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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2005, Number 2

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Rev Biomed 2005; 16 (2)

Haemorrhagic manifestations in dengue.

Rivas-Llamas R, Chaín-Castro RA, Murillo-Llanes J, Ramírez-Zepeda MG, Gadea-Alvarez T, López-López E

Language: Spanish
References: 23
Page: 87-94
PDF size: 49.97 Kb.


ABSTRACT

Objective.- Describe the clinical and epidemiological manifestations in patients with dengue fever (DF) and dengue haemorragic fever (DHF).
Materials and Methods.- A cross-sectional study of 231 cases of dengue taken care from the General Hospital of Culiacán "Dr. Bernardo J. Gastelum" from September to November, 2003, were classified according to the WHO criteria. The statistical program v6 Stata was used.
Results.- 209 (90.48%) were DF and 22 (9.52%) DHF. The mean age was 34.5 ± 15 years. The DF predominated in women, with 129 cases (61.7%), and DHF in men with 17 cases (77.3%). For DHF patients went to the hospital in 4.7 ± 2 days, compared with 3.4 ± 2.2 for DF (p = 0.004). Headache, retroocular pain, arthralgias, diarrhea, and vomiting were more frequent in DHF (p ‹0.05). In DF the haemorrhagic manifestations, plasma leakage, and thrombocytopenia occurred in 24.8, 6.7, and 36.7% of cases respectively; petechias, gingivorragia, and epistaxis were associated with thrombocytopenia under 20,000/μL (p‹0.05). Other haemorrhagic manifestations were not associated with thrombocytopenia. Neutropenia, lengthy APTT, elevation of the glutamic-oxalacetic transaminase occurred more frequently in the DHF patients (p ‹0.05).
Conclusions.- The males with fever, vomiting, and gingivorragia are strongly associated with DHF, but not with having had dengue previously. Higher hemoconcentration is associated with the severity of thrombocytopenia.


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