2017, Number 3
<< Back Next >>
Rev Mex Urol 2017; 77 (3)
Medical management of enuresis in children: current aspects
Salazar-Ozuna WA, Aragón-Castro MA, Vázquez-Niño CL, Ruvalcaba-Oceguera G, Gutiérrez-Rosales R, Téllez-Díaz TJA
Language: Spanish
References: 40
Page: 230-237
PDF size: 221.02 Kb.
ABSTRACT
Enuresis is a frequent pathology in all cultures, but is abnormal after
5 years of age, contributing to conditions of social isolation in the
child and alterations in the family nucleus. The aim of this study was
to report on current aspects of enuresis treatment. The pathophysiology
of this disorder ranges from bladder capacity alterations, the quantity
of urine produced during the night, and the incapacity of the child
to wake up and use the bathroom. Part of the treatment is the correct
diagnosis and precise motivation of both the child and parents to carry
out the ideal management, utilizing behavioral therapies, such as setting
a wake-up alarm, or drug therapies, such as desmopressin and
imipramine. There is a 3-month follow-up with treatment suspension
for one week to evaluate and determine whether treatment can be
permanently suspended or continued with a minimum effective dose,
achieving the maintenance of dry nocturnal episodes.
REFERENCES
Anne JW. Childhood enuresis. Paediatr Child Health 2016;26:353-359.
Nevéus T, von Gontard A, Hoebeke P, et al. The standardization of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children's Continence Society. J Urol 2006;176(1):314.
Israel F, Alexander von G, Mario DG. Evaluation and treatment of nonmonosymptomatic nocturnal enuresis: A standardization document from the International Children’s Continence Society. J Pediatr Urol 2013;9:234-243.
Fergusson DM, Horwood LJ, Shannon FT. Factors related to the age of attainment of nocturnal bladder control: an 8-year longitudinal study. Pediatrics 1986;78(5):884.
Bakker E, van Sprundel M, van der Auwera JC, van Gool JD, Wyndaele JJ. Voiding habits and wetting in a population of 4,332 Belgian schoolchildren aged between 10 and 14 years. Scand J Urol Nephrol 2002;36(5):354.
Butler RJ, Golding J, Northstone K. Nocturnal enuresis at 7.5 years old: prevalence and analysis of clinical signs. BJU Int 2005;96:404-10.
An-Sofie G, Bente S, Olivier O, Piet H. Long-term followup of children with nocturnal enuresis: increased frequency of nocturia in adulthood. J Urol 2014;191:1866-1871.
Von Gontard A, Freitag CM, Seifen S, Pukrop R, Röhling D. Neuromotor development in nocturnal enuresis. Dev Med Child Neurol 2006;48(9):744.
Watanabe H, Azuma Y. A proposal for a classification system of enuresis based on overnight simultaneous monitoring of electroencephalography and cystometry. Sleep 1989;12(3):257.
Robson WL. Clinical practice. Evaluation and management of enuresis. N Engl J Med 2009;360(14):1429.
Kawauchi A, Tanaka Y, Naito Y, Yamao Y, Ukimura O, Yoneda K, Mizutani Y, Miki T. Bladder capacity at the time of enuresis. Urology 2003;61(5):1016.
Yeung CK, Chiu HN, Sit FK. Bladder dysfunction in children with refractory monosymptomatic primary nocturnal enuresis. J Urol 1999;162(3 Pt 2):1049.
Rittig S, Schaumburg HL, Siggaard C, Schmidt F, Djurhuus JC. The circadian defect in plasma vasopressin and urine output is related to desmopressin response and enuresis status in children with nocturnal enuresis. J Urol 2008;179(6):2389.
L. Dossche, A. Raes, P. Hoebeke, P. Circadian Rhythm of Glomerular Filtration and Solute Handling Related to Nocturnal Enuresis. J Urol 2016;195:162-167.
Wolfish NM, Pivik RT, Busby KA. Elevated sleep arousal thresholds in enuretic boys: clinical implications. Acta Paediatr 1997;86(4):381.
Hunsballe JM. Increased delta component in computerized sleep electroencephalographic analysis suggests abnormally deep sleep in primary monosymptomatic nocturnal enuresis. Scand J Urol Nephrol 2000;34(5):294.
Bader G, Nevéus T, Kruse S, Sillén U. Sleep of primary enuretic children and controls. Sleep 2002;25(5):579.
Bakwin H. The genetics of enuresis. In: Bladder control and enuresis. Kolvin RM, Meadows SR, editors. London: Medical Books Ltd, 1973;73.
