yonezawa T. Impaired supressor function of T cells induced by autologous mixed lymphocyte reaction in patients with idiopathic thrombocytopenic purpura. Acta Haematol. 1992;87:32.3-6.

  59. Ware RE, Howard TA. Phenotypic and clonal analysis of T lymphocytes in childhood immune thrombocytopenic purpura. Blood 1993;82:2137-2142.

  60. Koyanagi H, Kishida K, Shimoinura K, Kurokawa M, Deguchi T, Shimoda Y. lmmunological study of chilhdood acute ITP at onset. Pediatr Hematol Oncol 1992;9:11-19.

  61. García-Suárez J, Prieto A, Manzano L, Reyes E, Molto L, Alvarez-Mon M. T lymphocytes from autoimmune thrombocytopenic purpura show a defective activation and proliferation after cytoplasmic membrane and intracytoplasmic mitogenic signals. Am J Hematol 1993;44:1-8.

  62. García-Suárez J, Prieto A, Reyes E, Manzano L, Merino JL, Mvarez-Mon M. The clinical outcome of autoimmune thrombocytopenic purpura patients is related to their T cell immunodeficiency. Br J Haematol 1993;84:464-470.

  63. Ware RE, Howard TA. Elevated numbers of ganima-delta (gd +) T lymphocytes in children with immune thrombocytopenic purpura. J Clin Immunol 1994;14:237-247.

  64. Silirnomura T, Fujimura K, Takafuta T, Fujil T, Katsutani 5, Noda M, Fujimoto T, Kuramoto A. Oligoclonal accumulation of T cells in peripheral blood from patients with idiophatic thrombocytopenic purpura. Br J Haematol 1996;95:732-737.

  65. Hedlund-Treutiger I, Wahlstrom J, Elinder G. Role of the T cell receptor in idiopathic thrombocytopenic purpura (ITP). Acta Paediatr Suppl 1998;424:46-50.

  66. Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPllb-IIIa in immune thrombocytopenic purpura. Role in production of antiplatelet autoantibody. J Clin Invest 1998;102:1393-11402.

  67. Semple JW, Milev Y, Cosgrave D, Mody M, Hornstein A, Blanchette V, Freedman J. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura:relationship to platelet phenotype arid antiplatelet T-cell reactivity. Blood 1996;87:4245-4254.

  68. Semple JW. lmmunobiology of T helper cells and antigen-presenting cells in autoimmune thrombocytopenic purpura (ITP). Acta Paediatr Suppl 1998;424:41-45.

  69. Lazarus AH, Joy T, Crow AR. Analysis of transmembrane signalling and T cell defects associated with idiopathic thrombocytopenic purpura (ITP). Acta Pediatr Suppl 1998;424:21-25.

  70. Ikehara S, Kawamura M, Takao F, Inaba M, Yasurnizu R, Than S, Hisha H, Sugiura K, Koide Y, Yoshida TO. Organ-specific and systemic autoimmune diseases originate from defects in hematopoietic stem cells. Proc Natl Acad Sci USA 1990;87:8341-8344.

  71. Hymes KB, Karpatkin S. In vitro supressor T lymphocyte Dysfunction in autoimmune thrombocytopenia purpura associated with a complement-fixing antibody. Br J Haematol 1990;74:330-335.

  72. Pogliani EM, Della Volpe A, Casaroli Y, Maffe PF, Corneo G. Lymphocyte subsets in patients with idiopathic thrombocytopenic purpura during high-dose gamma globulin therapy. Allergol Immunopathol (Madr) 1991;19:113-116.

  73. Imbach PA. Harmful and beneficial antibodies in immune thrombocytopenic purpura. Clin Exp. Immunol. 1994;97(Suppl1):25-30.

  74. Nomura S, Yanabu M, Soga T, Kido H, Fukuroi T Yamaguchi K, Nagata H, Kokawa T. Yasunaga K. Analysis of idiopathic thrombocytopenic purpura patients with antiglycoprotein IIb lla or lb autoantibodies. 1991;86:25-30.

  75. lyon H, Fujisawa K, Akatsuka J. Autoantibodies and CD+ B cells in childhood immune thrombocytopenic purpura. Acta Paediatr Jpn 1995;37:325-330.

