Cacho-Díaz B, Lorenzana-Mendoza NA, Reyes-Soto G, Cantú LD, Herrera-Gómez Á, Granados-García M

Language: Spanish
References: 38
Page: 30-38
PDF size: 285.36 Kb.

ABSTRACT

Objective: To describe Central Nervous System metastases from cervical cancer experience, of a referral hospital center in Mexico, and the comparison to other published cases.
Methods: We reviewed all patients files with Cervical Cancer treated at our referral center, from May 2009 to August 2015.
Results: We found 28 patients with Cervical Cancer and Central Nervous System metastases. Mean interval between initial Cervical Cancer and CNSm: 46 months; 57% of patients had lung metastases at the time of CNSm were diagnosed. Headache was the most common symptom, followed by altered mental status, focal weakness and persisting nausea/vomiting. We compared our findings with other 124 found in the literature.
Conclusion: The present study describes the largest series of patients with Central Nervous System metastases from Cervical Cancer, this rare complication should be suspected in patients with Cervical Cancer that present neurological symptom.

REFERENCES

1. Meneses-García A R-GL, Beltrán-Ortega A, Sánchez-Cervantes F, Tapia-Conyer R, Mohar A. Principales neoplasias malignas en México y su distribución geográfica (1993-2002). Revista de Investigación Clínica. 2012;64(4):322-9.

2. Cannistra SA, Niloff JM. Cancer of the uterine cervix. N Engl J Med. 1996;18;334(16):1030-8.

3. Waggoner SE. Cervical cancer. Lancet. 2003 Jun 28;361(9376):2217-25.

4. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9-29.

5. Badib AO, Kurohara SS, Webster JH, Pickren JW. Metastasis to organs in carcinoma of the uterine cervix. Influence of treatment on incidence and distribution. Cancer. 1968;21(3):434-9.

6. Tangjitgamol S, Levenback CF, Beller U, Kavanagh JJ. Role of surgical resection for lung, liver, and central nervous system metastases in patients with gynecological cancer: a literature review. Int J Gynecol Cancer. 2004;14(3):399-422.

7. Henriksen E. The lymphatic spread of carcinoma of the cervix and of the body of the uterus; a study of 420 necropsies. Am J Obstet Gynecol. 1949;58(5):924-42.

8. Posner JB, Chernik NL. Intracranial metastases from systemic cancer. Adv Neurol. 1978;19:579-92.

9. Saphner T, Gallion HH, Van Nagell JR, Kryscio R, Patchell RA. Neurologic complications of cervical cancer. A review of 2261 cases. Cancer. 1989;64(5):1147-51.

10. Cormio G, Pellegrino A, Landoni F, Regallo M, Zanetta G, Colombo A, et al. Brain metastases from cervical carcinoma. Tumori. 1996;82(4):394-6.

11. Fagundes H, Perez CA, Grigsby PW, Lockett MA. Distant metastases after irradiation alone in carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys. 1992;24(2):197-204.

12. Hwang JH, Yoo HJ, Lim MC, Seo SS, Kang S, Kim JY, et al. Brain metastasis in patients with uterine cervical cancer. J Obstet Gynaecol Res. 2013;39(1):287-91.

13. Viswanathan AN, Deavers MT, Jhingran A, Ramirez PT, Levenback C, Eifel PJ. Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. Gynecologic oncology. 2004 ;93(1):27-33.

14. Weed JC, Jr., Graff AT, Shoup B, Tawfik O. Small cell undifferentiated (neuroendocrine) carcinoma of the uterine cervix. J Am Coll Surg. 2003;197(1):44-51.

15. Kumar L, Tanwar RK, Singh SP. Intracranial metastases from carcinoma cervix and review of literature. Gynecologic oncology. 1992;46(3):391-2.

16. Cordeiro JG, Prevedello DM, da Silva Ditzel LF, Pereira CU, Araujo JC. Cerebral metastasis of cervical uterine cancer: report of three cases. Arq Neuropsiquiatr. 2006;64(2A):300-2.

17. Batson OV. The Function of the Vertebral Veins and Their Role in the Spread of Metastases. Annals of surgery. 1940;112(1):138-49.

18. Coronel J, Cetina L, Pacheco I, Trejo-Becerril C, Gonzalez-Fierro A, de la Cruz-Hernandez E, et al. A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer. Preliminary results. Medical oncology. 2011;28 Suppl 1:S540-6.

