2017, Number 3
<< Back Next >>
Gac Med Mex 2017; 153 (3)
Infarto agudo al miocardio en jóvenes mexicanos asociado a síndrome metabólico
Mathiew-Quirós Á, Salinas-Martínez AM, Guzmán GFJ, Garza-Sagástegui MG, Guzmán-Delgado NE, Palmero-Hinojosa MG, Oliva-Sosa NE
Language: Spanish
References: 40
Page: 297-304
PDF size: 104.27 Kb.
ABSTRACT
Background: Acute coronary diseases are catastrophic, especially in young patients.
Objective: To determine the risk of metabolic syndrome (MS) for premature acute myocardial infarction (AMI), combined with familial, behavioral, and nutritional factors in the northeast of Mexico.
Material and methods: This is a case control study of patients less than 47 years of age with no personal history of angina, AMI, or cerebrovascular disease. Cases corresponded to patients with AMI (incident and primary cases; n = 55) and controls were blood donors located at the same hospital (n = 55). Behavioral, nutritional, and cardiometabolic risk factors were measured. Multivariate logistic regression was used for estimating odds ratios (OR) and 95% confidence intervals (95% CI).
Results: MS increased the risk for premature AMI (95% CI: 1.73-39.5) eightfold, followed by smoking (OR: 7.76; 95% CI: 1.27-47.3), family history of AMI or sudden death (OR: 11.0; 95% CI: 2.03-60.4), and sedentary lifestyle (OR: 2.26; 95% CI: 2.52-9.80), independent of potential confounders.
Conclusions: The study highlights the magnitude of the risk of MS for AMI in Mexican young adults. The phenomenon of coronary diseases among young adults needs essential attention from the health sector.
REFERENCES
Andrés E, León M, Cordero A, et al. Factores de riesgo cardiovascular y estilo de vida asociados a la aparición prematura de infarto agudo de miocardio. Rev Esp Cardiol. 2011;64:527-9.
Teixeira M, Sá I, Santos-Mendes J, Martins L. Síndrome coronária aguda no joven. Rev Port Cardiol. 2010;29:947-55.
Hernández- Garcilazo NH, Vázquez-Rodríguez EM, Vázquez Nava. Factores de riesgo de infarto agudo de miocardio en adultos jóvenes. Revista Electrónica Medicina, Salud y Sociedad. 2012;3(1): aprox. 10 p. (Consultado en septiembre de 2012.) Disponible en: http://cienciasdelasaluduv. com/site/index.php/septiembre-diciembre-2012/24-factores- de-riesgo-de-infarto-agudo-de-miocardio-en-adultos-jovenes
Alonso-Mariño A, Alonso Marino O, Grau Abalos R. Infarto agudo de miocardio en jóvenes ingresados en cuidados intensivos. CorSalud. 2012;4:20-9.
Mähönen MS, McElduff P, Dobson AJ, Kuulasmaa KA, Evans AE. Current smoking and the risk of non-fatal myocardial infarction in the WHO MONICA Project populations. Tobacco Control. 2004;13:244-50.
Ozkan B, Kadir O, Duran M, et al. Relationship between mean platelet volume and atherosclerosis in young patients with ST elevation myocardial infarction. Angiology. 2012;64:371-4.
Rubin J, Borden W. Coronary heart disease in young adults. Curr Atheroscler Rep. 2012;14:140-9.
Christus T, Shukkur A, Koshy T, Zubaid M, Hayat N, Alsayegh A. Coronary artery disease in patients aged 35 or less - a different beast? Heart Views. 2011;12:7-11.
Von Eyben FE, Mouritsen E, Holm J, et al. Intra-abdominal obesity and metabolic risk factors: a study of young adults. Int J Obes Relat Metab Disord. 2003;27:941-9.
Substance Abuse and Mental Health Services Administration, Office of Applied Studies. Drug Abuse Warning Network, 2005: national estimates of drug-related emergency department visits. DAWN Series D-29. DHHS Publication No. (SMA) 07-4256. Rockville: Substance Abuse and Mental Health Services Administration, Office of Applied Studies; 2007.
Wood DM, Dargan PI. Putting cocaine and cocaine-associated cardiac arrhythmias into epidemiological and clinical perspective. Br J Clin Pharmacol. 2010;69:443-7
Mittleman MA, Mintzer D, Maclure M, Tofler GH, Sherwood JB, Muller JE. Triggering of myocardial infarction by cocaine. Circulation. 1999;99:2737-41.
Yunyun W, Tong L, Yingwu L, et al. Analysis of risk factors of ST-segment elevation myocardial infarction in young patients. BMC Cardiovasc Dis. 2014;14:179.
Ergelen M. Comparison of outcomes in young versus non young patients with ST elevation myocardial infarction treated by primary angioplasty. Coron Artery Vnitr Lek. 2012;58:721-9.
Wiesbauer F, Blessberger H, Azar D, et al. Familial-combined hyperlipidaemia in very young myocardial infarction survivors (≤ 40 years of age). Eur Heart J. 2009;30:1073-9.