Longstaffe S, Moffatt ME, Whalen JC. Behavioral and selfconcept changes after six months of enuresis treatment: a randomized, controlled trial. Pediatrics 2000;105(4 Pt 2):935.
Ullom-Minnich MR. Diagnosis and management of nocturnal enuresis. Am Fam Physician 1996;54(7):2259.
Vande Walle J, Rittig S, Bauer S, Eggert P, Marschall-Kehrel D, Tekgul S, American Academy of Pediatrics, European Society for Paediatric Urology, European Society for Paediatric Nephrology, International Children’s Continence Society. Practical consensus guidelines for the management of enuresis. Eur J Pediatr 2012;171(6):971-83.
Kovacevic L, Wolfe-Christensen C, Mirkovic J, Yih J, Lakshmanan Y. Renal bladder ultrasound evaluation in monosymptomatic primary nocturnal enuresis: is it really necessary?. Pediatr Nephrol 2014;29(7):1189-94.
Hodges SJ, Anthony EY. Occult megarectum--a commonly unrecognized cause of enuresis. Urology 2012;79(2):421.
Pippi Salle JL, Capolicchio G, Houle AM, Vernet O, Jednak R, O'Gorman AM, Montes JL, Farmer JP. Magnetic resonance imaging in children with voiding dysfunction: is it indicated?. J Urol 1998;160(3 Pt 2):1080.
Kiddo D. Nocturnal enuresis. BMJ Clin Evid. 2007;2007. pii:0305.
Jalkut MW, Lerman SE, Churchill BM. Enuresis. Pediatr Clin North Am 2001;48(6):1461.
Kjolseth D, Knudsen LM, Madsen B, Norgaard JP, Djurhuus JC. Urodynamic biofeedback training for children with bladdersphincter dyscoordination during voiding. Neurourol Urodyn 1993;12:211e21.
Kwak KW, Lee YS, Park KH, Baek M. Efficacy of desmopressin and enuresis alarm as first and second line treatment for primary monosymptomatic nocturnal enuresis: prospective randomized crossover study. J Urol 2010;184(6):2521.
Wille S. Comparison of desmopressin and enuresis alarm for nocturnal enuresis. Arch Dis Child 1986;61(1):30.
Glazener CM, Evans J. Desmopressin for nocturnal enuresis in children. Cochrane Database Syst Rev 2002;(3):CD002112.
U.S. Food and Drug Administration, 2007 Safety Alerts for Human Medical Products: Desmopressin Acetate (marketed as DDAVP Nasal Spray, DDAVP Rhinal Tube, DDAVP, DDVP, Minirin, and Stimate Nasal Spray). [En línea]. Dirección URL: . (Consulta: 10 de septiembre 2016).
32. Farida E, Sally Z, Marian K. Assessment of the efficacy of desmopressin in treatment of Primary Monosymptomatic Nocturnal Enuresis in Egyptian children. Egypt J Med Hum Gen. 2015;16:257-262.
33. Farzaneh S, Sepideh S, and Maryam T. Primary monosymptomatic nocturnal enuresis: monotherapy vs combination therapy. Urology 2016;93:170-174.
34. Aaron B, Jacqueline P, Pamela E. Evaluating use of higher dose oxybutynin in combination with desmopressin for refractory nocturnal enuresis. J Pediatr Urol 2016;12:220. e1-220.e6
35. Austin PF, Ferguson G, Yan Y, Campigotto MJ, Royer ME, Coplen DE. Combination therapy with desmopressin and an anticholinergic medication for nonresponders to desmopressin for monosymptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial. Pediatrics 2008;122(5):1027.
Konstantinos K, Søren R, Wendy F. Effect of Indomethacin on Desmopressin Resistant Nocturnal Polyuria and Nocturnal Enuresis. J Urol 2012;188:1915-1923.
Deshpande AV, Caldwell PH, Sureshkumar P. Drugs for nocturnal enuresis in children (other than desmopressin and tricyclics). Cochrane Database Syst Rev 2012;12:CD002238.
Caldwell PH, Sureshkumar P, Wong WC. Tricyclic and related drugs for nocturnal enuresis in children. Cochrane Database Syst Rev 2016;(1):CD002117.
Schmitt BD. Nocturnal enuresis. Pediatr Rev 1997;18(6):183.
Gepertz S, Nevéus T. Imipramine for therapy resistant enuresis: a retrospective evaluation. J Urol 2004;171(6 Pt 2):2607.