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Federación Mexicana de Ginecología y Obstetricia, A.C.

2017, Number 05

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Ginecol Obstet Mex 2017; 85 (05)

Clinical and biochemical risk factors for hypertension in women with previous diagnosis of hypertensive states of pregnancy

Vázquez-Rodríguez M, Pérez-Adán M, Álvarez-Silvares E, Alves-Pérez MT

Language: Spanish
References: 41
Page: 273-288
PDF size: 280.58 Kb.


ABSTRACT

Objetive: To determine the incidence of long-term hypertension in women who were previously diagnosed of hypertensive pregnancy states. Secondarily identify clinical and biochemical gestational factors that increase the subsequent risk of hypertension.
Material and Methods: Study of nested cases and controls in a cohort. Patients were selected who were diagnosed of “hypertensive pregnancy disorders” between 2000 and 2010 and two subgroups were differentiated: Group cases: women diagnosed with “hypertensive pregnancy disorders” and subsequent development of hypertension. – Control group: women with the diagnosis of “hypertensive pregnancy disorders” and who at the time of follow-up did not develop hypertension. The mean time elapsed until the diagnosis of hypertension was 11.79 years (95% CI: 10.6-12.90).
Parametric and non-parametric tests were performed to determine the Potential association between the study variables with the later hypertension. In addition, to detect the relationship or interaction between the different variables, their correlations were studied. The influence of the different gestational variables on the subsequent occurrence of arterial hypertension as a function of the time parameter was obtained through the Kaplan Meier survival study and the COX models were applied for the categorical variables.
Results: We studied 121 patients diagnosed with “hypertensive pregnancy disorders”. The subsequent incidence of hypertension was 41.32%. As a risk factor for posterior hypertension in gestation index, only multiparity was identified. None of the other parameters studied presented statistical significance.
Conclusions: The hypertensive pregnancy disorders are a risk factor for the subsequent development of hypertension. It is not possible to determine, based on clinical or biochemical gestational parameters, which will present a higher incidence of future hypertension. All pregnant women with this pathology should be informed of the long-term hypertensive risk.


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