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Federación Mexicana de Ginecología y Obstetricia, A.C.

2017, Number 05

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Ginecol Obstet Mex 2017; 85 (05)

HOMA-IR and QUICKI reference values during pregnancy in Mexican women

Reyes-Muñoz E, Martínez-Herrera EM, Ortega-González C, Arce-Sánchez L, Ávila-Carrasco A, Zamora-Escudero R

Language: Spanish
References: 27
Page: 306-313
PDF size: 294.15 Kb.


ABSTRACT

Objetive: To determine the reference values of Homeostasis Model Assessment Insulin Resistance, (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) to define insulin resistance (IR) in women without pregnancy (WP) and each trimester of pregnancy among Mexican women.
Methods: Cross-sectional study, women without pregnancy and pregnant women age ›18 years, without pathologies, pre-pregnancy body mass index (BMI) between 18.5-24.9 kg/m2 were included. All participants underwent CTOG 75gr-2h to rule out diabetes. We excluded women with gestational diabetes or any pre-pregnancy pathology, pre-pregnancy BMI ‹18.5 or ≥25 kg/m2 and multiple pregnancy. Percentiles 5 and 95 were calculated as reference values to define RI by HOMA-IR and QUICKI in women without pregnancy and each trimester of pregnancy.
Results: A total of 400 women were included, which were grouped as follows: Group of women without pregnancy (SE): n = 42, quarter Group (T) 1: n = 82, T2 Group: n = 159 and T3 group: n = 117. The reference values of HOMA-IR for the 5th and 95th percentile were: 0.33-2.6, 0.35-1.6, 0.40-2.9 and 0.38-2.6 and QUICKI: (0.33 to 0.46, 0.35 to 0.46, 0.32 to 0.45 and 0.33- 0.45, for groups SE, T1, T2 and T3, respectively.
Conclusion: The reference value of HOMA-IR to define RI in Mexican women should be ≥2.6 and the T1 ≥1.6, T2 pregnancy: ≥2.9 and T3 ≥2.6 and QUICKI in women ‹0.33, T1 ‹0.35, T2 ‹0.32 and T3 ‹0.33.


REFERENCES

  1. Wilcox G. Insulin and insulin resistance. Clin Biochem Rev 2005;26:19-39.

  2. Reina M, David M, Roque A, Tula H. Insulina-resistencia y embarazo. Rev Endocrinol Ginecol Rep 2008;(27). [en línea]. Dirección URL: . (Consulta: 12 de mayo 2016).

  3. Kocyigit Y, Bayhan G, Atamer Y. Serum levels of leptin, insulin-like grow factor-1 and insulin-like grow factor binding protein-3 in women preeclampsia and their relationship to insulin reistance. Gynecol Endocrinol 2004;18(6):341-8.

  4. Wolf M, Hubel CA, Lam C, Sampson M, Ecker JL, Ness RB, Rajakumar A, Daftary A, Shakir AS, Seely FW, Roberts JM, Sukhatme VP, Karumanchi SA, Thadhani R. Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance. J Clin Endocrinol Metab 2004;89(12):6239-43.

  5. Berkowitz KM. Insulin resistance and preeclampsia. Clin Perinatol. 1998;25(4):873-85.

  6. Temming LA, Tuuli MG, Stout MJ, Macones GA, Cahill AG. Maternal and perinatal outcomes in women with insulin resistance. Am J Perinatol. 2016;33(8):776-80.

  7. Mastrogiannis DS, Spiliopoulos M, Mulla W, Homko CJ. Insulin resistance: the possible link between gestational diabetes mellitus and hypertensive disorders of pregnancy. Curr Diab Rep. 2009;9(4):296-302.

  8. Ryan E, Enns L. Role of gestational hormones in the induction of insulin resistance. J Clin Endocrinol Metab. 1988;67(2):341.

  9. Kauffman RP, Castracane VD, Peghee D, Baker TE, Van Hook JW. Detection of gestational diabetes mellitus by homeostatic indices of insulin sensitivity: a preliminary study. Am J Obstet Gynecol. 2006;194(6):1576-82.

