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2017, Number 3

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Rev Mex Patol Clin Med Lab 2017; 64 (3)

Low triglyceride levels do not affect the calculation of low density lipoproteins by Friedewald’s formula

Arroyo HOM, Alcántara TSR, Sánchez JBJ

Language: Spanish
References: 10
Page: 110-113
PDF size: 221.59 Kb.


ABSTRACT

Introduction: Low density lipoproteins (LDL) are a biomarker for atherosclerosis and risk factor for cardiovascular diseases. Some clinical laboratories calculate LDL by Friedewald’s formula; however, some reports demonstrate it is inaccurate: when triglycerides are lower than 100 mg/dL, it overestimates LDL. Objective: To evaluate the correlation and agreement between the LDL precipitate method (LDLpp) and LDL calculated by the Friedewald’s formula when triglyceride levels are low, in university students. Methods: A cross-sectional, retrospective study was done. In November 2012, 195 students had triglyceride levels (Tg) ≤ 150 mg/dL and were divided into three groups: a) Tg ≤ 70 mg/dL, b) 71-100 mg/dL and c) 100-150 mg/dL. Results: Group A (p = 0.03) and group C (p = 0.00007) were significant, but group B (p = 0.80) was not statistically significant; all of them showed good correlation and agreement. In all three groups, the difference between LDLpp and LDL by Friedewald’s formula was not clinically significant. Conclusions: Low levels of triglycerides do not interfere with the calculation of LDL by Friedewald’s formula in our population.


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