  76. Mizutani K, Azuma E, Komada Y, Ito M, Sakurai M, Hironaka T, Hirai K. An infantile case of cytomegalovirus induced idiopathic thrombocytopenic purpura with predominant proliferation of CD10 positive lymphoblast in bone marrow. Acta Paediatr Jpn 1995;37:71-74.

  77. Callea V, Cornis M, laria G, Sculli G, Morabito F, Lombardo VT. Clinical significance of H’a-DR+, CD 19+, CD 10+ inunature B-cell phenotype and CD34+ cell detection in bone marrow lymphocytes from children affected with Immune thrombocytopenic purpura. Haematologica 82:471-473.

  78. Denomme GA, Mahmoudi M, Cairs E, Bell DA. Immunoglobulin V region sequences of two human antiplatelet monoclonal autoantibodies derived from B cells of normal origin. J Autoimmun 1994; 7: 521-535.

  79. van Dijk-Hard Y, Feld S, Holmberg D, Lundkvist Y. Increased utilization of the VH6 gene family in patients with autoimmune idiophatic thrombocytopenic purpura. J Autoimmun 1999, 12: 57-63.

  80. Yang YY, Fischer P, Leu SJ, Zhu M, Woods VL, Chen PP. Possible presence of enhancing antibodies in idiopathic thrombocytopenic purpura. Br J Haematol 1999; 104: 69-80.

  81. Crossley AR, Dickinson AM, Proctor SJ, Calvert JE. Effects of interferon-alpha therapy on immune parameters in immune thrombocytopenic purpura. Autoimmunity 1996; 24: 81-100.

  82. Garcia-Suarez J, Prieto A, Reyes E, Manzano L, Arribalzaga K, Alvarez-Mon M. Abnormal gamma IFN and alpha TNF secretion in purified CD2+ cells from autoimmune thrombocytopenic purpura (ATP) patients: their implication in the clinical course of the disease. Am J Hematol 1995; 49: 271-276.

  83. Garcia-Suarez J, Prieto A, Reyes E, Manzano L, Arribalzaga K, Perez-Machado MA, Lopez-Rubio M, Manzano L, Alvarez-Mon M. Persistent lymphocytosis of natural killer cells in autoimmune thrombocytopenic purpura (ATP) patients after splenectomy. Br J Haematol 1995; 89: 653-655.

  84. Garcia-Suarez J, Prieto A, Reyes E, Manzano L, Merino JL, Alvarez-Mon M. Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56+ CD3- natural killer cells subset. Blood 1993; 82: 1538-1545.

  85. Otawa M, Kuriyama Y, Iwase O, Kawanishi Y, Miyazawa K, Aizawa S, Nehashi Y, Nakano M, Toyama K. Possible role of immunocompetent cells on periodic exacerbation of idiopathic thrombocytopenic purpura. Rinsko Ketsueki 1997; 38: 331-335.

  86. Zeigler ZR, Rosenfeld CS, Nemunaitis JJ, Besa EC, Shadduck RK. Increased macrophage colony-stimulating factor levels in immune thrombocytopenic purpura. Blood 1993; 81: 1251-1254.

  87. Nomura S, Yasunaga K, Fujimura K, Kuramoto A, Okuma M, Nomura T. High-doses intravenous gamma globulin reduces macophage colony-stimulating factor levels in idiopathic thrombocytopenic purpura. Int J Hematol 1996; 63: 227-234.

  88. Kosar A., Haznedaroglu I.C., Buyukasik Y., Ozcebe O., Kirazli S., Dundar S. Circulating thrombopoietin and interleukin-6 in newly diagnosed autoimmune versus aplastic thrombocytopenia. Haematologica 1998; 83: 1055-1056.

  89. Haznedaroglu IC, B uyukasik Y, Kosar A, Kirazh 5, Dundar SV. Thrombopoietin, interleukin-6 and P-selectin at diagnosis and during post-steroid recovery penod of patients with autoimmune thrombocytopenic purpura. Am Haematol 1998;77:165-170.