  10. Harreiter J, Simmons D, Desoye G, Corcoy R, Adelantado JM, Devlieger R, et al. IADPSG and WHO 2013 Gestational Diabetes Mellitus Criteria Identify Obese Women With Marked Insulin Resistance in Early Pregnancy. Diabetes Care. 2016;39.

  11. Borai A, Livingstone C, Kaddam I, Ferns G. Selection of the appropriate method for the assessment of insulin resistance. BMC Med Res Methodol. 201; 23;11:158.

  12. Geloneze B, Vasques A, Stabe C, Pareja J, Rosado L, Queiroz E, et al. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS). Arq Bras Endocrinol Metabol. 2009;53(2):281-7.

  13. Christoffersen B, Ribel U, Raun K, Golozoubova V, Pacini G. Evaluation of different methods for assessment of insulin sensitivity in Gottingen minipigs: introduction of a new, simpler method. Am J Physiol Regul Integr Comp Physiol. 2009;297(4):R1195-201.

  14. Wallace TM, Levy J, Matthews D. Use and abuse of HOMA modeling. Diabetes Care. 2004 ;27(6):1487-95.

  15. Gayoso-Diz P, Otero-González A, Rodriguez-Alvarez MX, Gude F, García F, De Francisco A, et al. Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross- sectional study. BMC Endocr Disord. 2013;13:47.

  16. Rabasa-Lhoret R, Laville M. How to measure insulin sensitivity in clinical practice?. Diabetes Metab. 2001;27(2 Pt 2):201-8.

  17. Szosland K, Lewiński A. In quest for method of insulin resistance assessment in everyday clinical practice-Insulin resistance indices. Diabetes Metab Syndr. 2016;10(Suppl 1):S120-5.

  18. Otten J, Ahrén B, Olsson T. Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis. Diabetologia. 2014;57(9):1781-8.

  19. Holzinger U, Kitzberger R, Fuhrmann V, Funk GC, Madl C, Ratheiser K. Correlation of calculated indices of insulin resistance (QUICKI and HOMA) with the euglycaemic hyperinsulinaemic clamp technique for evaluating insulin resistance in critically ill patients. Eur J Anaesthesiol. 2007;24(11):966-70.

  20. Legro RS, Castracane VD, Kauffman RP. Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet Gynecol Surv. 2004;59(2):141-54.

  21. Garmendia ML, Lera L, Sánchez H, Uauy R, Albala C. Homeostasis model assessment (HOMA) values in Chilean elderly subjects. Rev Med Chil. 2009;137(11):1409-16.

  22. Acosta AM, Escalona M, Maiz A, Pollak F, Leighton F. Determination of the insulin resistance index by the Homeostasis Model Assessment in a population of Metropolitan Region in Chile. Rev Med Chil. 2002 ;130(11):1227-31.

  23. Katz A, Nambi S, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85(7):2402-10.

  24. Esteghamati A, Ashraf H, Esteghamati AR, Meysamie A, Khalilzadeh O, Nakhjavani M; et al. Optimal threshold of homeostasis model assessment for insulin resistance in an Iranian population: the implication of metabolic syndrome to detect insulin resistance. Diabetes Res Clin Pract. 2009;84(3):279-87.

  25. Geloneze B, Vasques AC, Stabe CF, Pareja JC, Rosado LE, Queiroz EC, et al. HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS). Arq Bras Endocrinol Metabol. 2009;53(2):281-7.

  26. Timóteo AT, Miranda F, Carmo M, Ferreira R. Optimal cut-off value for homeostasis model assessment (HOMA) index of insulin-resistance in a population of patients admitted electively in a Portuguese cardiology Ward. Acta Med Port. 2014;27(4):473-9

  27. Seraphim AP, Chiba FY, Pereira RF, Mattera MS, Moimaz SA, Sumida DH. Relationship among periodontal disease, insulin resistance, salivary cortisol, and stress levels during pregnancy. Braz Dent J. 2016;27(2):123-7.




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