Ranjith N, Pegoraro RJ. Obesity-associated genetic variants in Young Asian Indians with the metabolic syndrome and myocardial infarction. Cardiovasc J Afr. 2011;22:25-30.
Cannon CP. Mixed dyslipidemia, metabolic syndrome, diabetes mellitus, and cardiovascular disease: clinical implications. Am J Cardiol. 2008;102:5L-9L.
Martín M, Rodríguez J, Batalla A. Enfermedad coronaria en jóvenes y síndrome metabólico. Med Clin (Barc). 2006;126:514-8.
López-Sandon J, López de Sa E. Nuevos criterios de diagnóstico de infarto de miocardio: orden en el caos. Rev Esp Cardiol. 2001;54:669-74.
Xunta de Galicia y Organización Panamericana de la Salud. EpiDat. Versión 3.1, 2006.
Zimmet P, Alberti M, Serrano M. Una nueva definición mundial del síndrome metabólico propuesta por la Federación Internacional de Diabetes: fundamento y resultados. Rev Esp Cardiol. 2005;58:1371-6.
Archer DF. La menopausia prematura aumenta el riesgo cardiovascular. Revista del Climaterio. 2010;13:67-73.
Sederholm S, Stenestrand U, Lagerqvist B, Wallentin L, Swahn E. Gender perspective on risk factors, coronary lesions and long-term outcome in young patients with ST-elevation myocardial infarction. Heart. 2010;96:453-9.
Brouwers M, Greevenbroek J, Stehouwer C, Graaf J, Stalenhoef A. The genetics of familial combined hyperlipidaemia. Nat Rev Endocrinol. 2012;8:352-62.
Mata P, Alonso R, Ruiz A, et al. Hiperlipidemia familiar combinada: documento de concenso. Aten Primaria. 2014;46:440-6.
Instituto Nacional de Salud Pública. Encuesta Nacional de Salud y Nutrición 2012. Resultados nacionales. México: Instituto Nacional de Salud Pública; 2012.
Ramírez R, Agredo R. El sedentarismo es un factor predictor de hipertrigliceridemia, obesidad central y sobrepeso. Revista Colombiana de Cardiología. 2002;19:75-9.
Ekelund UF, Ward H, Norat T, et al. Physical activity and all cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Am J Clin Nutr. 2015;101:613-21.
Hbejan K. Smoking effect on ischemic heart disease in young patients. Heart Views. 2011;12:1-6.
Méndez M, Martínez G, Martínez A. Infarto agudo al miocardio en pacientes menores de 40 años. Características clínicas, angiográficas y alternativas terapéuticas. Revista Chilena de Cardiología. 2013;32:21-7.
Villatoro-Velázquez JA, Medina-Mora ME, Fleiz-Bautista C, et al. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz; Instituto Nacional de Salud Pública; Secretaría de Salud. Encuesta Nacional de Adicciones 2011: Reporte de drogas. México DF, México: INPRFM; 2012.
Barquera S, Campos I, Hernández L, Pedroza A, Rivera JA. Prevalencia de obesidad en adultos mexicanos. ENSANUT 2012. Salud Pública de México. 2013;55:S151-60.
Centers for Disease Control and Prevention (CDC). Prevalence of abnormal lipid levels among youths. United States 1999-2006. MMWR Morb Mortal Wkly Rep. 2010;59:22-30.
Wilmot E, Davies M, Yates T, Benhalima K, Lawrance I, Khuntr K. Type 2 diabetes adults: the emerging UK epidemic. Postgrad Med J. 2010;86:711-8.
Chung E, Curran P, Sivasankaran S, et al. Prevalence of metabolic syndrome in patients ≤ 45 years of age with acute myocardial infarction having percutaneous coronary intervention. Am J Cardiol. 2007;100:1052-5.
Murguía-Romero M, Jiménez-Flores R, Sigrist-Flores S, Tapia-Pancardo D, Jiménez-Ramos A, Villalobos-Molina R. Síndrome metabólico en jóvenes mexicanos: análisis de sensibilidad de sus componentes. Nutr Hosp. 2015;32:189-95.
Mathiew-Quirós A, Salinas-Martínez AM, Hernández-Herrera RJ, Gallardo- Vela JA. Síndrome metabólico en trabajadores de un hospital de segundo nivel. Rev Med Inst Mex Seguro Soc. 2014;52:580-7.
Hassain N, Gharib S, Ramly M, Meged M, Makram A. Metabolic syndrome and coronary artery disease in young Egyptians presenting with acute coronary syndrome. Kasr Al Ainy Medical Journal. 2015;21:27-23
Turhan A, Yasar A, Basar N, Biser A, Erbay R, Yetkin E. High prevalence of metabolic syndrome among young women with premature coronary artery disease. Coron Artery Dis. 2005;16:37-40.
Iribarren C, Go A, Husson G, et al. Metabolic syndrome and early-onset coronary artery disease. Is the whole greater than its parts? J Am Coll Cardiol. 2006;48:1800-7.