  90. Anderson J. Cytokines in idiopathic thrombocytopenic purpura (ITP). Acta Paediatr 1998;424 (suppl 1):61-64.

  91. Imbach P, Kuhne T. Immune thrombocytopenic purpura ffP. Vox Sang 1998;74(suppl 2):309-314.

  92. Erduran E, Asian Y, Miyazicioglu Y, Mocan H, Gedik Y. Plasma soluble interleukin-2 receptor levels in patients with idiopathic thrombocytopenic purpura. Am J Hematol 1998;57:119-123.

  93. Zirninerman SA, Malinoski FJ, Ware RE. lmmunologic effects of anti-D (WinRho-SD) in children with Immune thrombocytopenic purpura. Am J Hematol 1998;57:131-138.

  94. Cremer M, Schulze H, Linthorst G, Folman CC, Wehnert S, Strauss G, von dem Borne AE, Welte K, Bailmajer M. Serum leveis of thrombopoietin, IL-11, and IL-6 in pediatric thrombocytopenias. Am Hematol 1999;78:401-407.

  95. Haznedaroglu IC, Buyukasik Y, Kosar A, Ozcebe OI, Kirazli S, Dundar S. Selectins and IL-6 during the clinical course of idiophatic thrombocytopenic purpura. Acta Haematol 1999;101:16-2.

  96. Grabar P. Autoantibodies and the physiological role of immunoglobulins. Immunol Today 1983;4:337.

  97. Moller E. Mechanisms for induction of autoimmunity in humans. Acta Paediatr Suppl 1998;424:16-20.

  98. Hohmann AW, Booth K, Peters V, Gordon DL, Comacchio RM. Common epitope on HW p24 and human platelets. Lancet 1993;342:127-1275.

  99. Bettaieb A, Fromont P, Louache F. Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HW-related Immune thrombocytopenic purpura. Blood 1992;80:162-169.

  100. Bettaieb A, Oksenhendler E, Duedan N, Bierling P. Croos reactive antibodies between Hw-gp 120 and platelet gpIIIa (CD61) in Hw-related immune thrombocytopenic purpura. Clin Exp Immunol. 1996;103:19-23.

  101. Dorninguez V, Gevorkian G, Govezensky T, Rodriguez II, Viveros M, Cocho G, Macotela Y, Masso F, Pacheco M, Estrada JL, Lavalle C, Larralde C. Antigenic homology of HIV-1 gp41 and human platelet glycoprotein gpllla (integrin b3). J Acq Inun Def Syn Hum Retrovir 1998;17:385-390.

  102. Marti M, Feliu E, Campo E, Palacin A, Berga L, Casals FJ, Urbano Ispizua A, Cardesa A, Rozman C. Comparative study of spleen pathology in drug abusers with thrombocytopenia related to human immunodeficiency virus in infection and in patients with idiopathic thrombocytopenic purpura. A morphometric, immunohistochemical, and utrastructural study. Am J Clin Pathol 1993;100:633-642.

  103. Kodaira M, Hanai H, Kajimura M, Futami H, Maruyama Y, Sato Y, Arai H, Kaneko E. Further evidence that exacerbation of ulcerative colitis causes the onset of immune thrombocytopenic: a clinical case. Am J Gastroenterol 1999;94: 1408-1410.

  104. Macey MG, Newland AC. CD4 and CD8 subpopulation changes during higil dose intravenous immunoglobulin treatment. Br J Haematol 1990;76: 513-520.

  105. Liszewsky K. The complement system. In: Fundamental lmmunology, Third edition (Paul WE ed) 1993 pp34 Raven Press, New York.

  106. Engeifrieth CP, Reesink HW. The treatment of patients with autoimmune thrombocytopenia with WIgG anti-D. Vox Sanguinis 1999;76:250-255.

  107. Hohan-Kessary HS, Gershon H. Isoantibodies in immunoglobulin for intravenous treatment may causes eritrocyte secuestration. Vox Sanguinis 1999;77:33-39.

  108. Turner CE, Thorpe SJ, Brasher MDR, Thorpe IL Ami Rh D. activity of commercial intravenous immunoglobulin preparations. Vox Sanguinis 1999;76: 55-58.

