Paz SP, Bazán BA, González GA, Espinoza HR, Moreno HP, Carazo PMM

Language: Spanish
References: 18
Page: 163-167
PDF size: 23.95 Kb.

ABSTRACT

Objective. To know the usefulness of the scintirenography in the evaluation of the function of the renal graft that receives mycophenolate mofetil as part of the immunosuppressive therapy. Material and method. It was accomplished an observational study, prospective, transverse and descriptive from March to November of 2000, to those which was accomplished scintirenography of their graft. Results. During the studied period 15 transplants were carried out, 73% received a graft from related live donator and 27% from corpse. 20%, received cyclosporine+azathioprine and the 80% took cyclosporine+mycophenolate+prednisone. There was meaningful difference in the function of the graft according to the parameters of serum creatinine, urinary volume day, effective renal plasmatic flow and glomerular filtration speed in the cases that azathioprine was administered, even rejection was associated. Conclusions. The correlation of the laboratory data, pathology and the clinic with the data of the renogram in the cases of rejection and viability of the graft, allows to establish that renogram is an effective study in the therapy with mycophenolate mofetil.

REFERENCES

1. Zuñiga AV. New combinations in immunosuppressor drugs therapy in renal transplantation. Nephron 2000; 2l: 23-32.

2. Calne RY, White DJG, Thiru S, et al. Cyclosporine A in patients receiving renal allografts from cadaver donors. Lancet 1978; 2: 1323.

3. Borel JF. Comparative Studing of in vitro and vivo drug effects on cell mediated cytotoxicity. Immnology 1976; 31: 613.

4. Cosimi AB, Burton RC, Colvin B, et al. Treatment of acute renal allografts rejection with OKT3 monoclonal antibody. Transplantation 1981; 32: 535.

5. Starzl TE, Tolo S, Fung J, et al. FK506 for liver kidney and pancreas transplantation. Lancet 1989; 2: 1000-4.

6. Amlot PL, Rawling E, Fernando OL, et al. Prolonged action of a Chimetric interleukin-2 receptor (CD25) monoclonal antibody used incadaveric renal transplantation. Transplantation 1995; 60: 748-56.

7. Tricontinental Mycophenolate mofetil renal transplant study group. A Bliend, randomized clinical trial of mycophenolate for the prevention of acute rejection in cadaveric renal transplantation. Transplantation 1996; 61: 1029.

8. Bullingham RE, Nicholls A, Hale M. Pharmacokinetics of mycophenolate mofetil: A short review. Transplant Proc 1996; 28: 925-9.

9. Nakashima R, Yamashita Y, Tomigushi S, et al. Functional evaluation of kidneys by Gd-DTPA enhanced turbo flash MR. Radiat Med 1996; 14: 251-6.

10. Hefty TR, Wilborn RL. Decreaced use of post-renal transplant imaging. Urology 1997; 49: 837-8.

11. Furukawa A, Murata K, Pak K, et al. Dynamic Gd-DPTA-enhanced MR imaging in evaluation of the function of transplanted kidneys. Nippon Igaku Hoshasen Gakkai Zasshi 1996; 56: 807-12.

12. Diethelm AG. Diagnosis of impaired renal function after kidey transplantation using renal scintigraphy, renal plasma flow and urinary scretion of hippurate. A NN Surg 1999; 191: 604-10.

13. Russell CD. Quality control of Tc-99 m-DPTA for GFR measurement. J. Nucl Med 1997; 23: 110-5.

14. Pérez TH. Programa de trasplante renal. Rev Hosp Jua Mex 2000; 67: 144-5.

15. Holm CA. Procuración multiorgánica y trasplante renal en niños y adolescentes: Experiencia con 300 casos. Cir Ciruj 1999; 67: 161-7.

16. Schweitzer EJ, Yoon S, Fink J, et al. Mycophenolate mofetil reduces the risk of acute rejection less in African, American, Dant in Caucasian Kidney recipient. Transplantation 1998; 65: 242-8.

17. Sollinger HW. Mycophenolate mofetil. Kidney Int 1995; 48 Supl 52: 14-7.

18. Tauxe WN. Prediction of urinary scretion of Hippurate. Eurjnucl Med 1998; 7: 102-8.