19. Friedman M, Nissenbaum M, Lakier R, Browde S. Brain metastases in early cancer of the uterine cervix. A case report. S Afr Med J. 1983;64(13):498-9.

20. Lefkowitz D, Asconape J, Biller J. Intracranial metastases from carcinoma of the cervix. Southern medical journal. 1983;76(4):519-21.

21. Robinson JB, Morris M. Cervical carcinoma metastatic to the brain. Gynecologic oncology. 1997;66(2):324-6.

22. Ikeda S, Yamada T, Katsumata N, Hida K, Tanemura K, Tsunematu R, et al. Cerebral metastasis in patients with uterine cervical cancer. Jpn J Clin Oncol. 1998;28(1):27-9.

23. Ziainia T, Resnik E. Hemiballismus and brain metastases from squamous cell carcinoma of the cervix. Gynecologic oncology. 1999;75(2):289-92.

24. Mahmoud-Ahmed AS, Suh JH, Barnett GH, Webster KD, Kennedy AW. Tumor distribution and survival in six patients with brain metastases from cervical carcinoma. Gynecologic oncology. 2001;81(2):196-200.

25. Omari-Alaoui HE, Gaye PM, Kebdani T, El Ghazi E, Benjaafar N, Mansouri A, et al. Cerebellous metastases in patients with uterine cervical cancer. Two cases reports and review of the literature. Cancer Radiother. 2003;7(5):317-20.

26. Salvati M, Caroli E, Orlando ER, Nardone A, Frati A, Innocenzi G, et al. Solitary brain metastases from uterus carcinoma: report of three cases. J Neurooncol. 2004;66(1-2):175-8.

27. Mavrakis AN, Halpern EF, Barker FG, 2nd, Gonzalez RG, Henson JW. Diagnostic evaluation of patients with a brain mass as the presenting manifestation of cancer. Neurology. 2005;65(6):908-11.

28. Kastritis E, Moulopoulos LA, Politi E, Kostis E, Pissakas G, Dimopoulos MA, et al. Intramedullary spinal cord and leptomeningeal metastases in a patient with carcinoma of the uterine cervix. Gynecologic oncology. 2006 ;102(1):124-7.

29. Agrawal A, Kumar A, Sinha AK, Kumar M, Pandey SR, Khaniya S. Intracranial metastases from carcinoma of the cervix. Singapore medical journal. 2007;48(5):e154-6.

30. Balaji R, Ramachandran K, Kumar A, Krishnakumar AS, Venugopal M. Pachymeningeal metastasis from squamous cell carcinoma of the uterine cervix with involvement of the optic nerve: case report and review of the literature. Cancer Imaging. 2007;7:138-40.

31. Chura JC, Shukla K, Argenta PA. Brain metastasis from cervical carcinoma. Int J Gynecol Cancer. 2007;17(1):141-6.

32. Ignatius RT, Wills SM, Nadeau L, Deperalta-Venturina M, Weiner S. Leptomeningeal carcinomatosis due to squamous cell carcinoma of the uterine cervix associated with HPV-45. J Clin Oncol. 2008;26(1):154-6.

33. Ogawa K, Yoshii Y, Aoki Y, Nagai Y, Tsuchida Y, Toita T, et al. Treatment and prognosis of brain metastases from gynecological cancers. Neurol Med Chir (Tokyo). 2008 ;48(2):57-62; discussion -3.

34. Park SH, Ro DY, Park BJ, Kim YW, Kim TE, Jung JK, et al. Brain metastasis from uterine cervical cancer. J Obstet Gynaecol Res. 2010;36(3):701-4.

35. Komiyama S, Nishio E, Torii Y, Kawamura K, Oe S, Kato R, et al. A case of primary uterine cervical neuroendocrine tumor with meningeal carcinomatosis confirmed by diagnostic imaging and autopsy. Int J Clin Oncol. 2011 Oct;16(5):581-6.

36. 36. Setoodeh R, Hakam A, Shan Y. Cerebral metastasis of cervical cancer, report of two cases and review of the literature. Int J Clin Exp Pathol. 2012;5(7):710-4.

37. Dadlani R, Ghosal N, Hegde AS. Solitary cerebellous metastasis after prolonged remission in a case of uterine cervical adenocarcinoma. Journal of neurosciences in rural practice. 2012;3(2):185-7.

38. Brown Iii JV, Epstein HD, Kim R, Micha JP, Rettenmaier MA, Mattison JA, et al. Rapid manifestation of CNS metastatic disease in a cervical carcinoma patient: a case report. Oncology. 2007;73(3- 4):273-6.