  109. Jendreyko N, Uttenreuther-Fischer MM, Lerch II, Gaedicke G, Fischer P. Genetic origen of IgG antiantibodies cloned by phage display and anti-idiotypic parning from three patients with autoimmune thrombocvtopenia. Eur J Immunl 1998;28:4236-4237.

  110. Ericson SG, Coleman KD, Wardwell K, Baker S, Fanger MW, Guyre PM, Ely P. Monoclonal antibody 197 (anti-Fc gamma Rl) infusion in a patient with immune thrombocytopenia purpura (IIP) results in down-modulation of Fc gamma Rl on circulating monocytes. Br J Haematol 1996;92:718-724.

  111. Soubrane C, Tourani JM, Andrieu JM, Visonneau S, Beldjord K, Israel-Biet D, Mouawad IL Bussel J, Weil M, Khayat D. Biologic response to anti-CD 16 monoclonal antibody therapy in a human immunodeficiency virus-related immune thrombocytopenic purpura patient. Blood 1993;81:15-19.

  112. Zauli G, Re MC, Gugliotta L, Visani G, Vianelli N, Furlini G, La Placa M. Lack of compensatory megakaryocytopoiesis in HIV- 1 -seropositive thrombocytopenic purpura patients. AIDS 1991; 5:1345-1350.

  113. Jshji H, Oh H, Uchida Y, Nakamura H, Endo N, Asai T, Yoshida S. Effect of interferon (lEN) on refractory idiopathic thrombocytopenic purpura: administration of a 6 million units of recombinant IFN alpha-2b. lntem Med 1992; 31:1343-1347.

  114. Steliini R, Rossi G, Paraninfo G. Interferon therapy in intravenous users with HIVassociated idiopathic thrombocytopenic purpura. Haematologica 1992;77:418-420.

  115. Kumakura S, Ishikura H, Tsumura H, Endo J, Tsunematsu T. A favourable effect of long-term alpha-interferon therapy in refractory idiopathic thrombocytopenic purpura. Br J Haematol 1993;85:805-807.

  116. Cohn RJ, Schwyzer IL Hesseling PB, Poole JE, Naidoo J, van Heerden C. Alpha-Interferon therapy for severe chronic idiopathic thrombocytopenic purpura in children. Am J Hematol 1993;43:246-250.

  117. Vianelll N, Catani L, Gugliotta L, Belmonte MM, Cascione L, Colangeli V, Ricchi E, Mazza P, Mazzucconi MG, Chistolini A. Recombinant alpha-interferon 2b in the treatment of HW-related thrombocytopenia. ADS 1993;7:823-827.

  118. Fabris F, Sgarabotto D, Zanon E, Francavilla F, Zaggia F, Cadrobbi P, Girolami A. The effect of a single course of alpha-2B-interferon in patients with HIV-related and chronic idiopathic immune thrombocytopenia. Autoimmunity 1993;14:175-179.

  119. Dubbeld P, Hillen HF, Schouten HC. Interferon treatment of refractory idiopathic thrombocytopenic purpura. Eur J Haematol 1994;52:233-235.

  120. Northfelt DW, Kaplan LD, Abrams DI. Continuous, low-dose therapy with interferon alpha for human immunodeficiency virus (HIV)-related immune thrombocytopenic purpura. Am J Hematol 1991;38:238-239.

  121. Fujimura K, Takafuta T, Kuriya S, Abe T, Akatsuka J, Yasunaga K, Uchida T, Kawakita M, Kitamura K, Nomura T, Kuramoto A. Recombinant human interferon alpha2b (rIFN alpha-2b) therapy. Am J Hematol 1996;51:37-44.

  122. Vianelli N, Tazzari PL, Baravelli, Ricci F, Valdre L, Tura S. lnterferon-alpha 2b is not effective in the treatment of refractory immune thrombocytopenic purpura. Haematologica 1998;83:761-763.

  123. Shrestha R, Mckinley C, Buir B.M, Everson GT. Possible idiopathic thrombocytopenic purpura associated with natural alpha interferon therapy for chronic hepatitis C infection. Am JGastroenterol 1995;90:1146-1147.




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