Aguilar-Gaytán R, Mas-Oliva J

Idioma: Español
Referencias bibliográficas: 151
Paginas: 445-460
Archivo PDF: 313.08 Kb.

RESUMEN

El receptor pepenador (RPA) también conocido como “receptor scavenger” pertenece a una amplia familia de receptores que se agrupan con base en sus propiedades de unión a una serie de ligandos importantes. El RPA fue caracterizado inicialmente por su participación en el depósito del colesterol en la pared arterial durante la formación de la placa aterosclerótica. De igual forma se ha involucrado en el mecanismo de defensa del hospedero en contra de organismos patógenos infecciosos. Su estructura es un mosaico de regiones alfa hélice y dominios ricos en cisteínas. Este receptor tiene la habilidad de unir, además de lipoproteínas de baja densidad modificadas químicamente, un amplio rango de ligandos polianiónicos. Un ligando particular para el RPA es el péptido b-amiloide, el cual se ha involucrado directamente en diferentes procesos amiloidóticos. Estudios recientes realizados en nuestro laboratorio, así como los llevados a cabo por otros grupos de trabajo, consideran que la unión de este péptido al RPA activa respuestas de tipo inflamatorio con la correspondiente producción de estrés oxidativo.

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